Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Zoanthenol"'
The enantioselective synthesis of both caprolactam and enone synthons for the DEFG ring system of zoanthenol are described. The evolution of this synthetic approach proceeds first through a synthesis using the chiral pool as a starting point. Challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43bda61eb73938eb1cf86fea45cb4e3
https://resolver.caltech.edu/CaltechAUTHORS:20160425-132914132
https://resolver.caltech.edu/CaltechAUTHORS:20160425-132914132
Autor:
Naoki Sugano, Masahiro Hirama, Shuji Yamashita, Shoji Kobayashi, Yuuki Koizumi, Go Hirai, Hiroki Oguri
Publikováno v:
Chemistry - An Asian Journal. 3:1549-1557
Zoanthenol, isolated from Zoanthus sp., possesses an extremely complex architecture including contiguous quaternary carbons. An enantioselective synthesis of the fully functionalized ABC-ring of zoanthenol has been achieved and is described herein. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d1a198a25cbfe96a5d25a5bafc2452
https://doi.org/10.1002/asia.200800079
https://doi.org/10.1002/asia.200800079
Publikováno v:
Angewandte Chemie International Edition. 46:4077-4080
A smokin' hot cyclization! When the racemic cyclization precursor is heated in neat trifluoroacetic acid, an unusual Friedel–Crafts-type cyclization forms the carbocyclic core of the marine alkaloid zoanthenol containing two all-carbon-substituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdca06480e33f71d094328207297e826
https://doi.org/10.1002/anie.200700430
https://doi.org/10.1002/anie.200700430
Publikováno v:
Tetrahedron Letters. 54:1389-1391
Zoanthenol, isolated from Zoanthus sp., possesses an extremely complex architecture including congested quaternary carbons. We describe a concise synthesis of the fully functionalized ABC-ring of zoanthenol based on sequential radical reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91b74d32116a06e079ade1dc3b1ec20c
https://doi.org/10.1016/j.tetlet.2012.12.104
https://doi.org/10.1016/j.tetlet.2012.12.104
Autor:
Masahiko Hayashi, Go Hirai, Koji Koyama, Masahiro Hirama, Yuuki Koizumi, Sameh M. Moharram, Hiroki Oguri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2647-2651
Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. While the structure of zoanthamines, especially the ABC-ring portion, is similar to that of steroids, the CDEFG-ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e005101ea8344a623a0264ebdf6727ad
https://doi.org/10.1016/j.bmcl.2004.02.064
https://doi.org/10.1016/j.bmcl.2004.02.064
Publikováno v:
Tetrahedron Letters. 42:5783-5787
The highly congested ABC-ring moiety of zoanthenol was stereoselectively synthesized via an alkoxylithium-mediated coupling between the A-ring and C-ring moieties followed by a Mizoroki–Heck-type ring closure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d50e9ad917dafb7cc994c0fdf03d9fc
https://doi.org/10.1016/s0040-4039(01)01110-8
https://doi.org/10.1016/s0040-4039(01)01110-8
Publikováno v:
Tetrahedron Letters. 50:3182-3184
An unusual loss of CO was observed during a key cyclization event in efforts toward the total synthesis of zoanthenol. The synthesis of the cyclization precursor and a proposed mechanism for decarbonylation are detailed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba0e23251b4bf806bb6a96075950968
https://doi.org/10.1016/j.tetlet.2009.01.121
https://doi.org/10.1016/j.tetlet.2009.01.121
Autor:
Douglass F. Taber
Publikováno v:
Organic Synthesis
Yuqing Hou of Southern Illinois University found (J. Org. Chem. 2009, 74, 6362) that the peroxy ether 2 served effectively to directly transfer a methoxy group to the lithiated 1 to give 3. Wanzhi Chen of Zhejiang University, Xixi Campus, showed (J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67629191e63a187f0609866fe4b4d0ba
https://doi.org/10.1093/oso/9780199965724.003.0061
https://doi.org/10.1093/oso/9780199965724.003.0061
Publikováno v:
Accounts of chemical research. 45(5)
Zoanthamine alkaloids, isolated from organisms in the Zoanthus genus, constitute a distinctive family of marine metabolites. These molecules exhibit a broad spectrum of unique biological properties. For example, norzoanthamine inhibits interleukin-6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1390a5a176f413b13b14465750a12634
https://pubmed.ncbi.nlm.nih.gov/22340011
https://pubmed.ncbi.nlm.nih.gov/22340011
Publikováno v:
ChemInform. 42
The total synthesis of zoanthenol, a unique aromatic member of the zoanthamine alkaloids, which has exhibited potent anti-platelet activities on human platelet aggregation, is described in full detail. The key step involves a Bronsted acid-promoted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c86a9556888274e7302cdb52488f4b01
https://doi.org/10.1002/chin.201123192
https://doi.org/10.1002/chin.201123192