Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Zixu Mao"'
Autor:
Zhichun Chen, Wenming Li, Bo Meng, Chongchong Xu, Yiqi Huang, Guanglu Li, Zhexing Wen, Jun Liu, Zixu Mao
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110243- (2024)
Summary: Many clinical studies indicate a significant decrease of peripheral T cells in Parkinson’s disease (PD). There is currently no mechanistic explanation for this important observation. Here, we found that small extracellular vesicles (sEVs)
Externí odkaz:
https://doaj.org/article/c35365e7e66040f28c0ba8cab076e75b
Autor:
Anan Xu, Rong Li, Anbang Ren, Haifeng Jian, Zhong Huang, Qingxing Zeng, Baiyao Wang, Jieling Zheng, Xiaoyu Chen, Naiying Zheng, Ronghui Zheng, Yunhong Tian, Mengzhong Liu, Zixu Mao, Aimin Ji, Yawei Yuan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Microglia have been implicated in the pathogenesis of radiation-induced brain injury (RIBI), which severely influences the quality of life during long-term survival. Recently, irradiated microglia were speculated to present an agi
Externí odkaz:
https://doaj.org/article/a39b0c25e32d4c62a620ab2abb825c97
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-14 (2020)
Abstract Background Lysosomes digest extracellular material from the endocytic pathway and intracellular material from the autophagic pathway. This process is performed by the resident hydrolytic enzymes activated by the highly acidic pH within the l
Externí odkaz:
https://doaj.org/article/250b266128724197b8463c63cb10d15f
Publikováno v:
Neurobiology of Disease, Vol 122, Iss , Pp 41-48 (2019)
Protein homeostasis or proteostasis is critical for proper cellular function and survival. It relies on the balance between protein synthesis and degradation. Lysosomes play an important role in degrading and recycling intracellular components via au
Externí odkaz:
https://doaj.org/article/624a9ab0e6db4d62bf3742d4413a41ce
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylati
Externí odkaz:
https://doaj.org/article/fe92931b0c6143268e9973c526173436
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
Parkinson’s disease (PD), a complex neurodegenerative disorder, is pathologically characterized by the formation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial dysfunction is considered to
Externí odkaz:
https://doaj.org/article/140069ef1de2402585ae942e00550351
Autor:
Maria Čarna, Jan S. Novotny, Neda Dragišić, Hanuš Slavik, Kateřina Sheardova, Yonas E. Geda, Martin Vyhnalek, Jan Laczo, Jakub Hort, Zixu Mao, Robert A. Rissman, Marian Hajduch, Eric B. Dammer, Gorazd B. Stokin
Publikováno v:
Journal of Neurochemistry. 165:149-161
Publikováno v:
Electronics; Volume 12; Issue 11; Pages: 2492
Video-based flame detection (VFD) aims to recognize fire events by using image features. Flame segmentation is an essential task in VFD, providing suspected regions for feature analysis and object recognition. However, the lack of positive flame samp
Neuron-derived exosomes trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
Background Adaptive immunity plays an important role in Parkinson’s disease (PD). Multiple lines of evidence indicate a significant decrease in peripheral T cells in PD patients. Although this suppression impacts both overall immune and neuroimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10286220ce690d0ea544d3c457fed32b
https://doi.org/10.21203/rs.3.rs-2109216/v1
https://doi.org/10.21203/rs.3.rs-2109216/v1
Autor:
Huiping Liang, Zixu Mao, Quanquan Sun, Meiling Ai, Yawei Yuan, Muhammad Khan, Hongli Yang, Xiaoting Huang, Zhaoze Guo, Baiyao Wang, Jiang Zhang, Ronghui Zheng, Yunhong Tian
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 110:1234-1247
Purpose Polo-like kinase 1 (PLK1) is a protein kinase that is overexpressed in breast cancer and may represent an attractive target for breast cancer treatment. However, few studies have investigated the relationship between PLK1 and radiosensitivity