Zobrazeno 1 - 10
of 637
pro vyhledávání: '"Zlatanou A"'
Autor:
Agathanggelou, Angelo, Smith, Edward *, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey, Kearns, Pamela, Skowronska, Anna, Yates, Elliot, Parry, Helen, Hillmen, Peter, Reverdy, Celine, Delansorne, Remi, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Taylor, A.Malcolm R., Stewart, Grant S., Stankovic, Tatjana
Publikováno v:
In Blood 13 July 2017 130(2):156-166
Autor:
Thomas, A., Perry, T., Berhane, S., Oldreive, C., Zlatanou, A., Williams, L.R., Weston, V.J., Stankovic, T., Kearns, P., Pors, Klaus, Grand, R.J., Stewart, G.S.
Yes
Topoisomerase inhibitors are in common use as chemotherapeutic agents although they can display reduced efficacy in chemotherapy-resistant tumours, which have inactivated DNA damage response (DDR) genes, such as ATM and TP53. Here, we charac
Topoisomerase inhibitors are in common use as chemotherapeutic agents although they can display reduced efficacy in chemotherapy-resistant tumours, which have inactivated DNA damage response (DDR) genes, such as ATM and TP53. Here, we charac
Externí odkaz:
http://hdl.handle.net/10454/9412
Publikováno v:
Genes, Vol 8, Iss 2, p 64 (2017)
Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered
Externí odkaz:
https://doaj.org/article/517c44c0ec8942138e56a7882da3aa02
Autor:
Lynn Greenhalgh, Janine Altmüller, Bernd Wollnik, Gökhan Yigit, Michael B. Bober, Sarah McGlasson, Andrew N. Blackford, Louise S. Bicknell, Matthew E. Hurles, Holger Thiele, Peter Nürnberg, Carol Anne Martin, Karen J. Mackenzie, Kaalak Reddy, Andrea Leitch, Grant S. Stewart, Margaret E. Harley, Luciana Chessa, Adeline Fluteau, Stephen P. Jackson, Martin R. Higgs, Olga Murina, Mihail Halachev, Martin A M Reijns, Simone Sabbioneda, Mahmoud Salim, Anastasia Zlatanou, Nursel Elcioglu, Andrew P. Jackson, Mohamad Maghnie
Publikováno v:
Nature genetics
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycleprogression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitinligase, in patients with microcephalic primordial dwarfism/S
Autor:
Satoshi Tateishi, Igor B. Rogozin, Yang Yang, Vyacheslav Yurchenko, Anastasia Zlatanou, Yanzhe Gao, Cyrus Vaziri
Publikováno v:
Cell Cycle
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the ‘Y-family’ Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA repl
DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress
Autor:
Weimin Ding, Cyrus Vaziri, Anastasia Zlatanou, Yuki Tanoue, Satoshi Tateishi, Yang Yang, Michael Durando, Yanzhe Gao, Liz Mutter-Rottmayer, David W. Wyatt, Dale A. Ramsden
Publikováno v:
The Journal of Cell Biology
The elevated CDK2 activity of oncogene-expressing cells induces DNA replication stress. Yang et al. show that the DNA repair protein RAD18 facilitates damage-tolerant DNA synthesis via the DNA polymerase κ in cells with aberrantly high CDK2 activity
Autor:
