Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Zongzhi Z Liu"'
Autor:
Sally J. Adua, Anna Arnal-Estapé, Minghui Zhao, Bowen Qi, Zongzhi Z. Liu, Carolyn Kravitz, Heather Hulme, Nicole Strittmatter, Francesc López-Giráldez, Sampada Chande, Alexandra E. Albert, Mary-Ann Melnick, Bomiao Hu, Katerina Politi, Veronica Chiang, Nicola Colclough, Richard J. A. Goodwin, Darren Cross, Paul Smith, Don X. Nguyen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
While EGFR-targeted therapies have clinical benefit, drug-resistant brain metastases present a major obstacle. Here, the authors identify a genetic signature in brain metastatic lesions associated with osimertinib resistance and find RhoA to have an
Externí odkaz:
https://doaj.org/article/3190ed6c2b6648c6bd0e559653995e8f
Autor:
Weijia Cai, Liya Su, Lili Liao, Zongzhi Z. Liu, Lauren Langbein, Essel Dulaimi, Joseph R. Testa, Robert G. Uzzo, Zhijiu Zhong, Wei Jiang, Qin Yan, Qing Zhang, Haifeng Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal domain acetylation on lysine 382 through its bromodomain 4 and that muta
Externí odkaz:
https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c
Autor:
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin
Externí odkaz:
https://doaj.org/article/39034a1a1b414222967219825619062a
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen C Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/a50046e84ed442a683b9fc60b5d5c454
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Acquired resistance to HER2-targeted therapies occurs frequently in HER2+ breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is reversible, as resistant cells regained sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742603bf6c8428c05637f9e53de3cb10
https://doi.org/10.1158/0008-5472.c.6512016.v1
https://doi.org/10.1158/0008-5472.c.6512016.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Table 2: BT-TR1 versus BT474 RNA sequencing normalized gene expression Supplementary Table 3: BT-TR2 versus BT474 RNA sequencing normalized gene expression Supplementary Table 4: BT-TPR1 versus BT474 RNA sequencing normalized gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325411ac839ced214980806e39f4c086
https://doi.org/10.1158/0008-5472.22425378.v1
https://doi.org/10.1158/0008-5472.22425378.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Figure 1: Generation and characterization of resistant cell pools. Supplementary Figure 2: Copy number assessment of receptor tyrosine kinases in resistant cell pools. Supplementary Figure 3: Trastuzumab resistance is reversible. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82650a9bb458b36bd2c75909d032d29d
https://doi.org/10.1158/0008-5472.22425381
https://doi.org/10.1158/0008-5472.22425381
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 7 (2018)
Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains
Externí odkaz:
https://doaj.org/article/469424e6a2dc4921b7e109a9d371cd8e
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Autor:
Meiling Zhang, Zongzhi Z. Liu, Keisuke Aoshima, Wesley L. Cai, Hongyin Sun, Tianrui Xu, Yangyi Zhang, Yongyan An, Jocelyn F. Chen, Lok Hei Chan, Asako Aoshima, Sabine M. Lang, Zhenwei Tang, Xuanlin Che, Yao Li, Sara J. Rutter, Veerle Bossuyt, Xiang Chen, Jon S. Morrow, Lajos Pusztai, David L. Rimm, Mingzhu Yin, Qin Yan
Publikováno v:
Sci Transl Med
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b969c03a480097e32208712f707c84f
https://doi.org/10.1126/scitranslmed.abf5473
https://doi.org/10.1126/scitranslmed.abf5473