Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects.

Autor: Moreira CVL; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil., Faria ALG; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil., Silva DPB; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil., Ghedini PC; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil., Martins JLR; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil; Graduate Program in Pharmaceutical Sciences, Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil., Keasling AW; Department of Chemistry, Andrew College, Cuthbert, GA 39840, USA., Zjawiony JK; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Pandey P; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Doerksen RJ; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Napolitano HB; Grupo de Química Teórica e Estrutural de Anápolis, Universidade Estadual de Goiás, 75001-970 Anápolis, GO, Brazil; Graduate Program in Pharmaceutical Sciences, Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil., da Rocha FF; Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil., Costa EA; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil., Fajemiroye JO; Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil; Graduate Program in Pharmaceutical Sciences, Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil. Electronic address: jamesfajemiroye@ufg.br.

Publikováno v: Fitoterapia [Fitoterapia] 2023 Jun; Vol. 167, pp. 105488. Date of Electronic Publication: 2023 Mar 27.

6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects.

Autor: Akins NS; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA., Mishra N; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA., Harris HM; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Dudhipala N; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Kim SJ; Natural Products Utilization Research Unit, United States Department of Agriculture, Agricultural Research Service, University, MS 38677, USA., Keasling AW; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA., Majumdar S; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Zjawiony JK; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Paris JJ; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Ashpole NM; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Le HV; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2022 Apr 05; Vol. 17 (7), pp. e202100684. Date of Electronic Publication: 2022 Feb 10.

Rotenoids and Other Specialized Metabolites from the Roots of Mirabilis multiflora : Opioid and Cannabinoid Receptor Radioligand Binding Affinities.

Autor: Sharma VK; Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States., Srivedavyasasri R; National Center for Natural Product Research (NCNPR), The University of Mississippi, University, Mississippi 38677, United States., Ali Z; National Center for Natural Product Research (NCNPR), The University of Mississippi, University, Mississippi 38677, United States., Zjawiony JK; Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States., Ross SA; Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.; National Center for Natural Product Research (NCNPR), The University of Mississippi, University, Mississippi 38677, United States., Ferreira D; Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States., Ashpole N; Department of BioMolecular Sciences, Division of Pharmacology, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States., Khan IA; Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.; National Center for Natural Product Research (NCNPR), The University of Mississippi, University, Mississippi 38677, United States.

Publikováno v: Journal of natural products [J Nat Prod] 2021 Apr 23; Vol. 84 (4), pp. 1392-1396. Date of Electronic Publication: 2021 Mar 18.

Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo

Autor: Aviello G, Borrelli F, GUIDA, Francesca, Romano B, Lewellyn K, De Chiaro M, Zjawiony JK, Izzo AA, Capasso R., LUONGO, Livio, MAIONE, Sabatino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::cda62b10315bd891709b4fdee6292c17
http://hdl.handle.net/11591/322523

Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors

Autor: Capasso R, Borrelli F, Cascio MG, Aviello G, Huben K, Zjawiony JK, Marini P, Romano B, Di Marzo V, Capasso F, Izzo AA.

Publikováno v: British journal of pharmacology 155 (2008): 681–689.
info:cnr-pdr/source/autori:Capasso R, Borrelli F, Cascio MG, Aviello G, Huben K, Zjawiony JK, Marini P, Romano B, Di Marzo V, Capasso F, Izzo AA./titolo:Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors/doi:/rivista:British journal of pharmacology/anno:2008/pagina_da:681/pagina_a:689/intervallo_pagine:681–689/volume:155

Salvinorin A, the active component of the hallucinogenic herb Salvia divinorum, inhibits intestinal motility through activation of kappa-opioid receptors (KORs). However, this compound may have target(s) other than the KORs in the inflamed gut. Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::12668712aca2cd7a7716790b559736fe
https://pubmed.ncbi.nlm.nih.gov/18622408