DNA Interactions and Biological Activity of 2,9-Disubstituted 1,10-Phenanthroline Thiosemicarbazone-Based Ligands and a 4-Phenylthiazole Derivative

Autor: Álvaro Nicolás, Julia G. Quero, Marta Barroso, Zoila Gándara, Lourdes Gude

Publikováno v: Biology, Vol 13, Iss 1, p 60 (2024)

Four 1,10-phenanthroline derivatives (1–4) were synthesized as potential telomeric DNA binders, three substituted in their chains with thiosemicarbazones (TSCs) and one 4-phenylthiazole derivative. The compounds were characterized using NMR, HRMS,

Externí odkaz: https://doaj.org/article/c2b0f70e25b144158646bcba73cc9ac7

Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems

Autor: Zoila Gándara, Noelia Rubio, Rafael R. Castillo

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 351 (2023)

The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus p

Externí odkaz: https://doaj.org/article/693059aff0d74ebb985914082f10bddd

Easy Access to Polyfunctionalized Chiral Decalins

Autor: Uxía Gómez-Bouzó, Yagamare Fall, Generosa Gómez, Zoila Gándara, Hugo Santalla

Publikováno v: ACS Omega, Vol 5, Iss 40, Pp 26049-26055 (2020)
ACS Omega

An unexpected ring expansion that converts hydrindanes into decalins via an unprecedented dyotropic reaction involving a mesylate group has been observed, and this paved the way for easy access to polyfunctionalized chiral decalins. These polyfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fec9b7a9122f655266b63be4d94a5de
https://doaj.org/article/90168e26dfb44894bbacc4876bbf6d1c

Cytoprotective activities of kinetin purine isosteres

Autor: Dominik Vítek, Marek Zatloukal, Jiří Voller, Marian Hajduch, Miroslav Strnad, Beata Monfort, Libor Havlíček, Veronika Ručilová, Alena Kadlecová, Prashant Khirsariya, Gabriel Gonzalez, Kamil Paruch, Miroslav Soural, Barbara Maková, Václav Mik, Martina Medvedíková, Barbora Lišková, Benoît D'Autréaux, Zoila Gándara Barreiro

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2021, 33, pp.115993. ⟨10.1016/j.bmc.2021.115993⟩
Bioorganic and Medicinal Chemistry, 2021, 33, pp.115993. ⟨10.1016/j.bmc.2021.115993⟩

Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd9c8d687881f84bf5a1fe1e68f285b
https://pubmed.ncbi.nlm.nih.gov/33497938

Click chemistry approach to a series of calcitriol analogues with heterocyclic side chains

Autor: Zoila Gándara, Alioune Dior Fall, Massène Sène, Yagamare Fall, Ousmane Diouf, Pedro-Lois Suárez, Generosa Gómez, Mohamed Gaye

Publikováno v: Mediterranean Journal of Chemistry, Vol 5, Iss 2, Pp 423-433 (2016)

We report a straightforward synthesis of a series of novel calcitriol analogues from vitamin D2with some modification of the procedures described by Calverley and Choudhry. This approach allows the large scale synthesis of a late-stage intermediate c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcb70f8c21109653372f0737ea5c1ed
https://doi.org/10.13171/mjc52/016041430/gomez/fall