Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zonglong Hu"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Histone deacetylase (HDAC) is a kind of protease that modifies histone to regulate gene expression, and is usually abnormally activated in tumors. The approved pan-HDAC inhibitors have demonstrated clinical benefits for patients in some hema
Externí odkaz:
https://doaj.org/article/e398fc592c2e4529b43a29d207d4217d
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 350-357 (2019)
Externí odkaz:
https://doaj.org/article/e4e5a17369974103803649c08b9e9b0b
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 1, Pp 350-357 (2019)
ACS Omega, Vol 5, Iss 1, Pp 350-357 (2019)
7-Ethyl-10-hydroxycamptothecin (SN38) and vorinostat (SAHA) are quite promising combination therapy agents applied to the clinical treatment of cancer. In this study, we designed and synthesized a series of novel SN38-SAHA co-prodrugs, which were con
Autor:
Qiumeng Zhang1 (AUTHOR) qiumeng-zhang@foxmail.com, Zonglong Hu2 (AUTHOR) zlhu@jding.dhs.org, Qianqian Shen2 (AUTHOR) shenqianqian@simm.ac.cn, Yi Chen2 (AUTHOR) ychen@simm.ac.cn, Wei Lu1 (AUTHOR) wlu@chem.ecnu.edu.cn
Publikováno v:
Molecules. May2017, Vol. 22 Issue 5, p788. 16p. 4 Diagrams, 3 Charts.
Publikováno v:
Molecules; Volume 22; Issue 5; Pages: 788
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Thieno[3,2-d]pyrimidine as an effective pharmacophore has been extensively studied. However, its 2,6-substituted derivatives are rarely reported. In the present study, eighteen 2,6-substituted thieno[3,2-d]pyrimidine derivatives containing electrophi