Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Autor: Rongling Wang, Mario Gomez Salazar, Iris Pruñonosa Cervera, Amanda Coutts, Karen French, Marlene Magalhaes Pinto, Sabrina Gohlke, Ruben García-Martín, Matthias Blüher, Christopher J. Schofield, Ioannis Kourtzelis, Roland H. Stimson, Cécile Bénézech, Mark Christian, Tim J. Schulz, Elias F. Gudmundsson, Lori L. Jennings, Vilmundur G. Gudnason, Triantafyllos Chavakis, Nicholas M. Morton, Valur Emilsson, Zoi Michailidou

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte

Externí odkaz: https://doaj.org/article/1825f418498f427ea1d3d8694a180918

Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation

Autor: Iryna Pyrina, Kyoung-Jin Chung, Zoi Michailidou, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgiou

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates,

Externí odkaz: https://doaj.org/article/3236fe8d0116486497aabe703dd6c6c7

Hepatic choline deficiency underpins amelioration of visceral obesity and diabetes in ectonucleotide pyrophosphatase (Enpp)-6-/- mice

Autor: Katharina E. Schraut, Nicholas M. Morton, Zoi Michailidou, James F. Wilson, Scott Peter Webster, Roderick N. Carter, Rongling Wang, Katherine A. Kentistou

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bec471c1319ffa0bf5e4e92af60588d
https://doi.org/10.1530/endoabs.77.oc3.4

Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease

Autor: Mario Gomez-Salazar, Vasileia Ismini Alexaki, Zoi Michailidou

Publikováno v: Journal of innate immunity, 14(1):4-30
J Innate Immun
Journal of Innate Immunity, Pp 1-27 (2021)

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease, are characterized by chronic low-grade tissue and systemic inflammation. During obesity, the adipose tissue undergoes immunometabolic and functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2151d2d68e73ba4ef90554f2cf2ff1
https://repository.publisso.de/resource/frl:6439885

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Autor: Sergio Rodriguez-Cuenca, Gary A. Churchill, Antonio Vidal-Puig, Maximilian Zeyda, Nicholas M. Morton, Annalisa Gastaldello, Jasmina Beltram, Scott P. Webster, Gregor Gorjanc, Aila Saari, Thomas M. Stulnig, Simon Horvat, Vilmundur Gudnason, Roderick N. Carter, Matthew T G Gibbins, José Manuel Fernández-Real, Jonathan R. Seckl, Steven C. Munger, Clare McFadden, Gregorio Naredo, Martin E. Barrios-Llerena, Donald R. Dunbar, Christopher J Kenyon, Zhao V. Wang, Alexander F. Howie, Lynne Ramage, José María Moreno-Navarrete, Karen L. Svenson, Brian R. Walker, Valur Emilsson, Petra Sipilä, Zoi Michailidou, Rhona Aird

Publikováno v: Morton, N M, Beltram, J, Carter, R N, Michailidou, Z, Gorjanc, G, McFadden, C, Barrios-Llerena, M E, Rodriguez-Cuenca, S, Gibbins, M T G, Aird, R E, Moreno-Navarrete, J M, Munger, S C, Svenson, K L, Gastaldello, A, Ramage, L, Naredo, G, Zeyda, M, Wang, Z V, Howie, A F, Saari, A, Sipilä, P, Stulnig, T M, Gudnason, V, Kenyon, C J, Seckl, J R, Walker, B R, Webster, S P, Dunbar, D R, Churchill, G A, Vidal-Puig, A, Fernandez-Real, J M, Emilsson, V & Horvat, S 2016, ' Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness ', Nature Medicine, vol. 22, no. 7, pp. 771-779 . https://doi.org/10.1038/nm.4115
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
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The discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic 'lean' mouse model, which has been selected for low adiposit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d97883a5e7915270071cddd2f0f72e6
https://hdl.handle.net/2072/372198