Quantitative PCR from human genomic DNA: The determination of gene copy numbers for congenital adrenal hyperplasia and RCCX copy number variation.

Autor: Márton Doleschall, Ottó Darvasi, Zoltán Herold, Zoltán Doleschall, Gábor Nyirő, Anikó Somogyi, Péter Igaz, Attila Patócs

Publikováno v: PLoS ONE, Vol 17, Iss 12, p e0277299 (2022)

Quantitative PCR (qPCR) is used for the determination of gene copy number (GCN). GCNs contribute to human disorders, and characterize copy number variation (CNV). The single laboratory method validations of duplex qPCR assays with hydrolysis probes o

Externí odkaz: https://doaj.org/article/d0f18af0b3f647a0823a14ed140882ca

MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes.

Autor: Péter K Jani, Erika Kajdácsi, Márton Megyeri, József Dobó, Zoltán Doleschall, Krisztina Futosi, Csaba I Tímár, Attila Mócsai, Veronika Makó, Péter Gál, László Cervenak

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87104 (2014)

Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this immediate anti-microbial action. We have previously shown that mannan-binding lectin-assoc

Externí odkaz: https://doaj.org/article/5dd880daea6345e4b28f9bd651d6ceb8

Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1

Autor: Péter K. Jani, Zsuzsanna Németh, Endre Schwaner, Erika Kajdácsi, János Rigó, Péter Gál, Tamás Hegedűs, Márta L. Debreczeni, József Dobó, Kinga András, László Cervenak, Zoltán Doleschall

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports

Mannan-binding lectin-associated serine protease 1 (MASP-1), the most abundant enzyme of the complement lectin pathway, is able to stimulate human umbilical vein endothelial cells (HUVECs) to alter the expression of several cytokines and adhesion mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaf2bba1943d033ca7d339dac95f39c
http://link.springer.com/article/10.1038/s41598-017-09058-8

Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility

Autor: David Ziupa, Heiko Bugger, Anna Ryan de Medeiros, Marius Menza, Corinna N. Lang, Stefanie Perez-Feliz, Jan C. Behrends, Michael Brunner, Naga Deepa Pantulu, Lea Mettke, Konstantin Michaelides, Zoltán Doleschall, Raphaela Rieke, Rémi Peyronnet, Geneviève Jolivet, Christoph Bode, Axel zur Hausen, Hannah E Fürniss, Ilona Bodi, Manfred Zehender, Katja E. Odening, Johannes Steinfurt, Gerlind Franke

Publikováno v: European Heart Journal
European Heart Journal, Oxford University Press (OUP): Policy B, 2019, 40 (10), pp.842-853. ⟨10.1093/eurheartj/ehy761⟩
European Heart Journal, 40(10), 842-853. Oxford University Press

AIMS Short-QT syndrome 1 (SQT1) is an inherited channelopathy with accelerated repolarization due to gain-of-function in HERG/IKr. Patients develop atrial fibrillation, ventricular tachycardia (VT), and sudden cardiac death with pronounced inter-indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11c471e972d6411e8038719e68b7b5c
https://hal.inrae.fr/hal-02619630

A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of theKCNE1gene

Autor: Stanley Nattel, Balázs Ördög, László Hiripi, Zsófia Kohajda, András Varró, György Seprényi, István Baczkó, András Horváth, Norbert Jost, Viktor Juhász, Maria Kovacs, Zsuzsanna Bősze, János Prorok, Katja E. Odening, P. Major, Zoltán Doleschall, László Virág

Publikováno v: British Journal of Pharmacology. 173:2046-2061

Background and purpose The reliable assessment of proarrhythmic risk of compounds under development remains an elusive goal. Current safety guidelines focus on the effects of blocking the KCNH2/HERG ion channel-in tissues and animals with intact repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2624db317d596dd36d3e7348ba775ff8
https://doi.org/10.1111/bph.13500