Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zonghua Luo"'
Publikováno v:
iRADIOLOGY, Vol 2, Iss 1, Pp 35-65 (2024)
Abstract Colony‐stimulating factor 1 receptor (CSF1R) is highly expressed in mononuclear phagocytes and in the central nervous system. It has emerged as a promising target for tumor therapy and neuroinflammation imaging. Although therapeutic agents
Externí odkaz:
https://doaj.org/article/e6dd4cd2ca7e436790bc528372221502
Publikováno v:
RSC Med Chem
A series of twenty-nine new quinazoline-2,4-dione compounds were synthesized and their IC(50) values for binding toward sphingosine-1-phosphate receptor 2 (S1PR2) were determined using a [(32)P]S1P binding assay. Seven compounds 2a, 2g, 2h, 2i, 2j, 2
Publikováno v:
Nucl Med Biol
INTRODUCTION: Sphingosine-1-phosphate receptor 2 (S1PR2) activation exerts a critical role in biological abnormalities and diseases. A suitable radiotracer will advance our understanding of S1PR2 pathophysiology of diseases. The objective of this stu
Autor:
Yun Zhou, Kooresh I. Shoghi, Jiwei Gu, Tammie L.S. Benzinger, Zonghua Luo, Robert J. Gropler, Hao Jiang, Hui Liu, Zhude Tu, Sumit Joshi
Publikováno v:
Molecular Imaging and Biology. 22:1362-1369
The sphingosine-1-phosphate receptor 1 (S1PR1) is an important biomarker for imaging inflammation in the central nervous system (CNS). Herein, we report our recent evaluation of four 18F-labeled S1PR1 tracers (18F-TZ43113, 18F-TZ35104, 18F-TZ4877, an
Autor:
Zhude Tu, Robert C. Dennett, Tammie L.S. Benzinger, Jiwei Gu, Joel S. Perlmutter, Delphine L. Chen, Gregory G. Gaehle, Zonghua Luo
Publikováno v:
Applied Radiation and Isotopes. 152:30-36
Automated synthesis of a radiopharmaceutical 3-((2-fluoro-4-(5-(2′-methyl-2-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)-1,2,4-oxadiazol-3-yl)benzyl) (methyl-11C)amino)propanoic acid ([11C]CS1P1) for PET imaging sphingosine-1 phosphate receptor 1 (S1P
Publikováno v:
Bioorg Med Chem
Twenty eight new aryloxybenzene analogues were synthesized and their in vitro binding potencies toward S1PR2 were determined using a [32P]S1P competitive binding assay. Out of these new analogues, three compounds, 28c (IC50 = 29.9 ± 3.9 nM), 28e (IC
Autor:
Stephen Moerlein, Zonghua Luo, Christopher Bognar, Greg Gaehle, Reiko Oyama, Gwendolyn Randolph, Michael Nickels
Publikováno v:
Nuclear Medicine and Biology. :S144
Autor:
Hui, Liu, Zonghua, Luo, Jiwei, Gu, Hao, Jiang, Sumit, Joshi, Kooresh I, Shoghi, Yun, Zhou, Robert J, Gropler, Tammie L S, Benzinger, Zhude, Tu
Publikováno v:
Mol Imaging Biol
PURPOSE: The sphingosine-1-phosphate receptor 1 (S1PR1) is an important biomarker for imaging inflammation in the central nervous system (CNS). Herein we report our recent evaluation of four (18)F-labeled S1PR1 tracers ((18)F-TZ43113, (18)F-TZ35104,
Autor:
Zonghua Luo, Jiwei Gu, Kota Kaneshige, Stanley M. Parsons, Hongjun Jin, Yanbo Yu, Joel S. Perlmutter, Hui Liu, Zhude Tu
Publikováno v:
ChemMedChem. 13:1978-1987
Sixteen new sulfur-containing compounds targeting the vesicular acetylcholine transporter (VAChT) were synthesized and assessed for in vitro binding affinities. Enantiomers (-)-(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-(methyl
Publikováno v:
Journal of Neuroimmunology. 318:29-35
Cholinergic dysfunction in the central nervous system is an important characteristic of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). By using a rat EAE model, upregulation of vesicular acetylcholine transporter (VAChT) leve