Circulating CD137 + T cells correlate with improved response to anti-PD1 immunotherapy in cancer patients

Autor: Zizzari, Ig, Di Filippo, A, Botticelli, A, Strigari, L, Pernazza, A, Rullo, E, Pignataro, Mg, Ugolini, A, Scirocchi, F, DI PIETRO, FRANCESCA ROMANA, Rossi, E, Gelibter, A, Schinzari, G, D'Amati, G, Rughetti, A, Marchetti, P, Nuti, M, Napoletano, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3686::e0cf0974754181b5d5cecf84aa90733f
http://hdl.handle.net/11573/1600648

Precision oncology targeting FGFRs: A systematic review on pre-clinical activity and clinical outcomes of pemigatinib.

Autor: Gnagni L; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy., Ruscito I; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy. Electronic address: ilary.ruscito@uniroma1.it., Zizzari IG; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy., Nuti M; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy., Napoletano C; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy. Electronic address: chiara.napoletano@uniroma1.it., Rughetti A; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome 324 -00161, Italy.

Publikováno v: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Oct; Vol. 202, pp. 104464. Date of Electronic Publication: 2024 Jul 31.

Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs.

Autor: Pace A; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Scirocchi F; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Napoletano C; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy. chiara.napoletano@uniroma1.it., Zizzari IG; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Po A; Department of Molecular Medicine, 'Sapienza' University of Rome, Rome, Italy., Megiorni F; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Asquino A; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Pontecorvi P; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Rahimi H; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Marchese C; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Ferretti E; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Nuti M; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy., Rughetti A; Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy.

Publikováno v: Journal of translational medicine [J Transl Med] 2023 Sep 15; Vol. 21 (1), pp. 626. Date of Electronic Publication: 2023 Sep 15.

Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach.

Autor: Botticelli A; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Cirillo A; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy. alessio.cirillo@uniroma1.it., Pomati G; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy., Cortesi E; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Rossi E; Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy., Schinzari G; Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.; Medical Oncology, Università Cattolica del Sacro Cuore, 00168, Rome, Italy., Tortora G; Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.; Medical Oncology, Università Cattolica del Sacro Cuore, 00168, Rome, Italy., Tomao S; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Fiscon G; Department of Computer, Control, and Management Engineering 'Antonio Ruberti', Sapienza University of Rome, Via Ariosto 25, 00185, Rome, Italy., Farina L; Department of Computer, Control, and Management Engineering 'Antonio Ruberti', Sapienza University of Rome, Via Ariosto 25, 00185, Rome, Italy., Scagnoli S; Department of Medical and Surgical Sciences and Translational Medicine, University of Rome 'Sapienza', 00185, Rome, Italy., Pisegna S; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Ciurluini F; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Chiavassa A; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Amirhassankhani S; Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Rd, Bishop's, London, SE1 7EH, UK., Ceccarelli F; Arthritis Center, Dipartimento Di Scienze Cliniche Internistiche, Anestesiologiche E Cardiovascolari, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy., Conti F; Arthritis Center, Dipartimento Di Scienze Cliniche Internistiche, Anestesiologiche E Cardiovascolari, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy., Di Filippo A; Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome 'Sapienza', 00161, Rome, Italy., Zizzari IG; Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome 'Sapienza', 00161, Rome, Italy., Napoletano C; Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome 'Sapienza', 00161, Rome, Italy., Rughetti A; Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome 'Sapienza', 00161, Rome, Italy., Nuti M; Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome 'Sapienza', 00161, Rome, Italy., Mezi S; Department of Radiological, Oncological and Pathological Science, Sapienza University of Rome, 00185, Rome, Italy., Marchetti P; Istituto Dermopatico Dell'Immacolata, 00167, Rome, Italy.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2023 Jul; Vol. 72 (7), pp. 2217-2231. Date of Electronic Publication: 2023 Mar 03.

Circulating CD137 ⁺ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients.

Autor: Cirillo A; Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, 'Sapienza' University of Rome, 00161 Rome, Italy.; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Zizzari IG; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Botticelli A; Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, 'Sapienza' University of Rome, 00161 Rome, Italy., Strigari L; Medical Physics Unit, 'Sant'Orsola-Malpighi' Hospital, 40138 Bologna, Italy., Rahimi H; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Scagnoli S; Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, 'Sapienza' University of Rome, 00161 Rome, Italy., Scirocchi F; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Pernazza A; Department of Radiology, Oncology and Pathology, 'Sapienza' University of Rome, 00161 Rome, Italy., Pace A; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Cerbelli B; Department of Radiology, Oncology and Pathology, 'Sapienza' University of Rome, 00161 Rome, Italy., d'Amati G; Department of Radiology, Oncology and Pathology, 'Sapienza' University of Rome, 00161 Rome, Italy., Marchetti P; Istituto Dermopatico dell'Immacolata (IDI-IRCCS), 00161 Rome, Italy., Nuti M; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Rughetti A; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Napoletano C; Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 12; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 12.