Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zofia M. Lasiecka"'
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
The clinical and pathological progression of Alzheimer's disease often proceeds rapidly, but little is understood about its structural characteristics over short intervals. This study evaluated the short temporal characteristics of the brain structur
Externí odkaz:
https://doaj.org/article/06e5a9a9d4f24169a987ddda3e3e972f
Autor:
André M. Miranda, Zofia M. Lasiecka, Yimeng Xu, Jessi Neufeld, Sanjid Shahriar, Sabrina Simoes, Robin B. Chan, Tiago Gil Oliveira, Scott A. Small, Gilbert Di Paolo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested ma
Externí odkaz:
https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c0
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 11 (2020)
Frontiers in Neurology, Vol 11 (2020)
The clinical and pathological progression of Alzheimer's disease often proceeds rapidly, but little is understood about its structural characteristics over short intervals. This study evaluated the short temporal characteristics of the brain structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffb08725ae5cfbf4a5e0d717ba3da2b
https://pubmed.ncbi.nlm.nih.gov/32425868
https://pubmed.ncbi.nlm.nih.gov/32425868
Autor:
Zofia M, Lasiecka, Bettina, Winckler
Publikováno v:
Methods in cell biology. 131
Endosomes play critical roles on regulating surface receptor levels as well as signaling cascades in all cell types, including neurons. Endocytosis and endosomal trafficking is routinely studied after fixation, but live imaging is increasingly being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3dee2054270be7eda11617546f3184ff
https://pubmed.ncbi.nlm.nih.gov/26794525
https://pubmed.ncbi.nlm.nih.gov/26794525
Autor:
Bettina Winckler, Zofia M. Lasiecka
Endosomes play critical roles on regulating surface receptor levels as well as signaling cascades in all cell types, including neurons. Endocytosis and endosomal trafficking is routinely studied after fixation, but live imaging is increasingly being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2713f4e42d7e2016960ecb85ac4fbfc
https://doi.org/10.1016/bs.mcb.2015.07.002
https://doi.org/10.1016/bs.mcb.2015.07.002
Publikováno v:
The Journal of Neuroscience. 30:16485-16497
In neurons, the endosomal system is essential for membrane receptor trafficking to dendrites and axons and thereby participates in various neuronal functions, such as neurite outgrowth and synaptic plasticity. A multitude of regulators coordinates tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7086e43f40923ee334cc0ade7477c7
https://doi.org/10.1523/jneurosci.3127-10.2010
https://doi.org/10.1523/jneurosci.3127-10.2010
Autor:
Witold Konopka, Evgeni V. Nikolaev, Barbara Mioduszewska, Zofia M. Lasiecka, Marcin Wawrzyniak, Filip A. Konopacki, Grzegorz M. Wilczynski, Dorota Owczarek, Adam Gorlewicz, Kamila Duniec, Piotr Michaluk, Leszek Kaczmarek, Ole Petter Ottersen, Pawel Okulski, Werner Zuschratter, Dariusz C. Górecki, Ewa Wilczek, Monika Malinowska, Agnieszka Walczak, Lukasz Kolodziej
Publikováno v:
The Journal of Cell Biology
Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme and a key pathogenic factor in two animal models of TLE: kainate-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadb0191d1831f4153b8f30dc3a332cf
https://doi.org/10.1083/jcb.200708213
https://doi.org/10.1083/jcb.200708213
Autor:
Judith Klumperman, Harald Hirling, Johanna T. Cannon, Pekka Kujala, Zofia M. Lasiecka, Bettina Winckler, Dolora Wisco, Chan Choo Yap, Michael C. Chang
Publikováno v:
The Journal of Cell Biology
Correct targeting of proteins to axons and dendrites is crucial for neuronal function. We showed previously that axonal accumulation of the cell adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) depends on endocytosis (Wisco, D., E.D. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db74a0bef23f075fa167c95e905f524
https://doi.org/10.1083/jcb.200707143
https://doi.org/10.1083/jcb.200707143
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(44)
The function of endosomes is intricately linked to cellular function in all cell types, including neurons. Intriguingly, neurons express cell type-specific proteins that localize to endosomes, but little is known about how these neuronal proteins int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53732a3e3d1d890243f55c3bab672808
https://pubmed.ncbi.nlm.nih.gov/25355216
https://pubmed.ncbi.nlm.nih.gov/25355216
Autor:
Ruth L. Stornetta, Jaideep Kapur, John Williamson, Kyle A. Sullivan, Zofia M. Lasiecka, Iuliia Vitko, Veit-Simon Eckle, Edward Perez-Reyes, Deblina Dey, Bettina Winckler
In 1964, the International League Against Epilepsy (ILAE) defined status epilepticus (SE) as a seizure that “persists for a sufficient length of time or is repeated frequently enough to produce a fixed and enduring epileptic condition.”1 The Neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f62bba25a8416274abb746feba53e5
https://europepmc.org/articles/PMC4161023/
https://europepmc.org/articles/PMC4161023/