Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zoë A. Hughes-Thomas"'
Publikováno v:
Angewandte Chemie International Edition. 42:4475-4478
Autor:
Zoryana Oliynyk, Zoë A. Hughes-Thomas, Yuliya Demydchuk, Christopher J. Wilkinson, Christian B. W. Stark, Peter F. Leadlay, Michelle A. Jones, Markiyan Oliynyk, Apoorva Bhatt, James Staunton
Publikováno v:
Molecular Microbiology. 49:1179-1190
The analysis of a candidate biosynthetic gene cluster (97 kbp) for the polyether ionophore monensin from Streptomyces cinnamonensis has revealed a modular polyketide synthase composed of eight separate multienzyme subunits housing a total of 12 exten
Autor:
Zoë A. Hughes-Thomas, Michelle A. Jones, Hui Hong, Peter F. Leadlay, Victor M. Bolanos-Garcia, Michelle L. Heathcote, Barbara M. Harvey, Rebecca M. Goss, Jonathan B. Spencer, Wolfgang Kroutil, James Staunton
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(9)
Polyether ionophores, such as monensin A, are known to be biosynthesised, like many other antibiotic polyketides, on giant modular polyketide synthases (PKSs), but the intermediates and enzymes involved in the subsequent steps of oxidative cyclisatio
Autor:
Markiyan, Oliynyk, Christian B W, Stark, Apoorva, Bhatt, Michelle A, Jones, Zoë A, Hughes-Thomas, Christopher, Wilkinson, Zoryana, Oliynyk, Yuliya, Demydchuk, James, Staunton, Peter F, Leadlay
Publikováno v:
Molecular microbiology. 49(5)
The analysis of a candidate biosynthetic gene cluster (97 kbp) for the polyether ionophore monensin from Streptomyces cinnamonensis has revealed a modular polyketide synthase composed of eight separate multienzyme subunits housing a total of 12 exten
Autor:
Christopher J, Wilkinson, Zoë A, Hughes-Thomas, Christine J, Martin, Ines, Böhm, Tatiana, Mironenko, Matthew, Deacon, Michael, Wheatcroft, Gabriele, Wirtz, James, Staunton, Peter F, Leadlay
Publikováno v:
Journal of molecular microbiology and biotechnology. 4(4)
An Escherichia coli-actinomycete shuttle vector, pCJW93, was constructed which places cloned genes under the control of the thiostrepton-inducible tip promoter from Streptomyces lividans. We also constructed expression vectors bearing the actII-ORF4/
Autor:
Michelle A. Jones, J. Staunton, H. A. I. Mcarthur, Christian B. W. Stark, Elizabeth J. Frost, J. B. Lester, Jesus Cortes, Christopher J. Wilkinson, Ellen L. McCormick, Peter F. Leadlay, Christian Bisang, Steven G. Kendrew, Zoë A. Hughes-Thomas, Markiyan Oliynyk, Z. Oliynyk, Paul F. Long
Publikováno v:
Journal of industrial microbiologybiotechnology. 27(6)
The biosynthesis of complex reduced polyketides is catalysed in actinomycetes by large multifunctional enzymes, the modular Type I polyketide synthases (PKSs). Most of our current knowledge of such systems stems from the study of a restricted number
Autor:
Barbara M. Harvey, Hui Hong, Michelle A. Jones, Zoë A. Hughes-Thomas, Rebecca M. Goss, Michelle L. Heathcote, Victor M. Bolanos-Garcia, Wolfgang Kroutil, James Staunton, Peter F. Leadlay, Jonathan B. Spencer
Publikováno v:
ChemBioChem; Sep2006, Vol. 7 Issue 9, p1435-1442, 8p