Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Zongyang Lu"'
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 84, Iss 6, Pp 1-12 (2024)
Abstract The neutrinophilic two Higgs doublet model is one of the simplest models to explain the origin of tiny Dirac neutrino masses. This model introduces a new Higgs doublet with eV scale VEV to naturally generate the tiny neutrino masses. Dependi
Externí odkaz:
https://doaj.org/article/b0256174d73442aa80f6c0b15526b656
Autor:
Hongyu Chen, Xingchen Liu, Lanxin Li, Qingtong Tan, Shiyan Li, Li Li, Chunyang Li, Jiqiang Fu, Yong Lu, Yan Wang, Yidi Sun, Zhen-Ge Luo, Zongyang Lu, Qiang Sun, Zhen Liu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract The efficiency of homology-directed repair (HDR) plays a crucial role in the development of animal models and gene therapy. We demonstrate that microhomology-mediated end-joining (MMEJ) constitutes a substantial proportion of DNA repair duri
Externí odkaz:
https://doaj.org/article/d2b7388e9959421b9e75db3577db4141
Autor:
Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang, Xiaoqun Wang, Jiang Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding dive
Externí odkaz:
https://doaj.org/article/ace5978364b447ad9fd5c4e517e51b91
Autor:
Zongyang Lu, Jie Li, Yong Lu, Ling Li, Wei Wang, Chenchen Zhang, Libing Xu, Yanhong Nie, Changshan Gao, Xinyan Bian, Zhen Liu, Guang-Zhong Wang, Qiang Sun
Publikováno v:
The Innovation, Vol 4, Iss 3, Pp 100436- (2023)
Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notab
Externí odkaz:
https://doaj.org/article/66c0a6668ca14d2fbdd7b3b529541d89
Autor:
Jianxiang Lin, Xingchen Liu, Zongyang Lu, Shisheng Huang, Susu Wu, Wenxia Yu, Yao Liu, Xiaoguo Zheng, Xingxu Huang, Qiang Sun, Yunbo Qiao, Zhen Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 494-501 (2021)
Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here,
Externí odkaz:
https://doaj.org/article/6660187d2dc3426d8bc611ea355af90e
Autor:
Guanglei Li, Xinyi Liu, Shisheng Huang, Yanting Zeng, Guang Yang, Zongyang Lu, Yu Zhang, Xu Ma, Lisheng Wang, Xingxu Huang, Jianqiao Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 289-296 (2019)
Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos. However, the precisio
Externí odkaz:
https://doaj.org/article/fea2489a8be046999f9f4a55792b46f4
Autor:
Shisheng Huang, Zhaodi Liao, Xiangyang Li, Zhen Liu, Guanglei Li, Jianan Li, Zongyang Lu, Yu Zhang, Xiajun Li, Xu Ma, Qiang Sun, Xingxu Huang
Publikováno v:
iScience, Vol 15, Iss , Pp 640-648 (2019)
Summary: RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases. Recently developed base editors (BEs) offer a new strategy
Externí odkaz:
https://doaj.org/article/316adc0692114e85b281930f7d0d9de8
Autor:
Kun Jia, Zongyang Lu, Fei Zhou, Zhiqi Xiong, Rui Zhang, Zhiwei Liu, Yu’e Ma, Lei He, Cong Li, Zhen Zhu, Dejing Pan, Zhengxing Lian
Publikováno v:
Protein & Cell, Vol 10, Iss 11, Pp 832-839 (2019)
Externí odkaz:
https://doaj.org/article/8d0f44ef5c3d4aca85d9b5efad5c22cf
Autor:
Xiao Wang, Chengfeng Ding, Wenxia Yu, Ying Wang, Siting He, Bei Yang, Yi-Chun Xiong, Jia Wei, Jifang Li, Jiayi Liang, Zongyang Lu, Wei Zhu, Jing Wu, Zhi Zhou, Xingxu Huang, Zhen Liu, Li Yang, Jia Chen
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The advent of base editors (BEs) holds great potential for correcting pathogenic-related point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs lead to DNA double-strand breaks, which can trigger unwanted DNA d
Externí odkaz:
https://doaj.org/article/b2929ee16b7d43649d54cf47e28a6ed2
Autor:
Zongyang Lu, Xingxu Huang
Publikováno v:
Cell Stress, Vol 2, Iss 10, Pp 242-245 (2018)
Myriads of genetic mutations, including base substitutions, deletions, and insertions as well as chromosome structural variations, have been detected in many human diseases. Although current combination of genomics and bioinformatics has contributed
Externí odkaz:
https://doaj.org/article/e50c545600fd4d80b07e590fab2687ed