Výsledky vyhledávání - "Zlatko, Janeba"

Akademický článek

Efficient Synthesis of α-Branched Purine-Based Acyclic Nucleosides: Scopes and Limitations of the Method

Autor: Jan Frydrych, Lenka Poštová Slavětínská, Martin Dračínský, Zlatko Janeba

Publikováno v: Molecules, Vol 25, Iss 18, p 4307 (2020)

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (prefer

Externí odkaz: https://doaj.org/article/e8e0e4d59e914ce6bf0a9bf5fae41ac1

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Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E 2 Production: Increasing Aqueous Solubility

Autor: Zdeněk Zídek, Filip Kalčic, Zlatko Janeba, Viktor Kolman

Publikováno v: ChemMedChem. 16:2802-2806

Water solubility is one of the key features of potential therapeutic agents. In order to enhance the low water solubility of the parent 5-butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine, a potent inhibitor of prostaglandin E2 (PGE2 ) production,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c937ad1b45a8bdd7447fbfaef5d4c9cf
https://doi.org/10.1002/cmdc.202100263

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Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)

Autor: Gabriel Birkus, Miroslav Smola, Petra Břehová, Lubomír Rulíšek, Martin Maxmilian Kaiser, Michal Šála, Aleš Marek, Martin Dračínský, Andrea Brázdová, Barbora Novotna, Zlatko Janeba, Milan Dejmek, Joshua R. Smith, Markéta Pimková Polidarová, Radim Nencka, Ondřej Páv, Evzen Boura, Ondrej Gutten

Publikováno v: Journal of Medicinal Chemistry. 64:7596-7616

Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the activity of 3',3'-c-di(2'F,2'dAMP) and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c7c8621ad313e02166230b7d6d0b2
https://doi.org/10.1021/acs.jmedchem.1c00301

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Akademický článek

Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E2 Production

Autor: Zdeněk Zídek, Viktor Kolman, Ondřej Baszczyňski, Filip Kalčic, Daniel Board, Zlatko Janeba

Publikováno v: Proceedings, Vol 22, Iss 1, p 24 (2019)

The pyrimidine heterocycle represents an elemental structural motif of numerous drugs. [...]

Externí odkaz: https://doaj.org/article/a32931bd495c4f3d84c6fa1adcfaba24

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Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase

Autor: Karolína Vaňková, Eva Doleželová, Eva Tloušťová, Dana Hocková, Alena Zíková, Zlatko Janeba

Publikováno v: European journal of medicinal chemistry. 239

A series of novel 7-aryl-7-deazaadenine-based N-branched acyclic nucleoside phosphonates (aza-ANPs) has been prepared using the optimized Suzuki cross-coupling reaction as the key synthetic step. The final free phosphonates 15a-h were inactive, due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa99a56cdd46f1de74a47841d33d0aa1
https://pubmed.ncbi.nlm.nih.gov/35763869

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