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Autor:
Mariateresa Fulciniti, Zoe Jacobson, Georg E. Winter, Michael A. Erb, Michael A. Lopez, Evon Poon, Donald R. Polaski, Thomas F. Westbrook, Jaime M. Reyes, James E. Bradner, Matthew A. Lawlor, Charles Y. Lin, Rachel A. Hirsch, Rhamy Zeid, Nikhil P. Munshi, Louis Chesler, Behnam Nabet, Kristen L. Karlin, Thomas G. Scott
Publikováno v:
Nature Genetics. 50:515-523
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogeni