Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Ziyang Cao"'
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 100949- (2024)
T-cell acute lymphoblastic leukemia (T-ALL), a heterogeneous hematological malignancy, is caused by the developmental arrest of normal T-cell progenitors. The development of targeted therapeutic regimens is impeded by poor knowledge of the stage-spec
Externí odkaz:
https://doaj.org/article/57c1b3b107c441b19a1f2f98c13f9770
Autor:
Bin Xu, Fanjun Zeng, Jialong Deng, Lintong Yao, Shengbo Liu, Hengliang Hou, Yucheng Huang, Hongyuan Zhu, Shaowei Wu, Qiaxuan Li, Weijie Zhan, Hongrui Qiu, Huili Wang, Yundong Li, Xianzhu Yang, Ziyang Cao, Yu Zhang, Haiyu Zhou
Publikováno v:
Bioactive Materials, Vol 27, Iss , Pp 337-347 (2023)
The abnormal activation of epidermal growth factor receptor (EGFR) drives the development of non-small cell lung cancer (NSCLC). The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked
Externí odkaz:
https://doaj.org/article/c56112cea3d24abca86d4c259a2b750b
Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1466-1477 (2022)
Acute myeloid leukemia (AML) is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments. The potent anti-cancer effects of bromodomain and extra-terminal domain (BET) inhibitors, targeting the key compo
Externí odkaz:
https://doaj.org/article/96fa857a76e5494db22824624576d7cf
Publikováno v:
Advanced Science, Vol 10, Iss 7, Pp n/a-n/a (2023)
Abstract The passive diffusion performance of nanocarriers results in inefficient drug transport across multiple biological barriers and consequently cancer therapy failure. Here, a magnetically driven amoeba‐like nanorobot (amNR) is presented for
Externí odkaz:
https://doaj.org/article/fe6705e3179c49a8b33ba937bffa29e0
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Delivering the correct concentration of drugs to the correct location is a challenge in cancer therapy. Here, the authors generate a drug loaded nanoparticle that enlarges following contact with the internal tumour cell environment, resulting in the
Externí odkaz:
https://doaj.org/article/0799be488a2f4d94b859a2b0e9e62140
Publikováno v:
Frontiers in Neuroinformatics, Vol 16 (2022)
BackgroundNeuroblastoma is the most common extracranial solid tumor of childhood, arising from the sympathetic nervous system. High-risk neuroblastoma (HRNB) remains a major therapeutic challenge with low survival rates despite the intensification of
Externí odkaz:
https://doaj.org/article/fbedbd388ebb4e7b8dfa5f6963876a45
Publikováno v:
Environmental Research Letters, Vol 18, Iss 10, p 104043 (2023)
The rare triple-dip 2020–2023 La Niña event has resulted in a series of extreme climate events across the globe. Here, we reveal the role of tropical Indo-Pacific oceanic interactions in driving the first triple-dip La Niña of the twenty-first ce
Externí odkaz:
https://doaj.org/article/d70be9127f28408ca35ee8037f75f9e2
Publikováno v:
International Journal of Infectious Diseases, Vol 99, Iss , Pp 77-83 (2020)
Background: Droplet digital PCR (ddPCR) is a technology that has higher sensitivity than real-time PCR for the identification of trace DNA. However, the use of ddPCR for the detection of Mycobacterium tuberculosis DNA in pathological samples has not
Externí odkaz:
https://doaj.org/article/1a635945eb5a4f2e82e163492ae1681e
Publikováno v:
Diagnostic Pathology, Vol 15, Iss 1, Pp 1-7 (2020)
Abstract Background Non-surgical cytological specimens are adequate not only for accurate histological subtyping but also for molecular profiling. A modified amplification refractory mutation system polymerase chain reaction (ARMS PCR), known as Supe
Externí odkaz:
https://doaj.org/article/4d15492ba72741a7b6da3321bfe47c1d
Enhancement of chemosensitivity by WEE1 inhibition in EGFR-TKIs resistant non-small cell lung cancer
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 117, Iss , Pp - (2019)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is the first-line treatment in non-resectable non-small lung cancer (NSCLC) with EGFR mutation. However, EGFR-TIKs resistance would inevitably develop within 9–14 months afte
Externí odkaz:
https://doaj.org/article/ff95eaa002bc44a8a62ed265dc4a8348