Výsledky vyhledávání - "Zofia Warminska"

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

Autor: Renata Kasprzyk, Natalia Kleczewska, Natalia Baran, Zofia Warminska, Aneta Karpinska, Joanna Kowalska, Robert Hołyst, Jaroslaw Michalski, Jacek Jemielity, Karina Kwapiszewska, Pawel J. Sikorski, Lukasz Markiewicz

Publikováno v: Chemical Science

Targeting cap-dependent translation initiation is one of the experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5′,5′-triphosphates cap analogs are potent antagonists of eukaryotic tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864cde7229a5f51800715db94df3bd41
https://doi.org/10.1039/d1sc02143e

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Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses

Autor: Ewa M. Kosciuczuk, Zofia Warminska, Eleanor N. Fish, Diana Saleiro, Barbara Kroczynska, Leonidas C. Platanias, Swarna Mehrotra, Gavin T. Blyth, Jacek Jemielity, Robert L. Rafidi, Ahmet Dirim Arslan, Beata Majchrzak-Kita

Publikováno v: Journal of Biological Chemistry. 291:2389-2396

We provide evidence for a unique pathway engaged by the type II IFN receptor, involving mTORC2/AKT-mediated downstream regulation of mTORC1 and effectors. These events are required for formation of the eukaryotic translation initiation factor 4F comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527b5fd54063d55be496e6d513645503
https://doi.org/10.1074/jbc.m115.664995

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mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

Autor: Jacek Jemielity, Marcin Warminski, Zofia Warminska, Joanna Kowalska

Publikováno v: European Journal of Organic Chemistry. 2015:6153-6169

A simple and efficient synthesis of dinucleotide mRNA 5′ cap analogues functionalised by the addition of an amine or carboxylic acid group onto one of the ribose rings is reported. Selection of the modification sites was dictated by the recognition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ada19d628aeb51b6ae5fcc1754c571
https://doi.org/10.1002/ejoc.201500672

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Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA

Autor: Pawel J. Sikorski, Marcin Warminski, Zofia Warminska, Anna Kropiwnicka, Maciej Lukaszewicz, Edward Darzynkiewicz, Joanna Kowalska, Joanna Zuberek, Jacek Jemielity

Publikováno v: Bioconjugate chemistry. 28(7)

mRNA is a template for protein biosynthesis, and consequently mRNA transport, translation, and turnover are key elements in the overall regulation of gene expression. Along with growing interest in the mechanisms regulating mRNA decay and localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f97f0bab69136e3fa24aa3a1b2477c0
https://pubmed.ncbi.nlm.nih.gov/28613834

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mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation (Eur. J. Org. Chem. 28/2015)

Autor: Jacek Jemielity, Zofia Warminska, Joanna Kowalska, Marcin Warminski

Publikováno v: European Journal of Organic Chemistry. 2015

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48aabe4261786f586f0078a93409a005
https://doi.org/10.1002/ejoc.201590079

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