Macrophage migration inhibitory factor as a diagnostic and predictive biomarker in sepsis: meta-analysis of clinical trials

Autor: Janos Toldi, David Nemeth, Peter Hegyi, Zsolt Molnar, Margit Solymar, Nelli Farkas, Hussain Alizadeh, Zoltan Rumbus, Eszter Pakai, Andras Garami

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract The hunt for useful sepsis biomarkers is ongoing. Macrophage migration inhibitory factor (MIF) was implicated as a biomarker in sepsis, but its diagnostic and prognostic value has remained unclear in human studies. Here, we aimed at clarifyi

Externí odkaz: https://doaj.org/article/2ced19890280486aa347af94b9db1a03

Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis.

Autor: Alexandra Csenkey, Gergo Jozsa, Noemi Gede, Eszter Pakai, Benedek Tinusz, Zoltan Rumbus, Anita Lukacs, Zoltan Gyongyi, Peter Hamar, Robert Sepp, Andrej A Romanovsky, Peter Hegyi, Peter Vajda, Andras Garami

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0223063 (2019)

In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious complications is debated. The present meta-analysis aimed at determining whether systemic antib

Externí odkaz: https://doaj.org/article/5540d1478bc348faa91b799122109a47

The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice

Autor: Eszter Pakai, Valeria Tekus, Csaba Zsiboras, Zoltan Rumbus, Emoke Olah, Patrik Keringer, Nora Khidhir, Robert Matics, Laszlo Deres, Katalin Ordog, Nikolett Szentes, Krisztina Pohoczky, Agnes Kemeny, Peter Hegyi, Erika Pinter, Andras Garami

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Neurokinin (NK) signaling is involved in various inflammatory processes. A common manifestation of systemic inflammation is fever, which is usually induced in animal models with the administration of bacterial lipopolysaccharide (LPS). A role for the

Externí odkaz: https://doaj.org/article/24fb3661dfb040a48e9cd7f553bf5166

Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice

Autor: János Garai, Patrik Keringer, Marcell Krekó, László Őrfi, Balázs Radnai, Peter B. Jakus, Zoltan Rumbus, Eszter Vámos, Viola Bagone Vantus, Dominika Kovacs, András Garami, Tamás Lóránd

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1356-1368 (2021)

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96256fb0e919d7c6d2708f0f50e6118
http://europepmc.org/articles/PMC8266241

Menthol can be safely applied to improve thermal perception during physical exercise: a meta-analysis of randomized controlled trials

Autor: Noémi Gede, Gábor Varga, Kasidid Ruksakiet, Nelli Farkas, András Garami, Margit Solymár, Zoltan Rumbus, Zsolt Lohinai, Patrik Keringer, Péter Hegyi

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

Menthol is often used as a cold-mimicking substance to allegedly enhance performance during physical activity, however menthol-induced activation of cold-defence responses during exercise can intensify heat accumulation in the body. This meta-analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a159e4356446e537c38710304206e03
http://link.springer.com/article/10.1038/s41598-020-70499-9