Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Zoe, Waibler"'
Autor:
Martina Anzaghe, Marc A. Niles, Eugenia Korotkova, Monica Dominguez, Stefanie Kronhart, Samira Ortega Iannazzo, Ingo Bechmann, Malte Bachmann, Heiko Mühl, Georg Kochs, Zoe Waibler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Type I interferons (IFN) are pro-inflammatory cytokines which can also exert anti-inflammatory effects via the regulation of interleukin (IL)-1 family members. Several studies showed that interferon receptor (IFNAR)-deficient mice develop severe live
Externí odkaz:
https://doaj.org/article/1ddca19e91e5403ebf5404802d5f9fbd
Autor:
Eva Ringler, Samira Ortega Iannazzo, Jessica Herzig, Lisa M. Weiss, Martina Anzaghe, Lilija Miller, Zoe Waibler
Publikováno v:
Haematologica, Vol 108, Iss 6 (2023)
The most serious complication in the treatment of hemophilia A (HA) is the development of factor (F)VIII inhibitors or antidrug antibodies (ADA) occurring in 25-35% of patients with severe HA. The immunological mechanisms underlying the development o
Externí odkaz:
https://doaj.org/article/efed70b16353476c81b40cf301c28a75
Autor:
Steffi Krauter, Nicole Büscher, Eric Bräuchle, Samira Ortega Iannazzo, Inessa Penner, Nadine Krämer, Patricia Gogesch, Simone Thomas, Marina Kreutz, Mario Dejung, Anja Freiwald, Falk Butter, Zoe Waibler, Bodo Plachter
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1326 (2022)
Human cytomegalovirus (HCMV) infection is associated with severe disease conditions either following congenital transmission of the virus or viral reactivation in immunosuppressed individuals. Consequently, the establishment of a protective vaccine i
Externí odkaz:
https://doaj.org/article/6b6f8b31f9634f6887338cdd87f2d9e4
Autor:
Marc A. Niles, Patricia Gogesch, Stefanie Kronhart, Samira Ortega Iannazzo, Georg Kochs, Zoe Waibler, Martina Anzaghe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The exact role of innate immune cells upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their contribution to the formation of the corona virus-induced disease (COVID)-19 associated cytokine storm is not yet fully u
Externí odkaz:
https://doaj.org/article/f63d7aa6893349199e5e2e511cd772da
Autor:
Katharina Borst, Sven Flindt, Patrick Blank, Pia-Katharina Larsen, Chintan Chhatbar, Jennifer Skerra, Julia Spanier, Christoph Hirche, Martin König, Tomas Alanentalo, Martin Hafner, Zoe Waibler, Klaus Pfeffer, Veronika Sexl, Gerd Sutter, Werner Müller, Theresa Graalmann, Ulrich Kalinke
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008279 (2020)
IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced du
Externí odkaz:
https://doaj.org/article/5b7976512ad24a3da14b6b045aff5664
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8947 (2021)
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indicati
Externí odkaz:
https://doaj.org/article/7d60a0c09f1f411f85df0f2b24519f73
Autor:
Martina Anzaghe, Theresa Resch, Elea Schaser, Stefanie Kronhart, Clara Diez, Marc A. Niles, Eugenia Korotkova, Stefan Schülke, Sonja Wolfheimer, Dorothea Kreuz, Marion Wingerter, María Matilde Bartolomé Rodríguez, Zoe Waibler
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR−/−) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the s
Externí odkaz:
https://doaj.org/article/b643c4839cd14e8abf38257589ce4676
Autor:
Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne Schiffmann, Zoe Waibler, Vanessa Neuhaus, Susann Dehmel, Venkata Satagopam, Reinhard Schneider, Marek Ostaszewski, Wei Gu
We address the need for modelling and predicting adverse outcomes in immunotoxicology to improve non-clinical assessments of immunomodulatory therapy safety and efficacy. The integrated approach includes, first, the adverse outcome pathway concept es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a120503547f80780247e0a3025525e0a
https://doi.org/10.1101/2023.03.21.533620
https://doi.org/10.1101/2023.03.21.533620
Autor:
Katharina Arens, Christodoulos Filippis, Helen Kleinfelder, Arthur Goetzee, Gabriele Reichmann, Peter Crauwels, Zoe Waibler, Katrin Bagola, Ger van Zandbergen
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tumor necrosis factor α (TNFα) drives the pathophysiology of human autoimmune diseases and consequently, neutralizing antibodies (Abs) or Ab-derived molecules directed against TNFα are essential therapeutics. As treatment with several TNFα blocke
Externí odkaz:
https://doaj.org/article/1c997a83871d44a2a84c17ca702b1e32
Autor:
Christodoulos Filippis, Katharina Arens, Gaetan Aime Noubissi Nzeteu, Gabriele Reichmann, Zoe Waibler, Peter Crauwels, Ger van Zandbergen
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-liga
Externí odkaz:
https://doaj.org/article/891f46a9083d44d3b116cdacf14c34e3