Výsledky vyhledávání - "Zohal Ghulam-Jhelani"

Akademický článek

Early deficits in GABA inhibition parallels an increase in L-type Ca2+ currents in the jaw motor neurons of SOD1G93A mouse model for ALS

Autor: Sharmila Venugopal, Zohal Ghulam-Jhelani, In Sook Ahn, Xia Yang, Martina Wiedau, Dwayne Simmons, Scott H. Chandler

Publikováno v: Neurobiology of Disease, Vol 177, Iss , Pp 105992- (2023)

Amyotrophic Lateral Sclerosis (ALS) involves protracted pre-symptomatic periods of abnormal motor neuron (MN) excitability occurring in parallel with central and peripheral synaptic perturbations. Focusing on inhibitory control of MNs, we first compa

Externí odkaz: https://doaj.org/article/38a64488b867408eb05971fb6145ea22

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Diminished GAD67 Terminals and Ambient GABA Inhibition Associated with Reduced Motor Neuron Recruitment Threshold in the SOD1G93A ALS mouse

Autor: Sharmila Venugopal, Zohal Ghulam-Jhelani, Dwayne Simmons, Scott H Chandler

Pre-symptomatic studies in mouse models of the neurodegenerative motor neuron (MN) disease, Amyotrophic Lateral Sclerosis (ALS) highlight early alterations in intrinsic and synaptic excitability and have supported an excitotoxic theory of MN death. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a37da43cea7604acebccf5fa786d5893
https://doi.org/10.1101/2021.12.16.473041

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