Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zoltán Pethő"'
Autor:
Zoltán Pethő, Karolina Najder, Stephanie Beel, Benedikt Fels, Ilka Neumann, Sandra Schimmelpfennig, Sarah Sargin, Maria Wolters, Klavs Grantins, Eva Wardelmann, Miso Mitkovski, Andrea Oeckinghaus, Albrecht Schwab
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression triggers pancreatic stellate cells (PSCs)
Externí odkaz:
https://doaj.org/article/917ef2c5c0ad45b0bfab8102214a7f29
Autor:
Adam Feher, Zoltán Pethő, Tibor G. Szanto, Álmos Klekner, Gabor Tajti, Gyula Batta, Tibor Hortobágyi, Zoltan Varga, Albrecht Schwab, Gyorgy Panyi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Glioblastoma (GBM) is the most aggressive glial tumor, where ion channels, including KCa1.1, are candidates for new therapeutic options. Since the auxiliary subunits linked to KCa1.1 in GBM are largely unknown we used electrophysiology combi
Externí odkaz:
https://doaj.org/article/cf1b43ce89b54546b3b0602f8f0ca7fc
Autor:
Ferenc Papp, Gilman E. S. Toombes, Zoltán Pethő, Adrienn Bagosi, Adam Feher, János Almássy, Jesús Borrego, Ákos Kuki, Sándor Kéki, Gyorgy Panyi, Zoltan Varga
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fluorometry signals indicating conformational change in an ion channel are generated by quenching amino acids and lipid effects during movement of the dye relative to the plane of the membrane.
Externí odkaz:
https://doaj.org/article/7f7b2f17186c408295029866185e676f
Autor:
Simona Mareike Lüttgenau, Christin Emming, Thomas Wagner, Julia Harms, Justine Guske, Katrin Weber, Ute Neugebauer, Rita Schröter, Olga Panichkina, Zoltán Pethő, Florian Weber, Albrecht Schwab, Anja Kathrin Wege, Pavel Nedvetsky, Michael P. Krahn
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Abstract Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals
Externí odkaz:
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
Autor:
Karolina Najder, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The importance of the intracellular Ca2+ concentration ([Ca2+]i) in neutrophil function has been intensely studied. However, the role of the intracellular Na+ concentration ([Na+]i) which is closely linked to the intracellular Ca2+ regulation has bee
Externí odkaz:
https://doaj.org/article/0a3792d0f6b749b495e64f3695b5c8ac
Autor:
Sebastian, Fuest, Christoph, Post, Sebastian T, Balbach, Susanne, Jabar, Ilka, Neumann, Sandra, Schimmelpfennig, Sarah, Sargin, Elke, Nass, Thomas, Budde, Sareetha, Kailayangiri, Bianca, Altvater, Andreas, Ranft, Wolfgang, Hartmann, Uta, Dirksen, Claudia, Rössig, Albrecht, Schwab, Zoltán, Pethő
Publikováno v:
Cancers. 14(19)
Ewing sarcoma (EwS) is a rare and highly malignant bone tumor occurring mainly in childhood and adolescence. Physiologically, the bone is a central hub for Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae6c6fd1cff43de8a149076b77313f7f
https://pubmed.ncbi.nlm.nih.gov/36230742
https://pubmed.ncbi.nlm.nih.gov/36230742
Autor:
Albrecht Schwab, Christin Emming, Zoltán Pethő, Rita Schröter, Anja K. Wege, Pavel I. Nedvetsky, Julia Harms, Justine Guske, Simona Mareike Lüttgenau, Ute Neugebauer, Michael P. Krahn, Katrin Weber, Olga Panichkina, Thomas Wagner, Florian Weber
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Molecular Cancer
Molecular Cancer
Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68251a2d6690ffa704c97e9b102cd182
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
Autor:
Sarah Maskri, Etmar Bulk, Oliver Koch, Kathrin Brömmel, Zoltán Pethő, Bernhard Wünsch, Albrecht Schwab, Thomas Budde, Marius Rieke
Publikováno v:
Chemmedchem
The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was envis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ac8e0c506edd5a4f81776a7f26bda
http://europepmc.org/articles/PMC7756743
http://europepmc.org/articles/PMC7756743
Autor:
Marius Rieke, Zoltán Pethő, Sarah Maskri, Cristian A. Strassert, Christian Paul Konken, Oliver Koch, Iván Maisuls, Kathrin Brömmel, Bernhard Wünsch, Albrecht Schwab
Publikováno v:
Angewandte Chemie (International Ed. in English)
Small‐molecule probes for the in vitro imaging of KCa3.1 channel‐expressing cells were developed. Senicapoc, showing high affinity and selectivity for the KCa3.1 channels, was chosen as the targeting component. BODIPY dyes 15–20 were synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73497adb52d88b1d82fe664cb214b0b5
https://doi.org/10.1002/ange.202001201
https://doi.org/10.1002/ange.202001201
Publikováno v:
Cell Calcium. 80:79-90
In many cases, the mechanical properties of a tumor are different from those of the host tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their microenvironment, by altering cell migration, proliferation, extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb88e3a0490b9f244a1271c0443d76a
https://doi.org/10.1016/j.ceca.2019.03.007
https://doi.org/10.1016/j.ceca.2019.03.007