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Akademický článek

Cerebrospinal fluid immune cells appear similar across neuropathic and non-neuropathic pain conditions [version 1; peer review: 2 approved]

Autor: Jon Lampa, Franziska Denk, Ramla Abuukar Abdullahi, Adnan Al-Kaisy, Jonathan Royds, Zoe Hore

Publikováno v: Wellcome Open Research, Vol 8 (2023)

Background Microglia have been implicated in the pathophysiology of neuropathic pain. Here, we sought to investigate whether cerebrospinal fluid (CSF) might be used as a proxy-measure of microglial activation in human participants. Methods We preform

Externí odkaz: https://doaj.org/article/b5d46889ba74449eab89e5c5d04067df

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Akademický článek

Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain

Autor: Jessica Saunders, Zoe Hore, Clive Gentry, Stephen McMahon, Franziska Denk

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Traditionally, neuroscience has had to rely on mixed tissue analysis to examine transcriptional and epigenetic changes in the context of nervous system function or pathology. However, particularly when studying chronic pain conditions, this approach

Externí odkaz: https://doaj.org/article/80c31bc919484425bdd7a90374e5908a

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Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatability

Autor: Sara Villa-Hernandez, Zoe Hore, Franziska Denk

Publikováno v: Wellcome Open Research

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of various chemotherapeutic agents, including oxaliplatin. It is highly prevalent amongst cancer patients, causing sensory abnormalities and pain. Unfortunately,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e371f96ea71530e1345c9e4436448e6c

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Changes in the transcriptional fingerprint of satellite glial cells following peripheral nerve injury

Autor: Stephen B. McMahon, Zoe Hore, Lone Tjener Pallesen, Sara E. Jager, Mette Richner, Franziska Denk, Peter Harley, Christian Bjerggaard Vaegter

Publikováno v: Jager, S E, Pallesen, L T, Richner, M, Harley, P, Hore, Z, McMahon, S, Denk, F & Vaegter, C B 2020, ' Changes in the transcriptional fingerprint of satellite glial cells following peripheral nerve injury ', Glia, vol. 68, no. 7, pp. 1375-1395 . https://doi.org/10.1002/glia.23785

Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of SGCs, contributing to, for example, neuropathic pain through modulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bb3434b3f105e002157a3924e8ee35
https://doi.org/10.1002/glia.23785

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Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice

Autor: Christer Hogstrand, Zoe Hore, Anne-Katrine Lundebye, Jason P. Lerch, Jacob Ellegood, Cathy Fernandes, Stuart Horswell, K. Peter Giese, Keiko Mizuno, Brigitta Stockinger, Conor Mohan, M. Albert Basson, Abhyuday K Swamy, Talia E Gileadi

Publikováno v: Environmental Health Perspectives

Background: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent and toxic environmental pollutant. Gestational exposure to TCDD has been linked to cognitive and motor deficits, and increased incidence of autism spectrum disorder (ASD) traits i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b2e30f7e44975d08aa6d0833376b3
https://doi.org/10.1289/ehp7352

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Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain

Autor: Zoe Hore, David C. Bulmer, Ewan St. John Smith, Sylvine Lalnunhlimi, Leonie S. Taams, Charity N. Bhebhe, Franziska Denk, Sampurna Chakrabarti, Luke A. Pattison, Gerard Callejo

Publikováno v: Pain

Supplemental Digital Content is Available in the Text. Fibroblast-like synoviocytes (FLS) interact with articular sensory nerve endings. Coculture of tumor necrosis factor (TNF-α)-stimulated FLS and knee-innervating sensory neurons reveals FLS-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf08cd7733632e2a8dfd160ca7b0f24a

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A transcriptional toolbox for exploring peripheral neuro-immune interactions

Autor: Monica Dahiya, Zoe Hore, Federico Uchenna Stanley, Sara E. Jager, Franziska Denk, Peter Harley, Zhi Liang, Aleksandra Michrowska, Sara Villa-Hernandez, Federica La Russa

Publikováno v: Pain
bioRxiv
Biorxiv

Correct communication between immune cells and peripheral neurons is crucial for the protection of our bodies. Its breakdown is observed in many common, often painful conditions, including arthritis, neuropathies and inflammatory bowel or bladder dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a976aca1f3f9c63dc62058903150414d
https://doi.org/10.1101/813980

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Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain

Autor: Zoe Hore, Franziska Denk, Gerard Callejo, Sylvine Lalnunhlimi, Sampurna Chakrabarti, Leonie S. Taams, David C. Bulmer, Luke A. Pattison, Ewan St. John Smith, Charity N. Bhebhe

Background Pain is a principle contributor to the global burden of arthritis with peripheral sensitization being a major cause of arthritis-related pain. Within the knee joint, distal endings of dorsal root ganglion neurons (knee neurons) interact wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b12620839b293043504caef4490899
https://doi.org/10.1101/791251

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Neuroimmune interactions in chronic pain - an interdisciplinary perspective

Autor: Zoe Hore, Franziska Denk

Publikováno v: Hore, Z & Denk, F 2019, ' Neuroimmune interactions in chronic pain-an interdisciplinary perspective ', Brain, Behavior, and Immunity, vol. 79, pp. 56-62 . https://doi.org/10.1016/j.bbi.2019.04.033

It is widely accepted that communication between the nervous and immune systems is involved in the development of chronic pain. At each level of the nervous system, immune cells have been reported to accompany and frequently mediate dysfunction of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe7ecf2edb5677047b4d46e5bfd6655
https://kclpure.kcl.ac.uk/ws/files/109599853/BBI_revision_for_proofs.pdf

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Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis

Autor: Jie Su, Zsuzsanna Wiesenfeld-Hallin, Jon Lampa, Camilla I. Svensson, Tianle Gao, Katalin Sandor, Johanna Estelius, Xiao-Jun Xu, Nilesh M. Agalave, Tomas Hökfelt, Teresa Fernandez-Zafra, Franziska Denk, Zoe Hore, Alexandra Jurczak

Publikováno v: Fernandez-Zafra, T, Gao, T, Jurczak, A, Sandor, K, Hore, Z, Agalave, N M, Su, J, Estelius, J, Lampa, J, Hokfelt, T, Wiesenfeld-Hallin, Z, Xu, X, Denk, F & Svensson, C I 2019, ' Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis ', Pain, vol. 160, no. 1, pp. 224-236 . https://doi.org/10.1097/j.pain.0000000000001394
PAIN

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used the collagen antibody-induced arthritis (CAIA) mouse model to examine diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74055b42331a1818883b666bc29cd0d2
https://kclpure.kcl.ac.uk/en/publications/86a700d4-eb22-4cd9-9eda-84f1568547b2

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