Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zongyun Huang"'
Publikováno v:
Journal of Drug Delivery Science and Technology. 80:104160
Autor:
Zongyun Huang, William P. Fish
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 172
This paper describes the development of simple and user-friendly HPLC methods that can quantitate the amount of small interfering RNA (siRNA) in lipid-based nanoparticle (LNP) formulations. The methods have been used as alternative chromatographic ap
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 151
This paper describes the development of a simple reversed-phase HPLC method that can quantitate trace amounts of a polymeric degradants (BMT-041910) in asunaprevir drug substance and formulated drug product with quantitation limits of ∼0.05% w/w. T
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
Establishing and maintaining the correct formulation composition is essential for ensuring the stability of biopharmaceutical drug products. A barrier to the routine assessment of excipient concentration is the lack of convenient and robust methods f
Publikováno v:
International journal of pharmaceutics. 535(1-2)
In the pharmaceutical industry, in vitro dissolution testing ofsolid oral dosage forms is a very important tool for drug development and quality control. However, ion-pairing interaction between the ionic drugand surfactants in dissolution medium oft
From Bench to Humans: Formulation Development of a Poorly Water Soluble Drug to Mitigate Food Effect
Autor:
Neil Mathias, Dilbir S. Bindra, Zongyun Huang, Preetanshu Pandey, Brian Yan, Timothy Eley, Robert K. Perrone, Chandra Vemavarapu, John R. Crison, Rhye Hamey
Publikováno v:
AAPS PharmSciTech. 15:407-416
This study presents a formulation approach that was shown to mitigate the dramatic food effect observed for a BCS Class II drug. In vitro (dissolution), in vivo (dog), and in silico (GastroPlus®) models were developed to understand the food effect a
Publikováno v:
Journal of Pharmaceutical Innovation. 6:115-123
The compound studied, an antagonist of corticotropin-releasing factor (CRF) receptor 1, was under development for the treatment of major depressive disorder and generalized anxiety disorder. To control the quality of intermediate compounds in the syn
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 102
A simple, sensitive and robust method using HILIC-ESI-MS has been developed for the determination of methane sulfonic acid (MSA) at low ppm level in order to verify the effectiveness of controlling the formation of genotoxic sulfonate esters in the d
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 50(5)
A simple generic approach was investigated for the determination of inorganic pharmaceutical counterions in drug substances using conventional high performance liquid chromatographic (HPLC) instruments. An intuitive approach combined Corona charged a