Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zizhi Tang"'
Autor:
Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M. Carr, Cong Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die. Combined with xenograft data the work identifies ENDOD1 as a potential cance
Externí odkaz:
https://doaj.org/article/6635eea4132e4bd4861d24a3f717f185
Autor:
Liang Song, Zizhi Tang, Changsheng Peng, Yueming Yang, Chang Guo, Danqing Wang, Liandi Guo, Jie Chen, Cong Liu
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic genomes. However, it re
Externí odkaz:
https://doaj.org/article/71ecc41e1c8647deb2c317321a07b5da
Autor:
Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with g
Externí odkaz:
https://doaj.org/article/90851237c1da49e3b8adae4d9ee702c7
Autor:
Ming Zeng, Laifeng Ren, Ken'Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, Cong Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination o
Externí odkaz:
https://doaj.org/article/6407999dc3614548856bdae2f9bb63f5
Autor:
Ming Zeng1, Zizhi Tang1, Laifeng Ren2, Haibin Wang3, Xiaojun Wang1, Wenyuan Zhu4, Xiaobing Mao5, Zeyang Li4, Xianming Mo5, Jun Chen6, Junhong Han5 hjunhong@scu.edu.cn, Daochun Kong4 kongdc@pku.edu.cn, Jianguo Ji4 jijg@pku.edu.cn, Carr, Antony M.7 carr.am@sussex.ac.uk, Cong Liu1 congliu@scu.edu.cn
Publikováno v:
Journal of Clinical Investigation. 12/1/2023, Vol. 133 Issue 23, p1-15. 15p.
Autor:
Ming Zeng, Zizhi Tang, Laifeng Ren, Haibin Wang, Xiaojun Wang, Wenyuan Zhu, Xiaobing Mao, Zeyang Li, Xianming Mo, Jun Chen, Junhong Han, Daochun Kong, Jianguo Ji, Antony M. Carr, Cong Liu
Many cancers harbour homologous recombination defects (HRD). The identification of PARP inhibitors as synthetic lethal with HRD has led to new therapeutic strategies for HRD cancers. Here we report a subtype of HRD that is caused by the perturbation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e3466ffbe69b8a22525e7d7b393a8f
https://doi.org/10.1101/2022.07.21.500952
https://doi.org/10.1101/2022.07.21.500952
Autor:
Tianyu Miao, Jie Chen, Changsheng Peng, Liandi Guo, Zizhi Tang, Wang Xiaojun, Shi Wang, Xiaobo Wang, Ming Zeng, Jichun Zhao, Cong Liu, Mingcai Zhao
Publikováno v:
Carcinogenesis. 42:640-649
Impairment of genome instability drives the development of cancer by disrupting anti-cancer barriers. Upon genotoxic insults, DNA damage responsive factors, notably ATM kinase, is crucial to protect genomic integrity while promoting cell death. Meanw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5229e84bedfdf0c5f4fb5ee51ce57488
https://doi.org/10.1093/carcin/bgab002
https://doi.org/10.1093/carcin/bgab002
Autor:
Chang Guo, Liandi Guo, Changsheng Peng, Yuegai Jia, Yueming Yang, Xiaojun Wang, Ming Zeng, Danqing Wang, Cong Liu, Mingcai Zhao, Jie Chen, Zizhi Tang
Publikováno v:
Experimental cell research. 417(2)
Malignancies including ovarian cancer (OvCa) are genetically unstable. Genomic integrity is maintained by tumor suppressor p53 and DNA damage response network, which crosstalk to each other via not well characterized mechanisms. In this work, we char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1981e68f5030c88ee6a03c829deca1d6
https://pubmed.ncbi.nlm.nih.gov/35644414
https://pubmed.ncbi.nlm.nih.gov/35644414
Autor:
Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M. Carr, Cong Liu
Publikováno v:
Nature communications. 13(1)
The atypical nuclease ENDOD1 functions with cGAS-STING in innate immunity. Here we identify a previously uncharacterized ENDOD1 function in DNA repair. ENDOD1 is enriched in the nucleus following H2O2 treatment and ENDOD1-/- cells show increased PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a64157955863669f71a7d67aa0e7f6
https://pubmed.ncbi.nlm.nih.gov/35606358
https://pubmed.ncbi.nlm.nih.gov/35606358
Autor:
Changsheng Peng, Chang Guo, Cong Liu, Yueming Yang, Danqing Wang, Liandi Guo, Jie Chen, Zizhi Tang, Liang Song
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Background Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic genomes. However, it remains elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2964b277eb4c72ee33029433107e9c6
https://pubmed.ncbi.nlm.nih.gov/33087072
https://pubmed.ncbi.nlm.nih.gov/33087072