Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zoheir Alayash"'
Autor:
Zoheir Alayash, Sebastian-Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Stefan Lars Reckelkamm, Michael Nolde
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
AimAn excessively activated or dysregulated complement system has been proven to be a vital contributor to the pathogenesis of periodontitis. It has been previously hypothesized that inhibiting the activity of complement component C5 by targeting the
Externí odkaz:
https://doaj.org/article/c146ab25608f4353964d4553a5bdeae0
Autor:
Michael Nolde, Zoheir Alayash, Stefan Lars Reckelkamm, Thomas Kocher, Benjamin Ehmke, Birte Holtfreter, Hansjörg Baurecht, Marios K. Georgakis, Sebastian-Edgar Baumeister
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
AimInterleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the development of periodontitis. While the inhibition of the IL-6 receptor using monoclonal antibodies is a well-established therapy for some diseases, so far, it
Externí odkaz:
https://doaj.org/article/cc16c2459b2048899a03f2c7facf5475
Autor:
Zoheir Alayash, Sebastian-Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Stefan Lars Reckelkamm, Michael Nolde
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
AimTo investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis.Materials and methodsGenetic instruments were selected from the vicinity of TNFR superfamily member 1A (TNFRSF1A)
Externí odkaz:
https://doaj.org/article/3d7b081bedd040eb9f0c4c0ecfb11483
Autor:
Michael Nolde, Birte Holtfreter, Thomas Kocher, Zoheir Alayash, Stefan Lars Reckelkamm, Benjamin Ehmke, Hansjörg Baurecht, Sebastian-Edgar Baumeister
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundObservational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.MethodsThe study used summary statistics from publ
Externí odkaz:
https://doaj.org/article/f5d3e6a67e9e4cff824eec4a69c87cb3
Autor:
Sebastian‐Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Daniel Hagenfeld, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjörg Baurecht, Michael Nolde
Publikováno v:
Journal of Periodontology. 94:616-621
Autor:
Sebastian‐Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjörg Baurecht, Michael Nolde
Publikováno v:
Journal of Clinical Periodontology. 50:114-120
Epidemiological and pre-clinical studies suggest a chemoprotective role of lipid-lowering agents in periodontitis. We tested the association of genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), Niemann-Pick C1
Autor:
Stefan Lars Reckelkamm, Anke Hannemann, Thomas Kocher, Matthias Nauck, Henry Völzke, Benjamin Ehmke, Martina Rauner, Zoheir Alayash, Sebastian‐Edgar Baumeister, Michael Nolde, Birte Holtfreter
Publikováno v:
Journal of Clinical Periodontology. 49:633-641
To examine the associations between bone turnover markers and periodontitis in two cross-sectional population-based studies.We used data from two independent adult samples (N = 4993), collected within the Study of Health in Pomerania project, to anal
Autor:
Zoheir Alayash, Sebastian-Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Michael Nolde, Stefan Lars Reckelkamm
AimEvidence from a phase IIa trial showed that a complement C3-targeted drug reduced gingival inflammation in patients with gingivitis. We investigated the therapeutic effect of genetically proxied C3 inhibition on periodontitis using drug target Men
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d0aea757062e823afa168278e33928
https://doi.org/10.1101/2023.02.13.23285838
https://doi.org/10.1101/2023.02.13.23285838
Autor:
Michael Nolde, Zoheir Alayash, Stefan Lars Reckelkamm, Thomas Kocher, Benjamin Ehmke, Birte Holtfreter, Hansjörg Baurecht, Marios K. Georgakis, Sebastian-Edgar Baumeister
Interleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the development of periodontitis. To explore whether downregulation of IL-6 signaling could represent a viable treatment target for periodontitis, we tested the assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f51ce85f561a405c1cd305f6d902e3fe
https://doi.org/10.1101/2022.12.22.22283849
https://doi.org/10.1101/2022.12.22.22283849
Autor:
Zoheir Alayash, Sebastian‐Edgar Baumeister, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Michael Nolde
Publikováno v:
Journal of periodontologyREFERENCES.
The purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian randomization (MR) analysis.We used 81 single nucleotide polymorphisms (SNPs) associated with BMD at a p-value of5