Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zong-Heng Wang"'
Publikováno v:
eLife, Vol 8 (2019)
Oogenesis features an enormous increase in mitochondrial mass and mtDNA copy number, which are required to furnish mature eggs with an adequate supply of mitochondria and to curb the transmission of deleterious mtDNA variants. Quiescent in dividing g
Externí odkaz:
https://doaj.org/article/65506475181749d0a359417592b01631
Publikováno v:
Biology Open, Vol 4, Iss 5, Pp 636-648 (2015)
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover a new role for Clu in the delivery of integrin subunits in muscle tissue. In clu mutants, αPS2 integrin, b
Externí odkaz:
https://doaj.org/article/9822a097ea7e483c842b373d558fc3c3
Autor:
Yi Liu, Zhe Chen, Zong-Heng Wang, Katherine M. Delaney, Juanjie Tang, Mehdi Pirooznia, Duck-Yeon Lee, Ilker Tunc, Yuesheng Li, Hong Xu
Publikováno v:
Nature Cell Biology. 24:757-765
Mitochondrial DNA (mtDNA) replication and transcription are of paramount importance to cellular energy metabolism. Mitochondrial RNA polymerase is thought to be the primase for mtDNA replication. However, it is unclear how this enzyme, which normally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd5a191b16132f5bdceede67bbe3246
https://doi.org/10.1038/s41556-022-00887-y
https://doi.org/10.1038/s41556-022-00887-y
In multicellular lives, differentiation of many types of stem and progenitor cells is often accompanied by a metabolic transition from glycolysis to mitochondrial oxidative phosphorylation. The mechanisms driving this metabolic transition in vivo are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abebe8ef3183c6247f9106a2b3ce88f8
https://doi.org/10.21203/rs.3.rs-1598552/v1
https://doi.org/10.21203/rs.3.rs-1598552/v1
Autor:
Yi Liu, Zhe Chen, Zong-Heng Wang, Katherine Delaney, Juanjie Tang, Mehdi Pirooznia, Duck-Yeon Lee, Yuesheng Li, Hong Xu
Mitochondrial DNA (mtDNA) replication and transcription are of paramount importance to cellular energy metabolism. Mitochondrial RNA polymerase (POLRMT) is thought to be the primase for mtDNA replication. However, it is unclear how POLRMT, which norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9aee9fa03c0cac8aa571c9d4b9776e5
https://doi.org/10.1101/2021.03.12.435139
https://doi.org/10.1101/2021.03.12.435139
Autor:
Dillon J. Chung, Zhe Chen, Christopher K. E. Bleck, Grey P. Madison, Guofeng Zhang, Christian A. Combs, Eric Lindberg, Robert S. Balaban, Zong-Heng Wang, Hong Xu
Publikováno v:
The Journal of Cell Biology
Chen et al. demonstrate that a series of developmentally orchestrated mitochondrial processes in the Drosophila early germarium, including mtDNA segregation, transcription, and replication, allow the functional manifestation of individual genomes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561c93ab8dd322fc841b0c99f632d7ed
https://doi.org/10.1083/jcb.201905160
https://doi.org/10.1083/jcb.201905160
Publikováno v:
Hum Mol Genet
PINK1/Parkin-mediated mitochondrial quality control (MQC) requires valosin-containing protein (VCP)-dependent Mitofusin/Marf degradation to prevent damaged organelles from fusing with the healthy mitochondrial pool, facilitating mitochondrial clearan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25db1ad423677e66c586cd65dc068f5b
https://pubmed.ncbi.nlm.nih.gov/26931463
https://pubmed.ncbi.nlm.nih.gov/26931463
Autor:
Zhe Chen, Dillon J. Chung, Christian A. Combs, Robert S. Balaban, Zong-Heng Wang, Bleck Cke, Huichun Xu, Eric Lindberg, Grey P. Madison, Guofeng Zhang
Although mitochondrial DNA (mtDNA) is prone to mutation and not all conventional DNA repair systems operate in mitochondria, deleterious mutations are exceedingly rare. How the transmission of detrimental mtDNA mutations is restricted through the mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6f757d0dcf8a0649ac062fec4ad061
https://doi.org/10.1101/646638
https://doi.org/10.1101/646638
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Oogenesis features an enormous increase in mitochondrial mass and mtDNA copy number, which are required to furnish mature eggs with an adequate supply of mitochondria and to curb the transmission of deleterious mtDNA variants. Quiescent in dividing g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925e5db428e1df949878ef59158e1fba
https://doi.org/10.1101/642314
https://doi.org/10.1101/642314
Publikováno v:
Human Molecular Genetics. 25:1946-1964
PINK1/Parkin-mediated mitochondrial quality control (MQC) requires valosin-containing protein (VCP)-dependent Mitofusin/Marf degradation to prevent damaged organelles from fusing with the healthy mitochondrial pool, facilitating mitochondrial clearan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe93fc3d163619c7704200d0992aa23
https://doi.org/10.1093/hmg/ddw067
https://doi.org/10.1093/hmg/ddw067