Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

Autor: Amani Al-Adsani, Zoë D Burke, Daniel Eberhard, Katherine L Lawrence, Chia-Ning Shen, Anil K Rustgi, Hiroshi Sakaue, J Mark Farrant, David Tosh

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13650 (2010)

BACKGROUND:The pancreatic exocrine cell line AR42J-B13 can be reprogrammed to hepatocytes following treatment with dexamethasone. The question arises whether dexamethasone also has the capacity to induce ductal cells as well as hepatocytes. METHODOLO

Externí odkaz: https://doaj.org/article/a55eafc87a9d4e559fa6a81e0da14da7

Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway

Autor: Alan Richard Clarke, Karen Ruth Reed, Sheng Wen Yeh, David Tosh, Owen J. Sansom, Zoë D. Burke, Valerie Meniel

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-3 (2020)
Scientific Reports

While the Wnt/β-catenin pathway plays a critical role in the maintenance of the zonation of ammonia metabolizing enzymes in the adult liver, the mechanisms responsible for inducing zonation in the embryo are not well understood. Herein we address th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d532362b576c453114ae9c73e016e3
http://link.springer.com/article/10.1038/s41598-020-68277-8

The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal

Autor: Zoë D. Burke, Carmen Grimaldos Rodriguez, Stephen D. Weston, Sebastian L. Wild, David Tosh, Aya Elghajiji

Publikováno v: Genes
Genes, Vol 11, Iss 1163, p 1163 (2020)

The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The Wnt/β-catenin signalling pathway is vital for correct b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab8b52c2a5f5081a8ddfa96cdbbb429
https://doi.org/10.3390/genes11101163

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium

Autor: Jonathan M. Quinlan, Zoë D. Burke, Yu Chen, Ramiro Jover, Leonard P. Griffiths, David Tosh, Stephen G. Ward, J. Mark Farrant, M Bock, Jonathan M.W. Slack, Leigh Biddlestone, Wei-Yuan Yu, Benjamin J. Colleypriest

Publikováno v: Colleypriest, Benjamin J. Burke, Zoë D. Griffiths, Leonard P. Chen, Yu Yu, Wei-Yuan Jover Atienza, Ramiro Bock, Michael Biddlestone, Leigh Quinlan, Jonathan M. Ward, Stephen G. Mark Farrant, J. Slack, Jonathan M.W. Tosh, David 2017 Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium Differentiation 93 39 49
Differentiation; Research in Biological Diversity
Colleypriest, B J, Burke, Z D, Griffiths, L P, Chen, Y, Yu, W-Y, Jover, R, Bock, M, Biddlestone, L, Quinlan, J M, Ward, S G, Mark Farrant, J, Slack, J M W & Tosh, D 2017, ' Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium ', Differentiation, vol. 93, pp. 39-49 . https://doi.org/10.1016/j.diff.2016.11.001
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2cc347bafc05938c5ff5513913ddcb
http://hdl.handle.net/10550/65810

Ontogenesis of Hepatic and Pancreatic Stem Cells

Autor: Zoë D. Burke, David Tosh

Publikováno v: Stem Cell Reviews and Reports. 8:586-596

In the embryo, the liver and pancreas exhibit a close developmental relationship. Both tissues arise from neighbouring regions of the developing endoderm. As well as this close developmental relationship, the liver and pancreas can, under certain cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef616de1c824ff53cbcee88f69d2a0b
https://doi.org/10.1007/s12015-012-9350-2