Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Zohar Yakhini"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Data storage in DNA has recently emerged as a promising archival solution, offering space-efficient and long-lasting digital storage solutions. Recent studies suggest leveraging the inherent redundancy of synthesis and sequencing technologie
Externí odkaz:
https://doaj.org/article/f6a312ef61324ede85c41157b2b0f6dd
Publikováno v:
Biology, Vol 13, Iss 3, p 175 (2024)
Traditional gene set enrichment analysis falters when applied to large genomic domains, where neighboring genes often share functions. This spatial dependency creates misleading enrichments, mistaking mere physical proximity for genuine biological co
Externí odkaz:
https://doaj.org/article/e7c22cc9f0aa45efb1c038df0991540d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Excision tissue biopsy, while central to cancer treatment and precision medicine, presents risks to the patient and does not provide a sufficiently broad and faithful representation of the heterogeneity of solid tumors. Here we introduce e-b
Externí odkaz:
https://doaj.org/article/8cc44bf558434fbd84f52a513ef83fd2
Autor:
Ariel Berl, Ofir Shir-Az, Ilai Genish, Hadas Biran, Din Mann, Amrita Singh, Julia Wise, Vladimir Kravtsov, Debora Kidron, Alexander Golberg, Edward Vitkin, Zohar Yakhini, Avshalom Shalom
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293744 (2023)
Basal cell carcinoma (BCC) is the most common type of skin cancer. Due to multiple, potential underlying molecular tumor aberrations, clinical treatment protocols are not well-defined. This study presents multisite molecular heterogeneity profiles of
Externí odkaz:
https://doaj.org/article/7c35f1106dc24f84a2101db9a7e99b6a
Autor:
Ido Amit, Ortal Iancu, Alona Levy-Jurgenson, Gavin Kurgan, Matthew S. McNeill, Garrett R. Rettig, Daniel Allen, Dor Breier, Nimrod Ben Haim, Yu Wang, Leon Anavy, Ayal Hendel, Zohar Yakhini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here the authors present CRISPECTOR, a software tool to detect, evaluate and quantify editing activity, including translocations, from NGS data.
Externí odkaz:
https://doaj.org/article/a5eef4e669634506b9f9db24ef9fe0fe
Autor:
Noa Katz, Eitamar Tripto, Naor Granik, Sarah Goldberg, Orna Atar, Zohar Yakhini, Yaron Orenstein, Roee Amit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Phage-coat proteins can be used to build synthetic biology parts. Here the authors use an oligo library and machine learning to predict and verify sequences based on binding scores.
Externí odkaz:
https://doaj.org/article/9616667022114a1680b5c585955aa3b8
Autor:
Jenny Shapiro, Ortal Iancu, Ashley M. Jacobi, Matthew S. McNeill, Rolf Turk, Garrett R. Rettig, Ido Amit, Adi Tovin-Recht, Zohar Yakhini, Mark A. Behlke, Ayal Hendel
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1097-1107 (2020)
Genome editing of human cluster of differentiation 34+ (CD34+) hematopoietic stem and progenitor cells (HSPCs) holds great therapeutic potential. This study aimed to optimize on-target, ex vivo genome editing using the CRISPR-Cas9 system in CD34+ HSP
Externí odkaz:
https://doaj.org/article/74189cca19364566b5cb4597df8b7115
Autor:
Ilai Genish, Batel Gabay, Angela Ruban, Yona Goldshmit, Amrita Singh, Julia Wise, Klimentiy Levkov, Avshalom Shalom, Edward Vitkin, Zohar Yakhini, Alexander Golberg
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0265866 (2022)
A major concern in tissue biopsies with a needle is missing the most lethal clone of a tumor, leading to a false negative result. This concern is well justified, since needle-based biopsies gather tissue information limited to needle size. In this wo
Externí odkaz:
https://doaj.org/article/5d678503cc6e434a80d87341bad88560
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009805 (2021)
RNA splicing is a key process in eukaryotic gene expression, in which an intron is spliced out of a pre-mRNA molecule to eventually produce a mature mRNA. Most intron-containing genes are constitutively spliced, hence efficient splicing of an intron
Externí odkaz:
https://doaj.org/article/5ba94e676d774c43b1a50c724747047d
Publikováno v:
Sensors, Vol 22, Iss 16, p 6306 (2022)
Analysing human physiological data allows access to the health state and the state of mind of the subject individual. Whenever a person is sick, having a panic attack, happy or scared, physiological signals will be different. In terms of physiologica
Externí odkaz:
https://doaj.org/article/acc037afd1a5431d87de0074b3dcf932