Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney

Autor: Zoe McArdle, Michiel F. Schreuder, Karen M. Moritz, Kate M. Denton, Reetu R. Singh

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Children born with a solitary functioning kidney (SFK) have an increased risk of hypertension and kidney disease from early in adulthood. In response to a reduction in kidney mass, the remaining kidney undergoes compensatory kidney growth. This is as

Externí odkaz: https://doaj.org/article/8f51d01e3c074f7cad7ce3501059a715

Angiotensin II infusion enhances renal aminopeptidase expression in female but not male mice

Autor: Sarah Walton, Katrina Mirabito Colafella, Zoe McArdle, Cashveen Kaur, Han Xu, Kate Denton

Publikováno v: Physiology. 38

Sexual dimorphism in the intrarenal homeostasis of angiotensin (Ang) peptides may influence blood pressure control. Aminopeptidase A (APA) and aminopeptidase N (APN) catalyse the degradation of AngII and AngIII, respectively, but sex differences in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cde288501be89c5a41fd7e6a800310d9
https://doi.org/10.1152/physiol.2023.38.s1.5734748

Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age

Autor: Zoe McArdle, Reetu R. Singh, Helle Bielefeldt-Ohmann, Karen M. Moritz, Michiel F. Schreuder, Kate M. Denton

Publikováno v: Journal of the American Society of Nephrology, 33, 1341-1356
Journal of the American Society of Nephrology, 33, 7, pp. 1341-1356
J Am Soc Nephrol

Item does not contain fulltext BACKGROUND: Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70eb7aa5d28a0cc65c6141f7118f7ab
https://doi.org/10.1681/asn.2021111534

Blunted diuretic and natriuretic responses to acute sodium loading early after catheter-based renal denervation in normotensive sheep

Autor: Roberto B. Pontes, Lindsea C. Booth, Zoe McArdle, Yugeesh R Lankadeva, Markus P. Schlaich, Reetu R. Singh, Song T. Yao, Sally G Hood, Clive N. May

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 317:R319-R327

Catheter-based renal denervation (RDN) was introduced as a treatment for resistant hypertension. There remain critical questions regarding the physiological mechanisms underlying the hypotensive effects of catheter-based RDN. Previous studies indicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f1d504b7b40da6e33a170630e1d77b
https://doi.org/10.1152/ajpregu.00228.2018

Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease

Autor: Lindsea C. Booth, Clive N. May, Kate M. Denton, Zoe McArdle, Geoff Head, Karen M. Moritz, Markus P. Schlaich, Reetu R. Singh

Publikováno v: Hypertension (Dallas, Tex. : 1979). 77(4)

Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in hypertensive chronic kidney disease (CKD). In sheep with hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves kidney functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938fcda844654a2434ec8c835673e964
https://pubmed.ncbi.nlm.nih.gov/33641371