Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Zofia Mazerska"'
Autor:
Tomasz Laskowski, Michał Kosno, Witold Andrałojć, Joanna E. Frackowiak, Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Nikola Radoń, Maria Świerżewska, Anna Woźny, Ewa Paluszkiewicz, Zofia Mazerska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the ring systems is an imidazoacridinone moiety, with the ske
Externí odkaz:
https://doaj.org/article/b86a65dc604446ca99c39fb296840082
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 791-798 (2021)
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. T
Externí odkaz:
https://doaj.org/article/af970ca62e2d4b51a1bbec8871eb1181
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 4, Pp 376-384 (2020)
5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharma
Externí odkaz:
https://doaj.org/article/48a49dfb8c9d4316a3e02459773ba5a2
Autor:
Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
Publikováno v:
Molecules, Vol 27, Iss 13, p 3995 (2022)
Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nu
Externí odkaz:
https://doaj.org/article/a1af03541ea746f7ab40cf5703d38fc1
Autor:
Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potęga, Monika Pawłowska, Michał Kosno, Ewa Augustin, Zofia Mazerska
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 317 (2021)
New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respe
Externí odkaz:
https://doaj.org/article/33875ddea39b432b90bf1e1d31950aa1
Autor:
Zofia Bernat, Anna Mieszkowska, Zofia Mazerska, Joanna Matysiak, Zbigniew Karczmarzyk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Publikováno v:
Applied Sciences, Vol 11, Iss 6, p 2660 (2021)
Referring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazin
Externí odkaz:
https://doaj.org/article/6dd85e31778c41e8a17c0d7d82c75ff0
Autor:
Magdalena Niemira, Barbara Borowa-Mazgaj, Samuel B. Bader, Adrianna Moszyńska, Marcin Ratajewski, Kaja Karaś, Mirosław Kwaśniewski, Adam Krętowski, Zofia Mazerska, Ester M. Hammond, Anna Skwarska
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 292 (2020)
The androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and metastasis. Thus, blocking AR activity and its downstream signaling constitutes a major strategy for PCa treatment. Here, we report on the potent anti-PCa activ
Externí odkaz:
https://doaj.org/article/9885726c812f483fb11fc972b9426358
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3954 (2020)
Activity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C
Externí odkaz:
https://doaj.org/article/3029e9d7cee047eeab92d9ff00d226a0
Publikováno v:
Molecules, Vol 23, Iss 12, p 3226 (2018)
Bisphenol A (BPA) is one of the most popular and commonly used plasticizer in the industry. Over the past decade, new chemicals that belong to the bisphenol group have increasingly been used in industrial applications as alternatives to BPA. Neverthe
Externí odkaz:
https://doaj.org/article/b09fd2242e73489cbc44ab3bd1affdbc
Autor:
Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
Unsymmetrical bisacridines (UAs), which represent a novel group of anticancer agents, were previously synthesized by our group. Our recent studies have shown high antitumor potential of UAs against multiple cancer cell lines and human tumor xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40dbbb5292b0b59b3a5232d36ad49508
https://doi.org/10.21203/rs.3.rs-1579934/v1
https://doi.org/10.21203/rs.3.rs-1579934/v1