Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Zong Ru Guo"'
Autor:
Zong-ru, Guo
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 52(1)
Precision medicine (PM) involves the application of "omics" analysis and system biology to analyze the cause of disease at the molecular level for targeted treatments of individual patient. Based on the targeted treatment PM is closely related to pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4717d5ccd25e97d80500bf31bfee152
https://pubmed.ncbi.nlm.nih.gov/29911773
https://pubmed.ncbi.nlm.nih.gov/29911773
Autor:
Zong-ru, Guo
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 51(8)
More attention has been paid to the pioneering drug innovation since the new millennium, while the creation space of fast-followed drugs is shrinking due to the serious risks observed in the clinical phases following marketing. Innovative drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23194917453e28519656dc5e34f039d0
https://pubmed.ncbi.nlm.nih.gov/29897709
https://pubmed.ncbi.nlm.nih.gov/29897709
Autor:
Zong-ru, Guo
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 51(3)
Drug innovation involves an individual molecular operation, and every new molecular entity features a hard-duplicated track of RD. The transformation from an active compound to a new medicine carries out almost in a chaotic system devoid of regularit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::999f6a227c7015663a9bd3070a9da719
https://pubmed.ncbi.nlm.nih.gov/29858888
https://pubmed.ncbi.nlm.nih.gov/29858888
Publikováno v:
Acta Pharmacologica Sinica. 27:506-512
Aim: Imrecoxib is a novel and moderately selective COX-2 inhibitor. The aim of the present in vitro investigation was to study the formation of the major metabolite 4'-carboxylic acid imrecoxib (M2) and identify the enzyme(s) involved in the reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f01d2d8b117c691596d5f2ec60df6a
https://doi.org/10.1111/j.1745-7254.2006.00312.x
https://doi.org/10.1111/j.1745-7254.2006.00312.x
Publikováno v:
Acta Pharmacologica Sinica. 27:372-380
Aim: To investigate the in vitro metabolism of imrecoxib in rat liver microsomes and to identify the cytochrome P450 (CYP) forms involved in its metabolism. Methods: Liver microsomes of Wistar rats were prepared using an ultracentrifuge. The in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0afe857265712e0d13aba101ba55b462
https://doi.org/10.1111/j.1745-7254.2006.00265.x
https://doi.org/10.1111/j.1745-7254.2006.00265.x
Autor:
Jin-ping Qiao, Zeper Abliz, Yan Chang, Zong-ru Guo, Pei-ling Hou, Liyan Zhao, Min Xia, Feng-ming Chu
Publikováno v:
Journal of Chromatography B. 805:93-99
6-Aminobutylphthalide (ABP) is a new drug candidate which is currently being developed for the treatment of cerebral ischemia. The pharmacokinetics and metabolism of ABP were studied using in situ microdialysis sampling in the brains of awake freely-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bafb5968a6ea8a9cf6a509984bbc0cd
https://doi.org/10.1016/j.jchromb.2004.02.017
https://doi.org/10.1016/j.jchromb.2004.02.017
Publikováno v:
Rapid Communications in Mass Spectrometry. 18:584-587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aa086a0700964b9fe88d0ea3b69cf1
https://doi.org/10.1002/rcm.1362
https://doi.org/10.1002/rcm.1362
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 49(6)
This study is to explore new lead compounds by inhibition of Pin1 for anticancer therapy using temperature sensitive mutants. As Pin1 is conserved from yeast to human, we established a high-throughput screening method for Pin1 inhibitors, which emplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cdf5a8664770abe390e6934c159c6e7
https://pubmed.ncbi.nlm.nih.gov/25212032
https://pubmed.ncbi.nlm.nih.gov/25212032
Autor:
Zong-Ru, Guo
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 48(12)
Pharmacological activity and druggability are two pivotal factors in drug innovation, which are respectively determined by the microscopic structure and macroscopic property of a molecule. Since structural optimization consists in a molecular operati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c64b596c27b37cfb2f5b7b40e0b8a0d
https://pubmed.ncbi.nlm.nih.gov/24689231
https://pubmed.ncbi.nlm.nih.gov/24689231
Autor:
Zong-Ru Guo, 郭宗儒
102
Research on bolt under eccentric load in the current literature related to a very limited number, strength analysis method is divided into elastic and elastic limit method, method is simple but is not the economy, and the analysis of nonline
Research on bolt under eccentric load in the current literature related to a very limited number, strength analysis method is divided into elastic and elastic limit method, method is simple but is not the economy, and the analysis of nonline
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/rb3v34
