Zobrazeno 1 - 10
of 567
pro vyhledávání: '"Zoltán S."'
Autor:
Nariman Essmat, Anna Rita Galambos, Péter P. Lakatos, Dávid Árpád Karádi, Amir Mohammadzadeh, Sarah Kadhim Abbood, Orsolya Geda, Rudolf Laufer, Kornél Király, Pál Riba, Zoltán S. Zádori, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1115 (2023)
The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed. Herein, oral tolperisone, pregabalin, and duloxetine were tested for their antinociceptive effect
Externí odkaz:
https://doaj.org/article/154a5b30e75747f291e2a5926563b570
Autor:
Péter P. Lakatos, Dávid Árpád Karádi, Anna Rita Galambos, Nariman Essmat, Kornél Király, Rudolf Laufer, Orsolya Geda, Zoltán S. Zádori, Tamás Tábi, Mahmoud Al-Khrasani, Éva Szökő
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9564 (2022)
Current treatment approaches to manage neuropathic pain have a slow onset and their use is largely hampered by side-effects, thus there is a significant need for finding new medications. Tolperisone, a centrally acting muscle relaxant with a favorabl
Externí odkaz:
https://doaj.org/article/0b1611307c9a4634a73251f0b86306b8
Autor:
Barbara Hutka, Bernadette Lázár, András S. Tóth, Bence Ágg, Szilvia B. László, Nóra Makra, Balázs Ligeti, Bálint Scheich, Kornél Király, Mahmoud Al-Khrasani, Dóra Szabó, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce significant damage to the small intestine, which is accompanied by changes in intestinal bacteria (dysbiosis) and bile acids. However, it is still a question of debate whether besides m
Externí odkaz:
https://doaj.org/article/1b112fe01fa54c8a8ede6f8bf82c1b1e
Publikováno v:
Aerospace, Vol 9, Iss 1, p 3 (2021)
Promising low-noise aircraft architectures have been identified over the last few years at DLR. A set of DLR aircraft concepts was selected for further assessment in the context of sustainable and energy-efficient aviation and was established at the
Externí odkaz:
https://doaj.org/article/d32bb99072d6412090dfbc1c8003bbda
Autor:
Kornél Király, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, Susanna Fürst, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 26, Iss 20, p 6168 (2021)
The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the effectiveness of opioids. Nevertheless, dose escalation is required to maintain their analgesia,
Externí odkaz:
https://doaj.org/article/cdf053136d4f4abe8341753364e46a32
Autor:
Mihály Balogh, Ferenc Zádor, Zoltán S. Zádori, Mohammed Shaqura, Kornél Király, Amir Mohammadzadeh, Bence Varga, Bernadette Lázár, Shaaban A. Mousa, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Klára Gyires, Michael Schäfer, Susanna Fürst, Mahmoud Al-Khrasani
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Reduction of the opioid analgesia in diabetic neuropathic pain (DNP) results from μ-opioid receptor (MOR) reserve reduction. Herein, we examined the antinociceptive and antiallodynic actions of a novel opioid agonist 14-O-methymorphine-6-O-sulfate (
Externí odkaz:
https://doaj.org/article/8ef4a19c62184f1f8a16a5053b0dcdba
Autor:
Amir Mohammadzadeh, Péter P. Lakatos, Mihály Balogh, Ferenc Zádor, Dávid Árpád Karádi, Zoltán S. Zádori, Kornél Király, Anna Rita Galambos, Szilvia Barsi, Pál Riba, Sándor Benyhe, László Köles, Tamás Tábi, Éva Szökő, Laszlo G. Harsing, Mahmoud Al-Khrasani
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2479 (2021)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding
Externí odkaz:
https://doaj.org/article/78ce24478dcd4e6eb0152d1b4bcae416
Autor:
Susanna Fürst, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 25, Iss 11, p 2473 (2020)
There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is wel
Externí odkaz:
https://doaj.org/article/ccf64e1b1f134e5ab7211ab01a32dca6
Autor:
Ferenc Zádor, Amir Mohammadzadeh, Mihály Balogh, Zoltán S. Zádori, Kornél Király, Szilvia Barsi, Anna Rita Galambos, Szilvia B. László, Barbara Hutka, András Váradi, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Susanna Fürst, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 25, Iss 6, p 1370 (2020)
The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-s
Externí odkaz:
https://doaj.org/article/a3369a5ac33645918898849b78f5c94e
Autor:
Gábor B. Brenner, András Makkos, Csilla Terézia Nagy, Zsófia Onódi, Nabil V. Sayour, Tamás G. Gergely, Bernadett Kiss, Anikó Görbe, Éva Sághy, Zoltán S. Zádori, Bernadette Lázár, Tamás Baranyai, Richárd S. Varga, Zoltán Husti, András Varró, László Tóthfalusi, Rainer Schulz, István Baczkó, Zoltán Giricz, Péter Ferdinandy
Publikováno v:
Cells, Vol 9, Iss 3, p 551 (2020)
Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of ‘hidden cardiotoxicity’ is defined as cardiotoxicity of a drug that manifests in the
Externí odkaz:
https://doaj.org/article/e64b79f188254c80abf4399ea382fcad