Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zoë, Bichler"'
The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD
Autor:
Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee, Wei Ren Tan, Christopher Ball, Norliza Binte Esmail Sahib, Ser Sue Ng, Jing Qu, Yingzi Liu, Haiyu Hong, Chaonong Cai, Nandini Chilagondanahalli Lakshmi Rao, Aileen Wee, Mark Dhinesh Muthiah, Zoë Bichler, Barbara Mickelson, Mei Suen Kong, Vanessa Shiyun Tay, Zhuang Yan, Jiapeng Chen, Aik Seng Ng, Yun Sheng Yip, Marcus Ivan Gerard Vos, Nicole Ashley Tan, Dao Liang Lim, Debbie Xiu En Lim, Manesh Chittezhath, Jadegoud Yaligar, Sanjay Kumar Verma, Harish Poptani, Xue Li Guan, Sambasivam Sendhil Velan, Yusuf Ali, Liang Li, Nguan Soon Tan, Walter Wahli
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic the huma
Externí odkaz:
https://doaj.org/article/516eada6ebe94695a2023966be28ab43
Autor:
Shan Zhang, Yabo Guo, Gio Fidelito, David R.L. Robinson, Chao Liang, Radiance Lim, Zoë Bichler, Ruiyang Guo, Gaoqi Wu, He Xu, Quan D. Zhou, Brijesh K. Singh, Paul Yen, Dennis Kappei, David A. Stroud, Lena Ho
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107558- (2023)
Summary: LINC00116 encodes a microprotein first identified as Mitoregulin (MTLN), where it was reported to localize to the inner membrane of mitochondria to regulate fatty acid oxidation and oxidative phosphorylation. These initial discoveries were f
Externí odkaz:
https://doaj.org/article/b76d12dc105f40af9b3523b6c63545e2
Autor:
Brenda L. Kick, Laura Anderson, Rosalinda Doty, Christine Wooley, Meaghan Dyer, Torrian Green, Veronica Knickerbocker, Zoe Brown, Samantha Loeber, Janine Wotton, Bonnie Lyons, Linda Waterman, Zoë Bichler
Publikováno v:
PLoS ONE, Vol 18, Iss 6 (2023)
Tarsal joint abnormalities have been observed in aged male mice on a C57BL background. This joint disease consists of calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, that can progress to ankylosis of the jo
Externí odkaz:
https://doaj.org/article/b98f262731b94087a02958c3101ab806
Autor:
Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee, Wei Ren Tan, Christopher Ball, Norliza Binte Esmail Sahib, Ser Sue Ng, Jing Qu, Yingzi Liu, Haiyu Hong, Chaonong Cai, Nandini C. L. Rao, Aileen Wee, Mark D. Muthiah, Zoë Bichler, Barbara Mickelson, Jia Qi Lee, Mei Suen Kong, Vanessa S.Y. Tay, Zhuang Yan, Jiapeng Chen, Aik Seng Ng, Yun Sheng Yip, Marcus Ivan Gerard Vos, Debbie Xiu En Lim, Manesh Chittezhath, Jadegoud Yaligar, Sanjay Kumar Verma, Harish Poptani, Xue Li Guan, S. Sendhil Velan, Yusuf Ali, Liang Li, Nguan Soon Tan, Walter Wahli
Adaptive T-cell immune response is essential in conferring protective immunity, a process requiring tight cellular homeostasis regulation. Pathological intrahepatic T-cell landscape has a role in NAFLD propagation; however, its activation remains unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa97f1db42b4fa5bd0adf6381fb62d1
https://doi.org/10.1101/2023.01.10.523354
https://doi.org/10.1101/2023.01.10.523354
Autor:
Rachel Ettinger, David V. Serreze, Torrian Green, Zoë Bichler, Timothy J. Hines, Jeremy J. Racine, Brynn M Cairns, Laura C. Anderson, Abigail L. D. Tadenev, Rosalinda Doty, Jacqueline K. White, Robert W. Burgess, Janine M Wotton, Harold D. Chapman, Meaghan E Dyer
Publikováno v:
The Journal of Immunology. 205:2026-2038
It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D) pathogenesis. In fact, a large proportion of islet-infiltrating B lymphocytes in the NOD mouse model of T1D p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d44dae5665038de45fb2886f2889b2ce
https://doi.org/10.4049/jimmunol.2000114
https://doi.org/10.4049/jimmunol.2000114
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70249 (2013)
Non-motor symptoms are increasingly recognized as important features of Parkinson's disease (PD). LRRK2 mutations are common causes of familial and sporadic PD. Non-motor features have not been yet comprehensively evaluated in LRRK2 transgenic mouse
Externí odkaz:
https://doaj.org/article/22251c2d9bc94b3292e9182211e357f2
Autor:
Jeremy J, Racine, Harold D, Chapman, Rosalinda, Doty, Brynn M, Cairns, Timothy J, Hines, Abigail L D, Tadenev, Laura C, Anderson, Torrian, Green, Meaghan E, Dyer, Janine M, Wotton, Zoë, Bichler, Jacqueline K, White, Rachel, Ettinger, Robert W, Burgess, David V, Serreze
Publikováno v:
J Immunol
It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D(4)) pathogenesis. In fact, a large proportion of islet-infiltrating B-lymphocytes in the NOD mouse model of T1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26a7f3116c975029d5c50a6907962edc
https://pubmed.ncbi.nlm.nih.gov/32938729
https://pubmed.ncbi.nlm.nih.gov/32938729
Autor:
Qiang Yuan, Olga Pletnikova, Paul F. Worley, H. Shawn Je, Nilofer Husain, Dong Qianying Sally, Yi Chun Yen, Zoë Bichler
Publikováno v:
Aging Cell
Summary Multiple loss‐of‐function mutations in TRIAD3 (a.k.a. RNF216) have recently been identified in patients suffering from Gordon Holmes syndrome (GHS), characterized by cognitive decline, dementia, and movement disorders. TRIAD3A is an E3 ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6f514eda412d5d4dfda0c902d5f22e
https://pubmed.ncbi.nlm.nih.gov/27995769
https://pubmed.ncbi.nlm.nih.gov/27995769
Autor:
Benjamin Chew, Zoë Bichler, Ananya Dasgupta, Sin Hui Neo, Dongliang Ma, Teclise Ng, Jae Ryun Ryu, Jing Zhao, Zhong Zhong, Eyleen L. K. Goh, Sreedharan Sajikumar
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 9 (2015)
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience
Attempts have been made to use glycogen synthase kinase-3 beta (GSK3β) inhibitors for prophylactic treatment of neurocognitive conditions. However the use of lithium, a non-specific inhibitor of GSK3β results in mild cognitive impairment in humans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dff62fe7218869895adc0f614ccd5ca
https://doi.org/10.3389/fnbeh.2015.00158
https://doi.org/10.3389/fnbeh.2015.00158
Autor:
Panagiotis S. Athanasopoulos, Christian Herrmann, Sebastian Neumann, Miriam Kutsch, Wright Jacob, Zoë Bichler, Dirk Wolters, Rolf Heumann, Eng-King Tan
Publikováno v:
Biological chemistry. 397(6)
Mutations in the gene coding for the multi-domain protein leucine-rich repeat kinase 2 (LRRK2) are the leading cause of genetically inherited Parkinson’s disease (PD). Two of the common found mutations are the R1441C and G2019S. In this study we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b084ff055f9720fdcadd827ee7888f1
https://pubmed.ncbi.nlm.nih.gov/26894577
https://pubmed.ncbi.nlm.nih.gov/26894577