Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zoltán B. Szabó"'
Autor:
Szabolcs Sipos, Balázs Bálint, Zoltán B. Szabó, Levente Ondi, Márton Csékei, Zoltán Szlávik, Ágnes Proszenyák, James B. Murray, James Davidson, Ijen Chen, Pawel Dokurno, Allan E. Surgenor, Christopher Pedder, Roderick E. Hubbard, Ana-Leticia Maragno, Maia Chanrion, Frederic Colland, Olivier Geneste, András Kotschy
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 22073-22102 (2021)
Externí odkaz:
https://doaj.org/article/8920fac56cd04386b0126955f672d5f2
Autor:
I-Jen Chen, Proszenyák Ágnes, Zoltán B. Szabó, Levente Ondi, Csékei Márton, Olivier Geneste, Szabolcs Sipos, Allan E. Surgenor, Frédéric Colland, C. Pedder, Maïa Chanrion, Balázs Bálint, Ana-Leticia Maragno, Roderick E. Hubbard, Szlávik Zoltán, Pawel Dokurno, András Kotschy, James B. Murray, James R. Davidson
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 22073-22102 (2021)
ACS Omega
ACS Omega
Following the identification of thieno[2,3-d]pyrimidine-based selective and potent inhibitors of MCL-1, we explored the effect of core swapping at different levels of advancement. During hit-to-lead optimization, X-ray-guided S-N replacement in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a331e5552c24581a23a95aafbb773
https://doaj.org/article/8920fac56cd04386b0126955f672d5f2
https://doaj.org/article/8920fac56cd04386b0126955f672d5f2
Autor:
Ana-Leticia Maragno, Attila Paczal, András Kotschy, Didier Demarles, James Edward Paul Davidson, Szlávik Zoltán, Allan E. Surgenor, Gaëtane Le Toumelin-Braizat, James Murray, Proszenyák Ágnes, Frédéric Colland, Gabor Radics, Szabolcs Sipos, Olivier Geneste, Balázs Bálint, Csékei Márton, Zoltán B. Szabó, Pawel Dokurno, Audrey Claperon, Anne-Marie Girard, Chen I-Jen, Alain Bruno, Gaëlle Lysiak-Auvity, Roderick E. Hubbard, Maïa Chanrion, Zoe Daniels
Publikováno v:
Journal of medicinal chemistry. 63(22)
Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4627a227ab78ca732e02dade24b1f98
https://pubmed.ncbi.nlm.nih.gov/33146521
https://pubmed.ncbi.nlm.nih.gov/33146521
Autor:
Didier Demarles, James Edward Paul Davidson, Levente Ondi, Allan E. Surgenor, Frédéric Colland, Attila Paczal, Marion Zarka, Alan P. Robertson, Zoltán B. Szabó, András Kotschy, Julia Smith, Perron-Sierra Françoise, Gabor Radics, Audrey Claperon, Ben Davis, Pawel Dokurno, Szlávik Zoltán, Csékei Márton, Gaetane LeToumelin-Braizat, Roderick E. Hubbard, Chen I-Jen, C. Pedder, Olivier Geneste, James Murray, Nicolas Cauquil
Publikováno v:
Journal of medicinal chemistry. 62(15)
Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation when observed in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy, has emerged as an attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41342aba1a0624428d0d485578fc3d6
https://pubmed.ncbi.nlm.nih.gov/31339316
https://pubmed.ncbi.nlm.nih.gov/31339316
Autor:
James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled
Publikováno v:
Nature. 538:477-482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e7ae913cad44eb1a7aa5057ee9d4b1
https://doi.org/10.1038/nature19830
https://doi.org/10.1038/nature19830
Autor:
András Kotschy, Isabelle Theret, Attila Paczal, Frédéric De Ceuninck, Zoltán B. Szabó, Catherine Bernard, Alain Ktorza, Balázs Bálint, Csaba Wéber, Perron-Sierra Françoise, Levente Ondi
Publikováno v:
Journal of Medicinal Chemistry. 59:687-706
7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b2a87148aee12dcf7786d6b8e541f3
https://doi.org/10.1021/acs.jmedchem.5b01594
https://doi.org/10.1021/acs.jmedchem.5b01594
Autor:
Audrey Clapéron, Balázs Bálint, Chen I-Jen, Alain Bruno, Attila Paczal, Szlávik Zoltán, Zoltán B. Szabó, Ensar Halilovic, Heiko Maacke, Alix Derreal, James Edward Paul Davidson, Maïa Chanrion, Ana Leticia Maragno, Szabolcs Sipos, Fabienne Grave, Olivier Geneste, James Murray, Proszenyák Ágnes, Youzhen Wang, Natalia Matassova, Pawel Dokurno, Allan E. Surgenor, Csékei Márton, Prakash Mistry, András Kotschy, Gaëtane Le Toumelin-Braizat, Erick Morris, Frédéric Colland, Anne-Marie Girard, Gaëlle Lysiak-Auvity
Publikováno v:
Cancer Research. 79:4482-4482
Mcl-1 is highly expressed in a variety of human cancers (including those of hematopoietic and lymphoid origin) and is exploited by cancer cells to evade cell death and to develop resistance to diverse chemotherapeutic agents. We disclose, for the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b91a5136c91585a27738d6a4f9a0f527
https://doi.org/10.1158/1538-7445.am2019-4482
https://doi.org/10.1158/1538-7445.am2019-4482
Publikováno v:
Chirality. 16(4)
The CD spectra are reported for a series of 1,3-dioxane-type 4,6-O-(2'-naphthyl)methylene acetals of carbohydrates with and without interacting aromatic protective groups on the C-1, C-2, and C-3 hydroxy groups. In the absence of interacting chromoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36ea833d9416d488f436cb7181624d4a
https://pubmed.ncbi.nlm.nih.gov/15034907
https://pubmed.ncbi.nlm.nih.gov/15034907