Hessa S. Alsaif, Natalie J. Prescott, Dimitrios K. Papadopoulos, Martin R. Higgs, Sarah R. Wessel, Alex von Kriegsheim, David Cortez, Saleem Ahmed, Clare V. Logan, Andrea Leitch, Paula Carroll, B D Henderson, Olga Murina, Jumana Y. Al-Aama, Rachel M A Mottram, Janine Altmüller, Maha Alnemer, Peter Nürnberg, Audrey Vernet, Anastasia Zlatanou, Eissa Faqeih, John J. Reynolds, Louise S. Bicknell, Jennie E. Murray, Angela L. Duker, Ariella Amar, Sateesh Maddirevula, Alexander Brean, Luigina Spaccini, Mohammed Zain Seidahmed, Helen Cox, Mohammed Al Balwi, Carol Wise, Angela Peron, Kassiani Skouloudaki, Rachel C. Challis, Emma Hobson, Fowzan S. Alkuraya, Michael B. Bober, Abdulrahman Alswaid, Grant S. Stewart, Michael A. Simpson, E. Ferda Percin, Angela F. Brady, Hannah Bye, Raoul Heller, Gökhan Yigit, Žygimantė Tarnauskaitė, Grace Yoon, Christopher G. Mathew, Pavel Tomancak, Martin A M Reijns, Agaadir Almoisheer, Ranad Shaheen, Saeed Al Tala, Andrew P. Jackson, Alan J. Quigley, Yun Li, A. Malcolm R. Taylor, Rita Fischetto, Luciana Chessa, Seema Thakur
Publikováno v:
Reynolds, J, Bicknell, L S, Carroll, P, Higgs, M R, Shaheen, R, Murray, J E, Papadopoulos, D K, Leitch, A, Murina, O, Tarnauskaite, Z, Wessel, S R, Zlatanou, A, Vernet, A, von Kriegsheim, A, Mottram, R M A, Logan, C V, Bye, H, Li, Y, Brean, A, Maddirevula, S, Challis, R C, Skouloudaki, K, Almoisheer, A, Alsaif, H S, Amar, A, Prescott, N J, Bober, M, Duker, A, Faqeih, E, Seidahmed, M Z, Tala, S A, Alswaid, A, Ahmed, S, Al-Aama, J Y, Altmuller, J, Al Balwi, M, Brady, A F, Chessa, L, Cox, H, Fischetto, R, Heller, R, Henderson, B D, Hobson, E, Nurnberg, P, Percin, E F, Peron, A, Spaccini, L, Quigley, A J, Thakur, S, Wise, C A, Yoon, G, Alnemer, M, Yigit, G, Taylor, A M R, Reijns, M A M, Simpson, M A, Cortez, D, Alkuraya, F S, Mathew, C G, Jackson, A P & Stewart, G S 2017, ' Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism ', Nature Genetics, vol. 49, no. 4, pp. 537–549 . https://doi.org/10.1038/ng.3790
To ensure efficient genome duplication, cells have evolved numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify downstream neighbor of SON (DONSON) as a novel fork protection factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46628f8b75da700e872119db9b156d27
https://europepmc.org/articles/PMC5450907/
https://europepmc.org/articles/PMC5450907/
Autor:
Claire Breslin, Zhihong Zeng, Victoria Coulthard, Anastasia Zlatanou, Stuart L. Rulten, Keith W. Caldecott
Publikováno v:
DNA repair. 58
Acylpeptide hydrolase (APEH) deacetylates N-alpha-acetylated peptides and selectively degrades oxidised proteins, but the biochemical pathways that are regulated by this protease are unknown. Here, we identify APEH as a component of the cellular resp
Publikováno v:
Genes, Vol 8, Iss 2, p 64 (2017)
Genes
Genes
Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered
Autor:
Tracey Perry, Elliot J. Yates, Guy Pratt, Céline Reverdy, Sina Yadollahi, Pamela Kearns, Peter Hillmen, Tatjana Stankovic, Remi Delansorne, A. Malcolm R. Taylor, Paul Moss, Jingwen Mao, Anastasia Zlatanou, David Da Costa, Ceri E. Oldreive, Marwan Kwok, Nicholas J. Davies, Angelo Agathanggelou, Anna Skowronska, Helen Parry, Edward Smith, Shankara Paneesha, Grant S. Stewart
Publikováno v:
Blood. 130(2)
The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established. Whereas previous studies have mostly focused on the mechanisms underlying how USP7 directly