Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zora Mělková"'
Publikováno v:
Viruses, Vol 13, Iss 10, p 1986 (2021)
Vaccinia virus (VACV) is an enveloped DNA virus from the Orthopoxvirus family, various strains of which were used in the successful eradication campaign against smallpox. Both original and newer VACV-based replicating vaccines reveal a risk of seriou
Externí odkaz:
https://doaj.org/article/2d2d3ad0d00e4e25a44872f292c3763d
Autor:
Michaela Madlenakova, Prakash Shankaran, Vera Hajkova, David Jilich, Ladislav Machala, Pavel Martasek, Zora Melkova
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss , Pp 1- (2017)
Externí odkaz:
https://doaj.org/article/a7ccd4fb4dec404491c6a8d915034d6a
P1 Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro latency models
Autor:
Pawel Bonczkowski, Marie-Angélique De Scheerder, Eva Malatinkova, Alexandra Borch, Zora Melkova, Renate Koenig, Ward De Spiegelaere, Linos Vandekerckhove
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 4- (2016)
Externí odkaz:
https://doaj.org/article/2541de63fff8418eb646ee65303a0e75
Autor:
Albert Font-Haro, Vaclav Janovec, Tomas Hofman, Ladislav Machala, David Jilich, Zora Melkova, Jan Weber, Katerina Trejbalova, Ivan Hirsch
Publikováno v:
Viruses, Vol 10, Iss 4, p 154 (2018)
Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes of HIV-1-infection. The mechanism of dysfunction of pDCs is unclear. Here, we studied the development of phenotype of pDCs in a cohor
Externí odkaz:
https://doaj.org/article/83b2bf258ec547d8a04cc23f141c3ef8
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114374 (2014)
Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replicating Modified vaccinia virus Ankara (MVA) has bee
Externí odkaz:
https://doaj.org/article/95cf1131874d4f02b079df8ec3709b31
Autor:
Kateřina Veselá, Zora Mělková, Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Petr Dytrych, Alla Sinica, Oleksandra Vozniuk, Pavel Martásek, Milan Jakubek
Publikováno v:
Separations, Vol 10, Iss 2, p 73 (2023)
SARS-CoV-2 is a serious viral pathogen, and agents that inhibit its replication are in high demand. In the present work, we prepared two novel tryptanthrin derivates bearing a thiosemicarbazone moiety as potential antiviral agents. Both compounds dis
Externí odkaz:
https://doaj.org/article/256d5da4fbda42b8a4f4f26de373589e
Publikováno v:
Cytometry Part A. :110-116
Background Determination of mitochondrial membrane potential (ΔΨm) is widely used to characterize cellular metabolism, viability, and apoptosis. Changes of ΔΨm induced by inhibitors of oxidative phosphorylation characterize respective contributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d249d68c4185c05bdc50fa441615f6d7
https://doi.org/10.1002/cyto.a.10031
https://doi.org/10.1002/cyto.a.10031
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Vaccinia virus (VV) infects a broad range of host cells, and while it usually causes their lysis (i.e. necrosis), the nature of the cell-death phenomenon is not well understood. In this study, we show that VV induces apoptosis of cells of the murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d380e9badc2e17323d02bf0b24ecb8e0
https://doi.org/10.1099/0022-1317-83-11-2821
https://doi.org/10.1099/0022-1317-83-11-2821
Autor:
Mariano Esteban, Zora Mělková
Publikováno v:
Virology. 198:731-735
Interferon-γ inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-γ inhibits the growth of vaccinia virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e9fb410e7effd0adb83cc9a5dc8d66
https://doi.org/10.1006/viro.1994.1087
https://doi.org/10.1006/viro.1994.1087
Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme
Publikováno v:
Virology. 243(2)
Induction of apoptosis in mammalian cells by double-stranded (ds) RNA-dependent enzymes, protein kinase (PKR), and 2-5A-synthetase/RNase L (referred to as the 2-5A system) might be a mechanism mediating anticellular and antiviral actions of interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0bfd833eb0db92c0ebd68570f54dfb
https://pubmed.ncbi.nlm.nih.gov/9568039
https://pubmed.ncbi.nlm.nih.gov/9568039