SLC30A10 Mutation Involved in Parkinsonism Results in Manganese Accumulation within Nanovesicles of the Golgi Apparatus.

Autor: Carmona A; Chemical Imaging and Speciation, CENBG , University of Bordeaux , UMR 5797, 33175 Gradignan , France.; CNRS, IN2P3 , CENBG , UMR 5797, 33175 Gradignan , France., Zogzas CE; Division of Pharmacology and Toxicology; Institute for Cellular and Molecular Biology and Institute for Neuroscience , University of Texas , Austin , Texas 78712 , United States., Roudeau S; Chemical Imaging and Speciation, CENBG , University of Bordeaux , UMR 5797, 33175 Gradignan , France.; CNRS, IN2P3 , CENBG , UMR 5797, 33175 Gradignan , France., Porcaro F; Chemical Imaging and Speciation, CENBG , University of Bordeaux , UMR 5797, 33175 Gradignan , France.; CNRS, IN2P3 , CENBG , UMR 5797, 33175 Gradignan , France., Garrevoet J; Deutsches Elektronen Synchrotron DESY , Notkestr. 85 , Hamburg 22607 , Germany., Spiers KM; Deutsches Elektronen Synchrotron DESY , Notkestr. 85 , Hamburg 22607 , Germany., Salomé M; European Synchrotron Radiation Facility , 38000 Grenoble , France., Cloetens P; European Synchrotron Radiation Facility , 38000 Grenoble , France., Mukhopadhyay S; Division of Pharmacology and Toxicology; Institute for Cellular and Molecular Biology and Institute for Neuroscience , University of Texas , Austin , Texas 78712 , United States., Ortega R; Chemical Imaging and Speciation, CENBG , University of Bordeaux , UMR 5797, 33175 Gradignan , France.; CNRS, IN2P3 , CENBG , UMR 5797, 33175 Gradignan , France.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2019 Jan 16; Vol. 10 (1), pp. 599-609. Date of Electronic Publication: 2018 Oct 15.

Inherited Disorders of Manganese Metabolism.

Autor: Zogzas CE; Division of Pharmacology & Toxicology, College of Pharmacy; Institute for Cellular & Molecular Biology; and Institute for Neuroscience, The University of Texas at Austin, 3.510E BME, 107 W. Dean Keeton, Austin, TX, 78712, USA., Mukhopadhyay S; Division of Pharmacology & Toxicology, College of Pharmacy; Institute for Cellular & Molecular Biology; and Institute for Neuroscience, The University of Texas at Austin, 3.510E BME, 107 W. Dean Keeton, Austin, TX, 78712, USA. som@austin.utexas.edu.

Publikováno v: Advances in neurobiology [Adv Neurobiol] 2017; Vol. 18, pp. 35-49.

The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.

Autor: Gay DC; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States., Wagner DT; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States., Meinke JL; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States., Zogzas CE; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States., Gay GR; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States., Keatinge-Clay AT; Department of Molecular Biosciences, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0165, United States; Department of Chemistry, The University of Texas at Austin, 1 University Station A5300, Austin, TX 78712-0165, United States. Electronic address: adriankc@utexas.edu.

Publikováno v: Journal of structural biology [J Struct Biol] 2016 Mar; Vol. 193 (3), pp. 196-205. Date of Electronic Publication: 2015 Dec 23.

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.

Autor: Leyva-Illades D; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Chen P; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, and., Zogzas CE; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Hutchens S; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Mercado JM; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Swaim CD; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Morrisett RA; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701., Bowman AB; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-8552., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, and michael.aschner@einstein.yu.edu som@austin.utexas.edu., Mukhopadhyay S; Division of Pharmacology and Toxicology, College of Pharmacy, Institutes for Cellular and Molecular Biology and for Neuroscience, University of Texas at Austin, Austin, Texas 78701, michael.aschner@einstein.yu.edu som@austin.utexas.edu.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Oct 15; Vol. 34 (42), pp. 14079-95.