Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zoe Hewitt"'
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-10 (2020)
Abstract Background A major challenge for the clinical use of human pluripotent stem cells is the development of safe, robust and controlled differentiation protocols. Adaptation of research protocols using reagents designated as research-only to tho
Externí odkaz:
https://doaj.org/article/eb08e42d328843788d3981d70201b5d6
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Autor:
Loriana Vitillo, Fabiha Anjum, Zoe Hewitt, Dylan Stavish, Owen Laing, Duncan Baker, Ivana Barbaric, Pete Coffey
Publikováno v:
Stem Cell Reports. 18:782-797
Autor:
Oliver J. Bower, Zoe Hewitt, Peter W. Andrews, Sherif F. El-Khamisy, Paul J. Gokhale, Dylan Stavish, Jason A. Halliwell, Christopher J. Price, Thomas J. R. Frith, Owen Laing, Ivana Barbaric
Publikováno v:
Stem Cell Reports
Summary Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage d
Autor:
James O.S. Hackland, Antigoni Gogolou, Conor J. McCann, Alan J. Burns, Anestis Tsakiridis, Nikhil Thapar, Peter W. Andrews, Thomas J. R. Frith, Ivana Barbaric, Harry Moore, Zoe Hewitt
Publikováno v:
Stem Cell Reports, 15(3), 557-565. Cell Press
Stem Cell Reports
Stem Cell Reports
Summary The enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory multipotent cell population emerging from the dorsal neural tube between somites 1 and 7. Defects in the development and function of the ENS cause
Autor:
Glyn Stacey, Mark J.S. McCall, David J. Williams, Lise Morizur, Léa Lesueur, Michael M. Gepp, Heiko Zimmermann, Jennifer Man, Maryam Shariatzadeh, André Schulz, Amit Chandra, Olivier Chose, Orla O'Shea, Samantha L. Wilson, Julia C. Neubauer, Elsa Abranches, Zoe Hewitt
Publikováno v:
The International Journal, Advanced Manufacturing Technology
Establishing how to effectively manufacture cell therapies is an industry-level problem. Decentralised manufacturing is of increasing importance, and its challenges are recognised by healthcare regulators with deviations and comparability issues rece
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-10 (2020)
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-10 (2020)
Funder: Medical Research Council; doi: http://dx.doi.org/10.13039/501100000265
Funder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268
Funder: Engineering and Physical Sciences Research C
Funder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268
Funder: Engineering and Physical Sciences Research C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbc6fa0598305dec27fdebdfc2e53f3
https://eprints.whiterose.ac.uk/166180/1/s13287-020-01915-0.pdf
https://eprints.whiterose.ac.uk/166180/1/s13287-020-01915-0.pdf
Autor:
John Alexander, Ivana Barbaric, Zoe Hewitt, Sian Gregory, Wolf Reik, Peter W. Andrews, Richard Weightman, Harry Moore, Simon Andrews, Oliver Thompson, Serena Nik-Zainal, Andrew Wood, Felix Krueger, Kosuke Yusa, Paul J. Gokhale, Ferdinand von Meyenn, Marta Milo
Publikováno v:
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different culture conditions on the underlying mutation rate is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cfb1b92a9f0c24212fc9fb13395214
https://www.repository.cam.ac.uk/handle/1810/319113
https://www.repository.cam.ac.uk/handle/1810/319113
Autor:
Amit Chandra, Venkat Pisupati, Lynn Csontos, Jason A. Halliwell, Glyn Stacey, Mark J.S. McCall, Zoe Hewitt, Malin Parmar, Giulio Cossu, M Beatrice Panico, Ravenska Wagey, Harry Moore, Oliver Thompson, Peter W. Andrews, Valentin P. Shichkin, Thomas J. R. Frith, Ivana Barbaric, Francesco Tedesco, Alison Stacey, Charlotta Böiers
Publikováno v:
Stacey, G N, Andrews, P W, Barbaric, I, Boiers, C, Chandra, A, Cossu, G, Csontos, L, Frith, T J, Halliwell, J A, Hewitt, Z, McCall, M, Moore, H D, Parmar, M, Panico, M B, Pisupati, V, Shichkin, V P, Stacey, A R, Tedesco, F S, Thompson, O & Wagey, R 2019, ' Stem cell culture conditions and stability : A joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform ', Regenerative Medicine, vol. 14, no. 3, pp. 243-255 . https://doi.org/10.2217/rme-2019-0001
Regenerative medicine
Regenerative Medicine
Regenerative medicine
Regenerative Medicine
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eff64c36c3388d3bb4bde8756340e0
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
Autor:
Glyn Stacey, Nick Medcalf, Alison Wilson, Zoe Hewitt, Maurice A. Canham, Julian Braybrook, Damian Marshall, Louis Masi, Ivan Wall, Florence Bietrix, Ioannis Bantounas, Loriana Vitillio, Jonathan Campbell, Mathilde Girard, Anne L. Plant, Gabor Foldes, Yvonne Reinwald, Roger A. Barker, Mark J.S. McCall, Jamie A. Thurman-Newell, Nina Kotsopoulou, Ricardo Baptista, Ying Yang, Conor J. McCann, Rudy Gilmanshin, Johan Hyllner, Dave Thomas, Helen Jesson, Jacqueline Wolfrum, Harry Moore, Marc Turner, Nicholas F Blair, Julie Kerby, David Pan, Jacqueline Barry, Paul C. Hourd, Erwin Gorjup, Stanley Kowalski, Amit Chandra, Chris Leidel, Robert Thomas, David J. Williams, Heiko Zimmerman, Sujith Sebastian, Jasmin Kee, Malin Parmar, Hiroki Ozawa, J. Richard Archer, Peter R.T. Archibald
Publikováno v:
Regenerative Medicine
© 2016 Future Medicine Ltd.This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Com