USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Autor: Agathanggelou, Angelo, Smith, Edward ^*, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey, Kearns, Pamela, Skowronska, Anna, Yates, Elliot, Parry, Helen, Hillmen, Peter, Reverdy, Celine, Delansorne, Remi, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Taylor, A.Malcolm R., Stewart, Grant S., Stankovic, Tatjana

Publikováno v: In Blood 13 July 2017 130(2):156-166

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53

Autor: Thomas, A., Perry, T., Berhane, S., Oldreive, C., Zlatanou, A., Williams, L.R., Weston, V.J., Stankovic, T., Kearns, P., Pors, Klaus, Grand, R.J., Stewart, G.S.

Yes
Topoisomerase inhibitors are in common use as chemotherapeutic agents although they can display reduced efficacy in chemotherapy-resistant tumours, which have inactivated DNA damage response (DDR) genes, such as ATM and TP53. Here, we charac

Externí odkaz: http://hdl.handle.net/10454/9412

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Autor: Lynn Greenhalgh, Janine Altmüller, Bernd Wollnik, Gökhan Yigit, Michael B. Bober, Sarah McGlasson, Andrew N. Blackford, Louise S. Bicknell, Matthew E. Hurles, Holger Thiele, Peter Nürnberg, Carol Anne Martin, Karen J. Mackenzie, Kaalak Reddy, Andrea Leitch, Grant S. Stewart, Margaret E. Harley, Luciana Chessa, Adeline Fluteau, Stephen P. Jackson, Martin R. Higgs, Olga Murina, Mihail Halachev, Martin A M Reijns, Simone Sabbioneda, Mahmoud Salim, Anastasia Zlatanou, Nursel Elcioglu, Andrew P. Jackson, Mohamad Maghnie

Publikováno v: Nature genetics
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451

DNA lesions encountered by replicative polymerases threaten genome stability and cell cycleprogression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitinligase, in patients with microcephalic primordial dwarfism/S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cde41bd5505ee27973df43b1ce1a0d
https://doi.org/10.1038/ng.3451

DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

Autor: Weimin Ding, Cyrus Vaziri, Anastasia Zlatanou, Yuki Tanoue, Satoshi Tateishi, Yang Yang, Michael Durando, Yanzhe Gao, Liz Mutter-Rottmayer, David W. Wyatt, Dale A. Ramsden

Publikováno v: The Journal of Cell Biology

The elevated CDK2 activity of oncogene-expressing cells induces DNA replication stress. Yang et al. show that the DNA repair protein RAD18 facilitates damage-tolerant DNA synthesis via the DNA polymerase κ in cells with aberrantly high CDK2 activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f7b55a03e69588ede3824d79d78949
https://doi.org/10.1083/jcb.201702006

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

Autor: Hessa S. Alsaif, Natalie J. Prescott, Dimitrios K. Papadopoulos, Martin R. Higgs, Sarah R. Wessel, Alex von Kriegsheim, David Cortez, Saleem Ahmed, Clare V. Logan, Andrea Leitch, Paula Carroll, B D Henderson, Olga Murina, Jumana Y. Al-Aama, Rachel M A Mottram, Janine Altmüller, Maha Alnemer, Peter Nürnberg, Audrey Vernet, Anastasia Zlatanou, Eissa Faqeih, John J. Reynolds, Louise S. Bicknell, Jennie E. Murray, Angela L. Duker, Ariella Amar, Sateesh Maddirevula, Alexander Brean, Luigina Spaccini, Mohammed Zain Seidahmed, Helen Cox, Mohammed Al Balwi, Carol Wise, Angela Peron, Kassiani Skouloudaki, Rachel C. Challis, Emma Hobson, Fowzan S. Alkuraya, Michael B. Bober, Abdulrahman Alswaid, Grant S. Stewart, Michael A. Simpson, E. Ferda Percin, Angela F. Brady, Hannah Bye, Raoul Heller, Gökhan Yigit, Žygimantė Tarnauskaitė, Grace Yoon, Christopher G. Mathew, Pavel Tomancak, Martin A M Reijns, Agaadir Almoisheer, Ranad Shaheen, Saeed Al Tala, Andrew P. Jackson, Alan J. Quigley, Yun Li, A. Malcolm R. Taylor, Rita Fischetto, Luciana Chessa, Seema Thakur

Publikováno v: Reynolds, J, Bicknell, L S, Carroll, P, Higgs, M R, Shaheen, R, Murray, J E, Papadopoulos, D K, Leitch, A, Murina, O, Tarnauskaite, Z, Wessel, S R, Zlatanou, A, Vernet, A, von Kriegsheim, A, Mottram, R M A, Logan, C V, Bye, H, Li, Y, Brean, A, Maddirevula, S, Challis, R C, Skouloudaki, K, Almoisheer, A, Alsaif, H S, Amar, A, Prescott, N J, Bober, M, Duker, A, Faqeih, E, Seidahmed, M Z, Tala, S A, Alswaid, A, Ahmed, S, Al-Aama, J Y, Altmuller, J, Al Balwi, M, Brady, A F, Chessa, L, Cox, H, Fischetto, R, Heller, R, Henderson, B D, Hobson, E, Nurnberg, P, Percin, E F, Peron, A, Spaccini, L, Quigley, A J, Thakur, S, Wise, C A, Yoon, G, Alnemer, M, Yigit, G, Taylor, A M R, Reijns, M A M, Simpson, M A, Cortez, D, Alkuraya, F S, Mathew, C G, Jackson, A P & Stewart, G S 2017, ' Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism ', Nature Genetics, vol. 49, no. 4, pp. 537–549 . https://doi.org/10.1038/ng.3790

To ensure efficient genome duplication, cells have evolved numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify downstream neighbor of SON (DONSON) as a novel fork protection factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46628f8b75da700e872119db9b156d27
https://europepmc.org/articles/PMC5450907/