Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Zizhen Kang"'
Autor:
Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang
Publikováno v:
Cells, Vol 13, Iss 7, p 565 (2024)
Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as LRRK2 G2019S has emerged as the most prevalent variant associated with Park
Externí odkaz:
https://doaj.org/article/472c130cec2241ce8e3466d3b27577cb
Autor:
Quanri Zhang, Weiwei Liu, Han Wang, Hao Zhou, Katarzyna Bulek, Xing Chen, Cun-Jin Zhang, Junjie Zhao, Renliang Zhang, Caini Liu, Zizhen Kang, Robert A. Bermel, George Dubyak, Derek W. Abbott, Tsan Sam Xiao, Laura E. Nagy, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mincle is a pattern recognition receptor that senses danger signals in innate immune cells. Here authors show in an experimental autoimmune encephalomyelitis mouse model that tissue damage triggers Mincle signaling on inflammatory helper T cells, lea
Externí odkaz:
https://doaj.org/article/9dba327f0fa94c719a5ed5ddd82cfffe
Autor:
Weiwei Liu, Hao Zhou, Han Wang, Quanri Zhang, Renliang Zhang, Belinda Willard, Caini Liu, Zizhen Kang, Xiao Li, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
TLRs/IL-1R signaling play a role in high-fat diet induced adipose tissue dysfunction and obesity-associated metabolic syndrome. Here the authors report that adipocyte-specific deficiency of IL-1 Receptor-Associated Kinase M (IRAKM) ameliorates diet i
Externí odkaz:
https://doaj.org/article/86801061d8e24b74b82678d6a7b30bc5
Autor:
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS. We and
Externí odkaz:
https://doaj.org/article/b776c54cccf345be8e8c3228c536f749
Autor:
Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang, Ying Wang
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that autophagy-related gen
Externí odkaz:
https://doaj.org/article/0bc0dca2a6dd4beca235e573bdd9d71d
Autor:
Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to
Externí odkaz:
https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
Autor:
Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li
Publikováno v:
eLife, Vol 6 (2017)
Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 e
Externí odkaz:
https://doaj.org/article/5b84f1b2b69f41da8fc9474e0ca9c10d
Publikováno v:
Acta Crystallographica Section E, Vol 70, Iss 11, Pp o1199-o1199 (2014)
In the title compound, C11H11N3O3S·3H2O, the non-H atoms of the main molecule are approximately planar, with an r.m.s. deviation of 0.030 Å. There is a bifurcated intramolecular N—H...(O,S) hydrogen bond present forming S(6) and S(5) ring motifs.
Externí odkaz:
https://doaj.org/article/da5bebd0d61f4d4199cf73f0427f25b3
Autor:
Yun Liao, Jianxing Xiao, Xiao Li, Junjie Zhao, Caini Liu, Xiaoxia Li, William Miller-Little, Zizhen Kang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS. We and others h
Autor:
Theresa T. Pizarro, Xiaoxia Li, Shadi Swaidani, Nitish Rana, Junjie Zhao, William Miller-Little, Daniele Corridoni, Han Wang, Fangqiang Tang, Zizhen Kang, Yun Liao, Keith R. McCrae, Belinda Willard, Agne Antanaviciute, Alison Simmons, Fabio Cominelli, Xing Chen, George R. Dubyak, Katarzyna Bulek, Wen Qian
Publikováno v:
J Clin Invest
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1β. Here, we report a nonpyroptotic role of full-length GSDMD in guiding the release of IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9646118a51b6d46f4933f6246e116096
https://ruj.uj.edu.pl/xmlui/handle/item/267054
https://ruj.uj.edu.pl/xmlui/handle/item/267054