Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Zizheng Dong"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100529- (2024)
FASN, the sole cytosolic enzyme responsible for de novo palmitate synthesis in mammalian cells, has been associated with poor prognosis in cancer and shown to cause drug and radiation resistance by upregulating DNA damage repair via suppression of p6
Externí odkaz:
https://doaj.org/article/94465603f95a412c911d175a55522b71
Autor:
Rima Tumia, Chao J. Wang, Tianhan Dong, Shijie Ma, Jenny Beebe, Juan Chen, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/520f2ea1254c451da068a62af4450741
Autor:
Rima Tumia, Chao J. Wang, Tianhan Dong, Shijie Ma, Jenny Beebe, Juan Chen, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Translation initiation in protein synthesis regulated by eukaryotic initiation factors (eIFs) is a crucial step in controlling gene expression. eIF3a has been shown to regulate protein synthesis and cellular response to treatments by anticancer agent
Externí odkaz:
https://doaj.org/article/2220767da4ce479ea9218ab217b228b2
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 776-785 (2013)
Fatty acid synthase (FASN) is a key enzyme in the synthesis of palmitate, the precursor of major nutritional, energetic, and signaling lipids. FASN expression is upregulated in many human cancers and appears to be important for cancer cell survival.
Externí odkaz:
https://doaj.org/article/a527282d20ef4775b3b42a96d5ddf115
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15276 (2010)
Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in multidrug resistance and protecting cancer stem cells. ABCG2-knockout had no apparent adverse effect on the development, biochemistry, and life of mice. Th
Externí odkaz:
https://doaj.org/article/54c23517ebde47058b45de50a97c5be7
Autor:
Hui Peng, Zizheng Dong, Jing Qi, Youyun Yang, Yang Liu, Zhaomin Li, Junkang Xu, Jian-Ting Zhang
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5676 (2009)
Multidrug resistance (MDR) is a major problem in successful treatment of cancers. Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in MDR and an important role in protecting cancer stem cells. Knockout of AB
Externí odkaz:
https://doaj.org/article/c1d009f7577b4a50beec68c1b6fcf79b
Autor:
Jenny Beebe, Sophia Josephraj, Chao J. Wang, Jacob Danielson, Qingbin Cui, Caoqinglong Huang, Lincoln Barlow, Ryan H. Zhang, Taolan Zhang, Harikrishna Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:13681-13691
Fatty acid synthase (FASN), a sole cytosolic enzyme responsible for de-novo lipid synthesis, is overexpressed in cancer but not in normal non-lipogenic tissues. FASN has been targeted, albeit no such inhibitor has been approved. Proton pump inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f985ce71de4643d861f34689f9c7d789
https://doi.org/10.1021/acs.jmedchem.2c00642
https://doi.org/10.1021/acs.jmedchem.2c00642
Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental Table S2. Sequences of primers for real time RT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a390e3ef512d7b7af690fa9b2926f1
https://doi.org/10.1158/1541-7786.22515373.v1
https://doi.org/10.1158/1541-7786.22515373.v1
Figure S1. 14-3-3σ contributes to IR resistance. Figure S2. 14-3-3σ contributes to IR resistance in H1299 cells. Figure S3. 14-3-3σ modulates IR-induced γ-H2AX in H1299 cells. Figure S4. 14-3-3σ promotes NHEJ but not HR repair of DSBs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baca7c689c622ceae1a5ed5a03e51e0f
https://doi.org/10.1158/1541-7786.22515376.v1
https://doi.org/10.1158/1541-7786.22515376.v1
Autor:
Jian-Ting Zhang, Chao-Nan Qian, Bin Tean Teh, David Petillo, Zhongfa Zhang, Sok Kean Khoo, Wenlin Huang, Ling Zhou, Jianguo Liu, Zizheng Dong, Ran-Yi Liu
PDF file, 24K, Table S1. SiRNA sequences; Table S2. Primer sequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1a53f2f268221b92577f55cd09e5a3
https://doi.org/10.1158/1535-7163.22497804
https://doi.org/10.1158/1535-7163.22497804