Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Zora, Novakova"'
Autor:
Lucie Jedlickova, Kristyna Peterkova, Enoch Mensah Boateng, Lenka Ulrychova, Vojtech Vacek, Zsofia Kutil, Zhenze Jiang, Zora Novakova, Ivan Snajdr, Juan Kim, Anthony J. O’Donoghue, Cyril Barinka, Jan Dvorak
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-19 (2022)
Abstract Background Glutamate carboxypeptidase 2 (GCP2) belongs to the M28B metalloprotease subfamily encompassing a variety of zinc-dependent exopeptidases that can be found in many eukaryotes, including unicellular organisms. Limited information ex
Externí odkaz:
https://doaj.org/article/171091bf0d6344cabfbc2e43a9f14598
Autor:
Zora Novakova, Mirko Milosevic, Zsofia Kutil, Marketa Ondrakova, Barbora Havlinova, Petr Kasparek, Cristian Sandoval-Acuña, Zuzana Korandova, Jaroslav Truksa, Marek Vrbacky, Jakub Rohlena, Cyril Barinka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the decreased activity of protoporphyrinogen oxidase IX (PPO; E.C.1.3.3.4), the enzyme c
Externí odkaz:
https://doaj.org/article/c8c3edc54eb849c18d405c9c691a81f8
Autor:
Zora Novakova, Daria Khuntsaria, Marketa Gresova, Jana Mikesova, Barbora Havlinova, Shivam Shukla, Lucie Kolarova, Katerina Vesela, Pavel Martasek, Cyril Barinka
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Human protoporphyrinogen oxidase IX (hPPO) is an oxygen-dependent enzyme catalyzing the penultimate step in the heme biosynthesis pathway. Mutations in the enzyme are linked to variegate porphyria, an autosomal dominant metabolic disease. Here we inv
Externí odkaz:
https://doaj.org/article/15ba44b9ea1d49f19a7c6fcf821c348b
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61bb7d243008e9d6f4b09ab8d78dbcdc
https://doi.org/10.1007/978-1-0716-2788-4_29
https://doi.org/10.1007/978-1-0716-2788-4_29
Autor:
Jana, Mikesova, Marketa, Ondrakova, Iva, Jelinkova, Jakub, Ptacek, Zora, Novakova, Cyril, Barinka
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2589
During the preclinical development of small molecule inhibitors, compounds or compound libraries are typically first screened using purified target enzymes in vitro to select candidates with high potency. In the later stages of the development, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f0ab9b11add14a5ce5f454f61ce70a8
https://pubmed.ncbi.nlm.nih.gov/36255642
https://pubmed.ncbi.nlm.nih.gov/36255642
Autor:
Shivam Shukla, Jan Komarek, Zora Novakova, Jana Nedvedova, Kseniya Ustinova, Pavla Vankova, Alan Kadek, Charlotte Uetrecht, Haydyn Mertens, Cyril Barinka
Publikováno v:
The FEBS journal 290(3), 821-836 (2022). doi:10.1111/febs.16616
The FEBS journal 290(3), 821 - 836 (2022). doi:10.1111/febs.16616
Human histone deacetylase 6 (HDAC6) is a structurally unique, multido-main protein implicated in a variety of physiological processes includingcytoskeletal remodelling and the mai
Human histone deacetylase 6 (HDAC6) is a structurally unique, multido-main protein implicated in a variety of physiological processes includingcytoskeletal remodelling and the mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d025c08504885036741e0dc51197cbd
https://pubmed.ncbi.nlm.nih.gov/36062318
https://pubmed.ncbi.nlm.nih.gov/36062318
Autor:
null Shivam Shukla, null Jan Komarek, null Zora Novakova, null Jana Nedvedova, null Kseniya Ustinova, null Pavla Vankova, null Alan Kadek, null Charlotte Uetrecht, null Haydyn Mertens, null Cyril Barinka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c1a86405805f75e56875c21b60a14c
https://doi.org/10.1111/febs.16616/v3/response1
https://doi.org/10.1111/febs.16616/v3/response1
Autor:
Frederik L. Giesel, Yvonne Remde, Max Geerlings, Matthias Eder, Martina Benešová, Cyril Barinka, Klaus Kopka, Lucia Motlova, Ulrike Bauder-Wüst, Mareike Roscher, Martin Schäfer, Jens Cardinale, Zora Novakova
Publikováno v:
Journal of Medicinal Chemistry. 63:10897-10907
In recent years, a number of drugs targeting the prostate-specific membrane antigen (PSMA) have become important tools in the diagnosis and treatment of prostate cancer. In the present work, we report on the synthesis and preclinical evaluation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f75355b95f30d32c460f1639d2a8255c
https://doi.org/10.1021/acs.jmedchem.9b01479
https://doi.org/10.1021/acs.jmedchem.9b01479
Autor:
Liming Qiu, Jakub Ptacek, Petr Kolenko, Lucia Motlova, Shi-Jie Chen, Paloma H. Giangrande, Sven Kruspe, Dong Zhang, Barbora Havlinova, Petra Baranova, Shambhavi Shubham, Zora Novakova, Xiaoqin Zou, Cyril Barinka
Publikováno v:
Nucleic Acids Research
Prostate-specific membrane antigen (PSMA) is a well-characterized tumor marker associated with prostate cancer and neovasculature of most solid tumors. PSMA-specific ligands are thus being developed to deliver imaging or therapeutic agents to cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3508f7a2aee1067e91a5f2403f17bd53
http://europepmc.org/articles/PMC7641732
http://europepmc.org/articles/PMC7641732
Autor:
Zora, Novakova, Jana, Mikesova, Marketa, Ondrakova, Zsofia, Kutil, Katerina, Vesela, Pavel, Martasek, Cyril, Barinka
Publikováno v:
Biochemical and biophysical research communications. 588
Variegate porphyria is caused by mutations in the protoporphyrinogen oxidase IX (PPOX, EC 1.3.3.4) gene, resulting in reduced overall enzymatic activity of PPOX in human tissues. Recently, we have identified the His333Arg mutation in the PPOX protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0396feaca901057762f9e7337ab66224
https://pubmed.ncbi.nlm.nih.gov/34968794
https://pubmed.ncbi.nlm.nih.gov/34968794