Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zoe Yuen-Kiu Choi"'
Autor:
Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho, Philip Wing-Lok Ho
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to mitophagy initiatio
Externí odkaz:
https://doaj.org/article/982bf080882144a892ab9cf7094a418c
Autor:
Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Shirley Yin-Yu Pang, Zoe Yuen-Kiu Choi, Yingmin Liang, Weng Seng Lai, Yuefei Ruan, Kenneth Mei-Yee Leung, Susan Yung, Judith Choi-Wo Mak, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic α-synuclein (αSyn) aggregate/oligomer accumulation. LRRK2 hyperactivity is a disease-modif
Externí odkaz:
https://doaj.org/article/2e279dd54a294707af03424d9d6a60c0
Autor:
Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-19 (2022)
Abstract Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarities between LRRK2-assoc
Externí odkaz:
https://doaj.org/article/06ce894a7bfb40c5b4c49bef2bb50a60
Autor:
Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are a
Externí odkaz:
https://doaj.org/article/b6fc3201296c4ede996e68a53646446e
Autor:
Philip Wing‐Lok Ho, Lingfei Li, Hui‐Fang Liu, Zoe Yuen‐Kiu Choi, Eunice Eun Seo Chang, Shirley Yin‐Yu Pang, Yasine Malki, Chi‐Ting Leung, Michelle Hiu‐Wai Kung, David Boyer Ramsden, Shu‐Leong Ho
Publikováno v:
Brain and Behavior, Vol 13, Iss 2, Pp n/a-n/a (2023)
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain
Externí odkaz:
https://doaj.org/article/2ee981caa3584b2cabee05ffa1a8e5db
Autor:
null Philip Wing‐Lok Ho, null Lingfei Li, null Hui‐Fang Liu, null Zoe Yuen‐Kiu Choi, null Eunice Eun Seo Chang, null Shirley Yin‐Yu Pang, null Yasine Malki, null Chi‐Ting Leung, null Michelle Hiu‐Wai Kung, null David Boyer Ramsden, null Shu‐Leong Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea8f2b0aac0a3faff869235c11358e9d
https://doi.org/10.1002/brb3.2886/v2/response1
https://doi.org/10.1002/brb3.2886/v2/response1
Autor:
Hui-Fang Liu, Michelle Hiu-Wai Kung, Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Eunice Eun Seo Chang, Chi-Ting Leung, Zoe Yuen-Kiu Choi, David B. Ramsden, Shu-Leong Ho
Publikováno v:
Autophagy. 17:3196-3220
Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective mitochondria involves fission and ubiquitin-dependent degradation via mitop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86784a0cdfd18cbd8f168cfcabbf123
https://doi.org/10.1080/15548627.2020.1850008
https://doi.org/10.1080/15548627.2020.1850008
Autor:
Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3646
Synaptogyrin-3 (SYNGR3) is a synaptic vesicular membrane protein. Amongst four homologues (SYNGR1 to 4), SYNGR1 and 3 are especially abundant in the brain. SYNGR3 interacts with the dopamine transporter (DAT) to facilitate dopamine (DA) uptake and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6f04533313c563993560da27274b29
Autor:
Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational neurodegeneration. 11(1)
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarities between LRRK2-associated PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b062f3d5b5ec698cb3071cb593f21a8
https://pubmed.ncbi.nlm.nih.gov/35152914
https://pubmed.ncbi.nlm.nih.gov/35152914
Autor:
Huifang, Liu, Philip Wing-Lok, Ho, Chi-Ting, Leung, Shirley Yin-Yu, Pang, Eunice Eun Seo, Chang, Zoe Yuen-Kiu, Choi, Michelle Hiu-Wai, Kung, David Boyer, Ramsden, Shu-Leong, Ho
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective mitochondria involves fission and ubiquitin-dependent degradation via mitop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bba90b04e129d71df1e6a337fa00de46
https://pubmed.ncbi.nlm.nih.gov/33300446
https://pubmed.ncbi.nlm.nih.gov/33300446