Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zoja Soloviev"'
Autor:
Sapir Ofer, Fabian Blombach, Amanda M. Erkelens, Declan Barker, Zoja Soloviev, Samuel Schwab, Katherine Smollett, Dorota Matelska, Thomas Fouqueau, Nico van der Vis, Nicholas A. Kent, Konstantinos Thalassinos, Remus T. Dame, Finn Werner
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into ‘hypernucleosome’ particles of varying sizes
Externí odkaz:
https://doaj.org/article/bc8d288a4e11401aafac8f1923d0ab56
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1869(12)
Detailed characterization of protein reagents and biopharmaceuticals is key in defining successful drug discovery campaigns, aimed at bringing molecules through different discovery stages up to development and commercialization. There are many challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05da2b486515b5a78a7baa13c3bb4ce
https://pubmed.ncbi.nlm.nih.gov/34246790
https://pubmed.ncbi.nlm.nih.gov/34246790
Autor:
Zoja Soloviev, Joshua M.A. Bullock, Juliette M.B. James, Andrea C. Sauerwein, Joanne E. Nettleship, Raymond J. Owens, D. Flemming Hansen, Maya Topf, Konstantinos Thalassinos
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1870:140759
Human Histone Deacetylase 2 (HDAC2) belongs to a conserved enzyme superfamily that regulates deacetylation inside cells. HDAC2 is a drug target as it is known to be upregulated in cancers and neurodegenerative disorders. It consists of globular deace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a3ddf48566bf63d52afc8673e0d1b0
https://doi.org/10.1016/j.bbapap.2022.140759
https://doi.org/10.1016/j.bbapap.2022.140759
Autor:
Stephen J. Hill, Angela Bridges, Joelle Goulding, Peter D. Craggs, Zoja Soloviev, Charles S. Lay, Stephen J. Briddon
Publikováno v:
Cell Chemical Biology
Summary Interleukin-23 (IL-23) is a pro-inflammatory cytokine involved in the host defense against pathogens but is also implicated in the development of several autoimmune disorders. The IL-23 receptor has become a key target for drug discovery, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba397283a559b480608ecb748322ec6f
https://doi.org/10.1016/j.chembiol.2021.05.002
https://doi.org/10.1016/j.chembiol.2021.05.002
Autor:
Fabian, Blombach, Darya, Ausiannikava, Angelo Miguel, Figueiredo, Zoja, Soloviev, Tanya, Prentice, Mark, Zhang, Nanruoyi, Zhou, Konstantinos, Thalassinos, Thorsten, Allers, Finn, Werner
Publikováno v:
Nucleic Acids Research
The basal transcription factor TFE enhances transcription initiation by catalysing DNA strand-separation, a process that varies with temperature and ionic strength. Canonical TFE forms a heterodimeric complex whose integrity and function critically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::457b567482d66e99c196ac8c33e3b33d
https://pubmed.ncbi.nlm.nih.gov/29309690
https://pubmed.ncbi.nlm.nih.gov/29309690