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Multifaceted Modulation of K+ Channels by Protein-tyrosine Phosphatase ϵ Tunes Neuronal Excitability

Autor: Polina Kornilov, Sharon Ebner-Bennatan, Zohar Tiran, Eti Patrich, Ari Elson, Asher Peretz, Bernard Attali

Publikováno v: Journal of Biological Chemistry. 287:27614-27628

Non-receptor-tyrosine kinases (protein-tyrosine kinases) and non-receptor tyrosine phosphatases (PTPs) have been implicated in the regulation of ion channels, neuronal excitability, and synaptic plasticity. We previously showed that protein-tyrosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4869d94dc30593dd7e1d9e98fad23e
https://doi.org/10.1074/jbc.m112.342519

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A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization

Autor: John S. Penn, Zongmin Zhou, Ofer Levy, Megan E. Capozzi, C. Coletta, Andreas Papapetropoulos, Mark W. Dewhirst, Anastasia Pyriochou, Galit Rotman, Yossef Kliger, Won Park, Gregory M. Palmer, Itamar Borukhov, Zohar Tiran

Publikováno v: British Journal of Pharmacology. 165:1891-1903

BACKGROUND AND PURPOSE Pathological angiogenesis is associated with various human diseases, such as cancer, autoimmune diseases and retinopathy. The angiopoietin (Ang)–Tie2 system plays critical roles in several steps of angiogenic remodelling. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61539979eb75df55b6b3041c03c0227a
https://doi.org/10.1111/j.1476-5381.2011.01677.x

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A Novel Recombinant Soluble Splice Variant of Met Is a Potent Antagonist of the Hepatocyte Growth Factor/Scatter Factor-Met Pathway

Publikováno v: Clinical Cancer Research. 14:4612-4621

Purpose: The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), are involved in a wide range of biological activities, including cell proliferation, motility, invasion, and angiogenesis. The HGF/SF-Met sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599fa74040dc8597b9d3c5a2cc64fe1e
https://doi.org/10.1158/1078-0432.ccr-08-0108

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Dimerization In Vivo and Inhibition of the Nonreceptor Form of Protein Tyrosine Phosphatase Epsilon

Autor: Gidi Shani, Tal Sines, Jeroen den Hertog, Zohar Tiran, Ari Elson, Hila Toledano-Katchalski, Shira Granot-Attas

Publikováno v: Molecular and Cellular Biology. 23:5460-5471

cyt-PTP epsilon is a naturally occurring nonreceptor form of the receptor-type protein tyrosine phosphatase (PTP) epsilon. As such, cyt-PTP epsilon enables analysis of phosphatase regulation in the absence of extracellular domains, which participate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4686f3adc75e98cb653f51d69129d230
https://doi.org/10.1128/mcb.23.15.5460-5471.2003

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Phosphorylation-dependent Regulation of Kv2.1 Channel Activity at Tyrosine 124 by Src and by Protein-tyrosine Phosphatase ε

Autor: Ari Elson, Asher Peretz, Zohar Tiran, Bernard Attali

Publikováno v: Journal of Biological Chemistry. 278:17509-17514

Voltage-gated potassium (Kv) channels are a complex and heterogeneous family of proteins that play major roles in brain and cardiac excitability. Although Kv channels are activated by changes in cell membrane potential, tyrosine phosphorylation of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0adf2f51a92785c53a3855ebfbdb13
https://doi.org/10.1074/jbc.m212766200

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Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept

Autor: Avi Rosenberg, Dani Eshel, Ofer Levy, Zurit Levine, Anat Oren, Yossef Kliger, Yossi Cohen, Zohar Tiran, Claudia A. Nold-Petry, Itamar Borukhov, Assaf Wool, Ehud Schreiber, Haim Ashkenazy, Anat Amir, Amit Novik, Charles A. Dinarello, Amir Toporik

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(33)

Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the formation of helix–helix interactions in viral envelope prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f0aaef3d74d99710618e10d59fa239
https://pubmed.ncbi.nlm.nih.gov/19666568

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Abstract B291: Identification of novel immune checkpoints and their implementation as mAb targets for cancer immunotherapy

Autor: Gady Cojocaru, Liat Dassa, Amit Novik, Nora Tarcic, Ofer Levy, Tania Pergan, Joseph R. Podojil, Zurit Levine, Amir Toporik, Eyal Neria, Shirley Sameah-Greenwald, Iris Hecht, Anat Oren, Ilan Vaknin, Zohar Tiran, Sergey Nemzer, Peter Steinberger, Galit Rotman

Publikováno v: Molecular Cancer Therapeutics. 12:B291-B291

Immune checkpoints, such as CTLA4 and PD-1, have emerged as promising drug targets for cancer immunotherapy. We hypothesize that additional novel members of the B7/CD28 family play a role in T cell regulation and thus may serve as targets for therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58cd98fa378997303b653232d5c3bba3
https://doi.org/10.1158/1535-7163.targ-13-b291

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Tyrosine Phosphatases ε and α Perform Specific and Overlapping Functions in Regulation of Voltage-gated Potassium Channels in Schwann Cells

Autor: Asher Peretz, Ari Elson, Bernard Attali, Jan Sap, Vera Shinder, Zohar Tiran, Tal Sines

Tyrosine phosphatases (PTPs) epsilon and alpha are closely related and share several molecular functions, such as regulation of Src family kinases and voltage-gated potassium (Kv) channels. Functional interrelationships between PTPepsilon and PTPalph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffc0fb6957aca3bcf8adfbf48e5f2d5
https://europepmc.org/articles/PMC1635364/

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