Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zongyu Cai"'
Autor:
Ke Zhang, Qimuge Wuri, Zongyu Cai, Xueli Qu, Shiqi Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Xianghui Yu, Wei Kong, Haihong Zhang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1880 (2024)
With the advent of cancer immunotherapy, there is a growing interest in vaccine development as a means to activate the cellular immune system against cancer. Despite the promise of DNA vaccines in this regard, their effectiveness is hindered by poor
Externí odkaz:
https://doaj.org/article/d34beaf399b1410eae6c77d68abb44b9
Autor:
Qiang Ren, Ya Chen, Zongtao Zhou, Zongyu Cai, Shixuan Jiao, Wanqiu Huang, Bin Wang, Siliang Chen, Wenxin Wang, Zhijun Cao, Zhongcheng Yang, Liming Deng, Lijun Hu, Luyong Zhang, Zheng Li
Publikováno v:
Journal of Medicinal Chemistry. 66:6082-6104
Autor:
Ling Dong, Mengfan Feng, Yaru Qiao, Chenlu Liu, Yi Zhou, Shanshan Xing, Ke Zhang, Zongyu Cai, Hui Wu, Jiaxin Wu, Xianghui Yu, Haihong Zhang, Wei Kong
Publikováno v:
Human Gene Therapy. 33:757-764
The safety, biodistribution, and pharmacokinetics of any new therapeutic tumor DNA vaccine must be evaluated in preclinical studies. We previously developed the DNA vaccine (CpDV-IL2-sPD1/MUC1 and survivin), which showed excellent antitumor effects i
Autor:
Bin Wang, Zongyu Cai, Huixin Yao, Shixuan Jiao, Siliang Chen, Zhongcheng Yang, Wanqiu Huang, Qiang Ren, Zhijun Cao, Ya Chen, Luyong Zhang, Zheng Li
Publikováno v:
European journal of medicinal chemistry. 245(Pt 1)
Type 2 diabetes mellitus (T2DM) is a lifelong disease that requires long-term medication to control glucose levels, and thereby long-acting drug has been clinically needed for improving medical adherence. The free fatty acid receptor 1 (FFA1) was con
Autor:
Bin Wang, Zongyu Cai, Siliang Chen, Ya Chen, Shixuan Jiao, Qiang Ren, Xuekun Wang, Xinqian Geng, Zheng Li, Guangji Wang
Publikováno v:
ChemistrySelect. 7
Autor:
Zongyu Cai, Bin Wang, Zongtao Zhou, Xin Zhao, Lijun Hu, Qiang Ren, Liming Deng, Zheng Li, Guangji Wang
Publikováno v:
Chemical biologydrug designREFERENCES. 99(3)
Acetaminophen (APAP) overdose is a leading cause of acute hepatic failure and liver transplantation, while the existing treatments are poorly effective. Therefore, it is necessary to develop effective therapeutic drugs for APAP-induced hepatotoxicity
Autor:
Zongtao Zhou, Qiang Ren, Shixuan Jiao, Zongyu Cai, Xinqian Geng, Liming Deng, Bin Wang, Lijun Hu, Luyong Zhang, Ying Yang, Zheng Li
Publikováno v:
European Journal of Medicinal Chemistry. 229:114061
Non-alcoholic fatty liver disease (NAFLD) has become the most common hepatic disease, while no drug was approved until now. The previous study reported that the quadruple FFA1/PPAR-α/γ/δ agonist RLA8 provided better efficacy than obeticholic acid
Autor:
Zongtao Zhou, Zongyu Cai, Congzi Zhang, Benhui Yang, Lianru Chen, Yepu He, Luyong Zhang, Zheng Li
Publikováno v:
Bioorganic & Medicinal Chemistry. 56:116615
The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their respective roles in promoting insulin secretion a
Publikováno v:
Bioorganic chemistry. 99
Many peroxisome proliferator-activated receptors (PPARs) agonists have been developed for the treatment of metabolic disorders, while several PPARs agonists were discontinued in clinical trials because of PPARγ related side effects. In order to incr
Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome
Publikováno v:
European Journal of Medicinal Chemistry. 225:113807
The peroxisome proliferator-activated receptors (PPARs) exert vital function in the regulation of energy metabolism, which were considered as promising targets of metabolic syndrome. Until now, PPARδ/γ dual agonist is rarely reported, and thereby t