Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Zoltán Spolarics"'
Autor:
Balázs Csóka, Zoltán H Németh, Partha Mukhopadhyay, Zoltán Spolarics, Mohanraj Rajesh, Stephanie Federici, Edwin A Deitch, Sándor Bátkai, Pál Pacher, György Haskó
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6409 (2009)
BACKGROUND:Sepsis is a major healthcare problem and current estimates suggest that the incidence of sepsis is approximately 750,000 annually. Sepsis is caused by an inability of the immune system to eliminate invading pathogens. It was recently propo
Externí odkaz:
https://doaj.org/article/00cf65ea0c4f4255ba7d4f9cd06718c3
Autor:
Yong Qin, Patrick Morcillo, Geber Peña, Zoltán Spolarics, Anne C. Mosenthal, David H. Livingston
Publikováno v:
Inflammation. 43:370-381
Random X chromosome (ChrX) inactivation and consequent cellular mosaicism for the active ChrXs in white blood cells (WBCs) is unique to females and may contribute to sex-biased modulation of the innate immune response. Polymorphic differences between
Autor:
Sukhwinder Singh, Geber Peña, Yong Qin, Patrick Morcillo, Zoltán Spolarics, Anne C. Mosenthal, David H. Livingston
Publikováno v:
Shock
Common X-linked genetic polymorphisms are expected to alter cellular responses affecting males and females differently through sex-linked inheritance pattern as well as X chromosome (ChrX) mosaicism and associated ChrX skewing, which is unique to fem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e87049e079eb70bd8952cfb047983
https://europepmc.org/articles/PMC6952590/
https://europepmc.org/articles/PMC6952590/
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Most preclinical treatments for sepsis failed in clinical trials in part because the experimental models of sepsis were performed on healthy animals that do not mimic septic patients. Here, we report that experimental diabetes worsens glycemia, infla
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology
Frontiers in Immunology
Females have a longer lifespan and better general health than males. Considerable number of studies also demonstrated that, after trauma and sepsis, females present better outcomes as compared to males indicating sex-related differences in the innate
Autor:
Zoltán Spolarics
Publikováno v:
Critical care medicine. 45(11)
Autor:
Robert J. Donnelly, Zoltán Spolarics, Geber Peña, Ziad C. Sifri, Christina Michalski, Anne C. Mosenthal, David H. Livingston, Yong Qin
Publikováno v:
Shock (Augusta, Ga.). 47(4)
Sex-related outcome disparities following severe trauma have been demonstrated in human and animal studies; however, sex hormone status could not fully account for the differences. This study tested whether X-linked cellular mosaicism, which is uniqu
Autor:
James A. Thomas, Tripti Bishwas, Rachna Chandra, Zoltán Németh, Zoltán Spolarics, Stephanie Federici, Edwin A. Deitch
Publikováno v:
Inflammation. 36:1503-1512
Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may b
Autor:
Stephanie Federici, Pal Pacher, Rachna Chandra, Zoltan H. Nemeth, Zoltán Spolarics, Edwin A. Deitch, György Haskó, Béla Horváth
Publikováno v:
The Journal of Immunology. 186:6465-6473
Cellular X-chromosome mosaicism, which is unique to females, may be advantageous during pathophysiological challenges compared with the single X-chromosome machinery of males, and it may contribute to gender dimorphism in the inflammatory response. W
Autor:
Louis T. DiFazio, Zoltán Spolarics, Rolando H. Rolandelli, György Haskó, Zoltán Németh, Balázs Csóka
Publikováno v:
Journal of the American College of Surgeons. 225:e15