Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zoia Levashova"'
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9af9f3eb10a892b4846b80595d9a01
https://doi.org/10.1158/1535-7163.c.6537849.v1
https://doi.org/10.1158/1535-7163.c.6537849.v1
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Table S1. Screening Data; Supplementary Table S2. Binding Data; Supplementary Table S3. TGA Data; Supplementary Table S4. ADC Data With Ranking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db7bae4996febd810a10a32193713f
https://doi.org/10.1158/1535-7163.22504785
https://doi.org/10.1158/1535-7163.22504785
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab831a13a6726f0627401e143473ccb
https://doi.org/10.1158/1535-7163.22504788.v1
https://doi.org/10.1158/1535-7163.22504788.v1
Autor:
Allen G. Cai, Ryan Dorfman, Thi-Sau Migone, Avery Andrew, Sebastian Guelman, Cooper Anthony, Zoia Levashova, Jan-willem Theunissen, Maryam M. Bhatti
Publikováno v:
Molecular cancer therapeutics. 17(11)
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d114a6e46087c6a73c7738a64fa338
https://pubmed.ncbi.nlm.nih.gov/30126944
https://pubmed.ncbi.nlm.nih.gov/30126944
Autor:
Randall L. Halcomb, Amanda Valdiosera, David Y. Jackson, Lawrence Chinn, Jonathan S. Melnick, Migone Thi Sau, Mark R. Flory, Derrick Houser, Edward H. van der Horst, Maureen Fitch-Bruhns, Simeon Bowers, Edward Ha, Jorge Monteon, Jan Willem Theunissen, Gary Probst, Tiffany Wong, Paul W. Sauer, Zoia Levashova, Kristy Venstrom, Abel Bermudez, Sindy Liao-Chan, Christopher R. Behrens
Publikováno v:
Mol Pharm
Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883318e923b6b79e4a53f04cf24bb2c
https://doi.org/10.1021/acs.molpharmaceut.5b00432
https://doi.org/10.1021/acs.molpharmaceut.5b00432
Autor:
Michael G. Goris, Joseph M. Backer, Marina V. Backer, Francis G. Blankenberg, Zoia Levashova, Carl V. Hamby
Publikováno v:
Journal of Nuclear Medicine. 52:1630-1637
Tumor vessels abundantly express receptors for vascular endothelial growth factor (VEGF), despite treatment with conventional or antiangiogenic drugs. We wished to determine whether the high levels of VEGF receptor (VEGFR) within the tumor vasculatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15aaed8ea3ea50dc75a93f1dff2814
https://doi.org/10.2967/jnumed.111.091629
https://doi.org/10.2967/jnumed.111.091629
Autor:
Francis G. Blankenberg, Donald F. Gibson, Jonathan F. Tait, Ranjana Mehta, Christina Smith, Zoia Levashova
Publikováno v:
Bioconjugate Chemistry. 21:1554-1558
We developed a recombinant form of human annexin VI called annexin VI-601 (M(r) 76,224) with the N-terminal extension of Ala-Gly-Gly-Cys-Gly-His to allow ready attachment of fluorescent or radioactive labels. The protein was produced by expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf5bbc8469defd05ceabb199ab7dd61
https://doi.org/10.1021/bc100239k
https://doi.org/10.1021/bc100239k
Autor:
Francis G. Blankenberg, Marina V. Backer, Joseph M. Backer, John Pizzonia, Carl V. Hamby, Zoia Levashova
Publikováno v:
Journal of Nuclear Medicine. 51:959-966
Several drugs targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) are approved for cancer treatment. However, these drugs induce relatively modest and frequently unpredictable tumor responses. In this work, we explored whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07b640254e04f20076bcefa0fa78d30
https://doi.org/10.2967/jnumed.109.072199
https://doi.org/10.2967/jnumed.109.072199
Publikováno v:
Journal of Nuclear Medicine. 50:2058-2063
Angiogenesis plays a central role in the pathogenesis of chronic inflammatory disorders. Vascular endothelial growth factor (VEGF) and its receptors are the most important regulators of angiogenesis. We wished to determine whether labeled forms of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fab9ffa15cd070eabccfab36c98cf
https://doi.org/10.2967/jnumed.109.068023
https://doi.org/10.2967/jnumed.109.068023
Autor:
Maureen M. Tedesco, Francis G. Blankenberg, Ronald L. Dalman, Joseph M. Backer, Marina V. Backer, Joshua M. Spin, Mien Sho, Eiketsu Sho, Michael V. McConnell, Masahiro Terashima, Zoia Levashova
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1452-1457
Objective— Mural inflammation and neovascularization are characteristic pathological features of abdominal aortic aneurysm (AAA) disease. Vascular endothelial growth factor receptor (VEGFR) expression may also mediate AAA growth and rupture. We exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7633add5e3835d5c6b5f2f4603c9446e
https://doi.org/10.1161/atvbaha.109.187757
https://doi.org/10.1161/atvbaha.109.187757