Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Zoe E. Clayton"'
β3 Adrenergic Receptor Stimulation Promotes Reperfusion in Ischemic Limbs in a Murine Diabetic Model
Autor:
Kristen J. Bubb, Dhanya Ravindran, Siân P. Cartland, Meghan Finemore, Zoe E. Clayton, Michael Tsang, Owen Tang, Mary M. Kavurma, Sanjay Patel, Gemma A. Figtree
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Aims/Hypothesis: Peripheral arterial disease (PAD) is a major burden, resulting in limb claudication, repeated surgical interventions and amputation. There is an unmet need for improved medical management of PAD that improves quality of life, maintai
Externí odkaz:
https://doaj.org/article/082780fc32a24d84884dd859d5dd3f60
Autor:
Jack D. Hywood, Sara Sadeghipour, Zoe E. Clayton, Jun Yuan, Colleen Stubbs, Jack W. T. Wong, John P. Cooke, Sanjay Patel
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Induced endothelial cells (iECs) generated from neonatal fibroblasts via transdifferentiation have been shown to have pro-angiogenic properties and are a potential therapy for peripheral arterial disease (PAD). It is unknown if iECs can be generated
Externí odkaz:
https://doaj.org/article/968c8f3c7a684dcdbfd1764f40d6759d
Autor:
Richard P. Tan, Alex H. P. Chan, Katarina Lennartsson, Maria M. Miravet, Bob S. L. Lee, Jelena Rnjak-Kovacina, Zoe E. Clayton, John P. Cooke, Martin K. C. Ng, Sanjay Patel, Steven G. Wise
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Induced pluripotent stem-cell derived endothelial cells (iPSC-ECs) can be generated from any somatic cell and their iPSC sources possess unlimited self-renewal. Previous demonstration of their proangiogenic activity makes them a p
Externí odkaz:
https://doaj.org/article/df24d6d8f880470aa62ff642e710f57b
Publikováno v:
Journal of Obesity, Vol 2014 (2014)
The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades. As such, interest into the long term outcomes of consuming high levels of fruct
Externí odkaz:
https://doaj.org/article/0dc4804f759b47b18215d6ca45503bf9
Autor:
Robert D. Hume, Shaan Kanagalingam, Tejas Deshmukh, Siqi Chen, Suzanne M. Mithieux, Fairooj N. Rashid, Iman Roohani, Juntang Lu, Tram Doan, Dinny Graham, Zoe E. Clayton, Eugene Slaughter, Eddy Kizana, April S. Stempien-Otero, Paula Brown, Liza Thomas, Anthony S. Weiss, James J.H. Chong
Publikováno v:
Circulation Research. 132:72-86
Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticit
Autor:
Robert D, Hume, Shaan, Kanagalingam, Tejas, Deshmukh, Siqi, Chen, Suzanne M, Mithieux, Fairooj, Rashid, Iman, Roohani, Juntang, Lu, Tram, Doan, Dinny, Graham, Zoe E, Clayton, Eugene, Slaughter, Eddy, Kizana, April S, Stempien-Otero, Paula, Brown, Liza, Thomas, Anthony S, Weiss, James J H, Chong
Publikováno v:
Circulation research.
Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may ha
Autor:
Dinesh Selvakumar, Zoe E. Clayton, Andrew Prowse, Steve Dingwall, Jacob George, Haisam Shah, Siqi Chen, Robert D. Hume, Laurentius Tjahjadi, Sindhu Igoor, Rhys J.P. Skelton, Alfred Hing, Hugh Paterson, Sheryl L. Foster, Lachlan Pearson, Emma Wilkie, Prajith Jeyaprakash, Zhixuan Wu, Jeffrey R. McArthur, Tony Barry, Juntang Lu, Vu Tran, Richard Bennett, Yasuhito Kotake, Timothy Campbell, Samual Turnbull, Quan Nguyen, Guiyan Ni, Stuart M. Grieve, Nathan J. Palpant, Faraz Pathan, Eddy Kizana, Saurabh Kumar, Peter P. Gray, James J.H. Chong
BackgroundExciting pre-clinical data have confirmed that human pluripotent stem cell derived cardiomyocytes (PSC-CMs) can remuscularise the injured or diseased heart, with several clinical trials now in planning or recruitment stages worldwide. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a7f46d89844310efcbf9967fbd5495b
https://doi.org/10.1101/2022.09.15.500719
https://doi.org/10.1101/2022.09.15.500719
Autor:
Dhanya Ravindran, James J.H. Chong, Cindy Kok, Melad Farraha, Saurabh Kumar, Dinesh Selvakumar, Zoe E. Clayton, Eddy Kizana
Publikováno v:
Clinical Therapeutics. 42:1911-1922
Purpose In the last decade, interest in gene therapy as a therapeutic technology has increased, largely driven by an exciting yet modest number of successful applications for monogenic diseases. Setbacks in the use of gene therapy for cardiac disease
Publikováno v:
Clinical Therapeutics. 42:1857-1879
Purpose We review the history of cardiac cell therapy, highlighting lessons learned from initial adult stem cell (ASC) clinical trials. We present pluripotent stem cell–derived cardiomyocytes (PSC-CMs) as a leading candidate for robust regeneration
β3 Adrenergic Receptor Stimulation Promotes Reperfusion in Ischemic Limbs in a Murine Diabetic Model
Autor:
Owen Tang, Dhanya Ravindran, Meghan Finemore, Sanjay Patel, Mary M. Kavurma, Siân P. Cartland, Zoe E. Clayton, Gemma A. Figtree, Michael Tsang, Kristen J. Bubb
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Aims/Hypothesis: Peripheral arterial disease (PAD) is a major burden, resulting in limb claudication, repeated surgical interventions and amputation. There is an unmet need for improved medical management of PAD that improves quality of life, maintai