Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zoe C Johnston"'
Autor:
Franz S Gruber, Anthony Richardson, Zoe C Johnston, Rachel Myles, Neil R Norcross, David P Day, Irene Georgiou, Laura Sesma-Sanz, Caroline Wilson, Kevin D Read, Sarah Martins da Silva, Christopher L R Barratt, Ian H Gilbert, Jason R Swedlow
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297666 (2024)
Male contraceptive options and infertility treatments are limited, and almost all innovation has been limited to updates to medically assisted reproduction protocols and methods. To accelerate the development of drugs that can either improve or inhib
Externí odkaz:
https://doaj.org/article/f2f5d29a721e4ad38c065b5e3404a1c2
Publikováno v:
eLife, Vol 9 (2020)
There is an urgent need to develop new methods for male contraception, however a major barrier to drug discovery has been the lack of validated targets and the absence of an effective high-throughput phenotypic screening system. To address this defic
Externí odkaz:
https://doaj.org/article/ff8909f58458495680b57381786e13f9
Autor:
Peter J O'Shaughnessy, Jean Philippe Antignac, Bruno Le Bizec, Marie-Line Morvan, Konstantin Svechnikov, Olle Söder, Iuliia Savchuk, Ana Monteiro, Ugo Soffientini, Zoe C Johnston, Michelle Bellingham, Denise Hough, Natasha Walker, Panagiotis Filis, Paul A Fowler
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000002 (2019)
Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen
Externí odkaz:
https://doaj.org/article/4dcdf7a075af42d591b0e1daf4f6113a
Autor:
Franz S. Gruber, Anthony Richardson, Zoe C. Johnston, Rachel Myles, Neil Norcross, David Day, Irene Georgiou, Laura Sesma Sanz, Caroline Wilson, Kevin D. Read, Sarah Martins da Silva, Christopher L. R. Barratt, Ian H. Gilbert, Jason R. Swedlow
Male contraceptive options and infertility treatments are limited. To help overcome these limitations we established a small molecule library as a toolbox for assay development and screening campaigns using human spermatozoa. We have profiled all com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f8a71fa8e5a4846798fbbccf07f3af
https://doi.org/10.1101/2023.05.02.539126
https://doi.org/10.1101/2023.05.02.539126
Autor:
Zoe C Johnston, Franz S Gruber, Sean G Brown, Neil R Norcross, Jason Swedlow, Ian H Gilbert, Christopher L R Barratt
Publikováno v:
Reproduction. 163:R1-R9
Despite recent advances in male reproductive health research, there remain many elements of male infertility where our understanding is incomplete. Consequently, diagnostic tools and treatments for men with sperm dysfunction, other than medically ass
Autor:
Neil R. Norcross, Irene Georgiou, Zoe C. Johnston, Franz S. Gruber, Jason R. Swedlow, Kevin D. Read, Christopher LR. Barratt, Ian H. Gilbert
Publikováno v:
European journal of medicinal chemistry. 243
There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect.
Autor:
Jason R. Swedlow, I. Georgiou, Kevin D. Read, Franz S. Gruber, Christopher L.R. Barratt, S. Martins de Silva, Ian H. Gilbert, Neil R. Norcross, Caroline Wilson, Zoe C. Johnston
Publikováno v:
Human reproduction (Oxford, England). 37(3)
STUDY QUESTION Can a high-throughput screening (HTS) platform facilitate male fertility drug discovery? SUMMARY ANSWER An HTS platform identified a large number of compounds that enhanced sperm motility. WHAT IS KNOWN ALREADY Several efforts to find
Autor:
William A. Richardson, Zoe C. Johnston, Richard W.P. Smith, Ross C. Anderson, Barbara Gorgoni, Nicola K. Gray, Grieve Km
Aberrant gene expression during gametogenesis is one of the factors underlying infertility, which affects roughly 15% of couples worldwide.Deleted-in-Azoospermia-Like (DAZL),a member of theDAZ-genefamily, encodes an mRNA-specific regulator of transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c30a154e6dd2c7f8fc4ee4ffb42e3e
https://doi.org/10.1101/2021.02.02.429436
https://doi.org/10.1101/2021.02.02.429436
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
There is an urgent need to develop new methods for male contraception, however a major barrier to drug discovery has been the lack of validated targets and the absence of an effective high-throughput phenotypic screening system. To address this defic