Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Ziying Yan"'
Autor:
Yinghua Tang, Mehrnoosh Ebadi, Junying Lei, Zehua Feng, Shahab Fakhari, Peipei Wu, Mark D. Smith, Maria P. Limberis, Roland Kolbeck, Katherine J. Excoffon, Ziying Yan, John F. Engelhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101244- (2024)
The dosing interval for effective recombinant adeno-associated virus (rAAV)-mediated gene therapy of cystic fibrosis lung disease remains unknown. Here, we assessed the durability of rAAV2.5T-fCFTRΔR-mediated transgene expression and neutralizing an
Externí odkaz:
https://doaj.org/article/27a6b1d9b32d4d5fbd5e3361073b18ed
Autor:
Yinghua Tang, Shahab Fakhari, Eric D. Huntemann, Zehua Feng, Peipei Wu, William Y. Feng, Junying Lei, Feng Yuan, Katherine J. Excoffon, Kai Wang, Maria P. Limberis, Roland Kolbeck, Ziying Yan, John F. Engelhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 70-80 (2023)
The efficacy of redosing the recombinant adeno-associated virus (rAAV) vector rAAV2.5T to ferret lung is limited by AAV neutralizing antibody (NAb) responses. While immunosuppression strategies have allowed for systemic rAAV repeat dosing, their util
Externí odkaz:
https://doaj.org/article/1cbaa351bc964c2ea2b39626805cbbeb
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Adeno-associated virus (AAV) belongs to the Dependoparvovirus genus of the Parvoviridae family. AAV replication relies on a helper virus, such as adenovirus (Ad). Co-infection of AAV and Ad induces a DNA damage response (DDR), although its f
Externí odkaz:
https://doaj.org/article/c4395243fd8549ceb40b6a15bdb9c53a
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010578 (2022)
Human bocavirus 1 (HBoV1), a member of the genus Bocaparvovirus of the family Parvoviridae, causes acute respiratory tract infections in young children. Well-differentiated pseudostratified human airway epithelium cultured at an air-liquid interface
Externí odkaz:
https://doaj.org/article/f157ccf24d4d4714be68593bf394a491
Autor:
Yinghua Tang, Ziying Yan, Shen Lin, Eric D. Huntemann, Zehua Feng, Soo-Yeun Park, Xingshen Sun, Eric Yuen, John F. Engelhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 186-200 (2020)
Readministration of recombinant adeno-associated virus (rAAV) may be necessary to treat cystic fibrosis (CF) lung disease using gene therapy. However, little is known about rAAV-mediated immune responses in the lung. Here, we demonstrate the suitabil
Externí odkaz:
https://doaj.org/article/d7466e4db45d4d0aaaee025e209b82d9
Autor:
Nan He, Xiaoming Liu, Amber R. Vegter, T. Idil A. Evans, Jaimie S. Gray, Junfeng Guo, Shashanna R. Moll, Lydia J. Guo, Meihui Luo, Ningxia Ma, Xingshen Sun, Bo Liang, Ziying Yan, Zehua Feng, Lisi Qi, Arnav S. Joshi, Weam Shahin, Yaling Yi, Katherine N. Gibson-Corley, Eric A. Hoffman, Kai Wang, Christian Mueller, John F. Engelhardt, Bradley H. Rosen
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease, but the field lacks a large-animal model that allows for longitudinal assessment of pulmonary function. We hypothesized
Externí odkaz:
https://doaj.org/article/628dc438f0564d82ab0c2f15a8972688
Autor:
Wei Zou, Min Xiong, Siyuan Hao, Elizabeth Yan Zhang, Nathalie Baumlin, Michael D. Kim, Matthias Salathe, Ziying Yan, Jianming Qiu
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Polarized human airway epithelia at an air-liquid interface (HAE-ALI) are an in vitro
Externí odkaz:
https://doaj.org/article/e895f8b367b04590b1a7aa0b8c7b00af
Autor:
Julia Fakhiri, Marc A. Schneider, Jens Puschhof, Megan Stanifer, Verena Schildgen, Stefan Holderbach, Yannik Voss, Jihad El Andari, Oliver Schildgen, Steeve Boulant, Michael Meister, Hans Clevers, Ziying Yan, Jianming Qiu, Dirk Grimm
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 202-222 (2019)
Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing attention is human bocavi
Externí odkaz:
https://doaj.org/article/7fbe1a7cee86481baac8bf16199ef869
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 40-51 (2018)
Human bocavirus 1 (HBoV1), an autonomous parvovirus, is a helper virus supporting replication of wild-type adeno-associated virus 2 (AAV2). In this study, we compared the helper functions from HBoV1 with those from adenovirus (Ad) for the production
Externí odkaz:
https://doaj.org/article/332ae2e9721046d7937f648a9c00174a
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates throughout human airways. The polarized human airway epithelium (HAE) cultured at an airway-liquid interface (HAE-ALI) is an in vitro model mimicking the in vivo human m
Externí odkaz:
https://doaj.org/article/9fa28d51b4454c60a53895cd42672c9d